1-(tert-Butoxycarbonyl)-3,3-dimethyl-4-oxopiperidine

Product Name: 1-(tert-Butoxycarbonyl)-3,3-dimethyl-4-oxopiperidine
CAS No.: 324769-06-4
Chemical Name: 1-(tert-Butoxycarbonyl)-3,3-dimethyl-4-oxopiperidine
Synonyms: EOS-60807;1-boc-3,3-dimethyl4-piperidine;N-Boc-3,3-diMethyl-4-piperidone;1-Boc-3,3-diMethylpiperidin-4-one;1-BOC-3,3-dimethyl-4-oxopiperidine;N-BOC-3,3-dimethyl-4-oxopiperidine;3,3-Dimethylpiperidin-4-one, N-BOC protected;tert-butyl 3,3-diMethyl-4-oxopiperidine-1-carb;1-tert-Butoxycarbonyl-3,3-dimethyl-4-piperidone;3,3-Dimethylpiperidin-4-one, N-BOC protected 95%
CBNumber: CB91556363
Molecular Formula: C12H21NO3
Formula Weight: 227.3
MOL File: 324769-06-4.mol

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1-(tert-Butoxycarbonyl)-3,3-dimethyl-4-oxopiperidine Property

Boiling point:: 303℃
Density: 1.035
Flash point:: 137℃
storage temp.: 2-8°C
pka: -1.51±0.40(Predicted)
form: solid
color: off white
InChI: InChI=1S/C12H21NO3/c1-11(2,3)16-10(15)13-7-6-9(14)12(4,5)8-13/h6-8H2,1-5H3
InChIKey: MXCAGVCUIHYAGH-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCC(=O)C(C)(C)C1

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Safety

HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B694505
Product name: tert-Butyl3,3-Dimethyl-4-oxopiperidine-1-carboxylate
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 057230
Product name: tert-Butyl 3,3-dimethyl-4-oxopiperidine-1-carboxylate
Purity: 95%
Packaging: 1g
Price: $19
Updated: 2021/12/16

Matrix Scientific

Product number: 057230
Product name: tert-Butyl 3,3-dimethyl-4-oxopiperidine-1-carboxylate
Purity: 95%
Packaging: 5g
Price: $49
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB139333
Product name: tert-Butyl 3,3-dimethyl-4-oxopiperidine-1-carboxylate
Packaging: 2g
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: W5429
Product name: 1-(tert-Butoxycarbonyl)-3,3-dimethyl-4-oxopiperidine
Packaging: 1g
Price: $75
Updated: 2021/12/16

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1-(tert-Butoxycarbonyl)-3,3-dimethyl-4-oxopiperidine Chemical Properties,Usage,Production

Uses

1-(tert-Butoxycarbonyl)-3,3-dimethyl-4-oxopiperidine can be used as organic synthesis intermediates and pharmaceutical intermediates.

Synthesis

24424-99-5

173186-91-9

324769-06-4

General procedure for the synthesis of 1-BOC-3,3-dimethyl-4-oxopiperidine from di-tert-butyl dicarbonate and 3,3-dimethyl-1-phenylmethyl-piperidin-4-one: 10.14 g (46.66 mmol) of 1-benzyl-3,3-dimethyl-4-oxo-piperidine, 1.03 g of 10% palladium-carbon catalyst and 11.09 g (50.81 mmol) of di- di-tert-butyl carbonate were dissolved in 210 mL of methanol. The mixture was purged three times with nitrogen and then three times with hydrogen. Subsequently, the mixture was subjected to 50 psig hydrogen pressure and the reaction was shaken at room temperature for 16 hours. Upon completion of the reaction, the reaction mixture was filtered through a bed of diatomaceous earth and glass microfiber filter paper. The filtrate was concentrated under reduced pressure and the residue was purified by silica gel column chromatography using hexane containing 20% ethyl acetate as eluent. The elution grade containing the target product was collected and concentrated under reduced pressure to give 9.38 g (88.5% yield) of 1-(tert-butoxycarbonyl)-3,3-dimethyl-4-oxopiperidine.

References

[1] Patent: EP1204659, 2003, B1. Location in patent: Page/Page column 27
[2] Patent: EP1204660, 2004, B1. Location in patent: Page 18
[3] Patent: EP1204660, 2004, B1. Location in patent: Page 16-17
[4] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 10, p. 1627 - 1629
[5] Patent: US2002/169155, 2002, A1

1-(tert-Butoxycarbonyl)-3,3-dimethyl-4-oxopiperidine Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(tert-Butoxycarbonyl)-3,3-dimethyl-4-oxopiperidine Suppliers

China 130 India 1 United Kingdom 2 United States 10 Global 143

Wuxi InterpiPharm, Inc.

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Shangchem Co., Ltd.

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View Lastest Price from 1-(tert-Butoxycarbonyl)-3,3-dimethyl-4-oxopiperidine manufacturers

LY Global chemicals co.,ltd .

Product: 1-(TERT-BUTOXYCARBONYL)-3,3-DIMETHYL-4-OXOPIPERIDINE 324769-06-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98% Min
Supply Ability: 1000kg
Release date: 2023-03-18

Career Henan Chemical Co

Product: 1-(TERT-BUTOXYCARBONYL)-3,3-DIMETHYL-4-OXOPIPERIDINE 324769-06-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%
Supply Ability: 500KG
Release date: 2018-08-19

Career Henan Chemical Co

Product: 1-(TERT-BUTOXYCARBONYL)-3,3-DIMETHYL-4-OXOPIPERIDINE 324769-06-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%
Supply Ability: 500KG
Release date: 2018-08-19

324769-06-4, 1-(tert-Butoxycarbonyl)-3,3-dimethyl-4-oxopiperidineRelated Search:

tert-butyl 4-glycyl-1-piperazinecarboxylate(SALTDATA: HCl 0.95H2O) 1-BOC-4-AMINOMETHYL-PIPERIDINE HYDROCHLORIDE 1-BOC-3-METHYL-PIPERIDIN-4-ONE 1-(tert-Butoxycarbonyl)-3,3-dimethyl-4-oxopiperidine 1-TERT-BUTYL 3-ETHYL 3-METHYL-4-OXOPIPERIDINE-1,3-DICARBOXYLATE

1-(TERT-BUTOXYCARBONYL)-3,3-DIMETHYL-4-OXOPIPERIDINE

tert-butyl 3,3-dimethyl-4-oxopiperidine-1-carboxylate

1-Piperidinecarboxylic acid, 3,3-diMethyl-4-oxo-, 1,1-diMethylethyl ester

1,1-Dimethylethyl 3,3-dimethyl-4-oxo-1-piperidinecarboxylate

1-tert-Butoxycarbonyl-3,3-dimethyl-4-piperidone

1-tert-Butyloxycarbonyl-3,3-dimethyl-4-piperidone

3,3-Dimethyl-4-oxo-1-piperidinecarboxylic acid tert-butyl ester

tert-butyl 3,3-diMethyl-4-oxopiperidine-1-carb

1-Boc-3,3-diMethylpiperidin-4-one

N-Boc-3,3-diMethyl-4-piperidone

EOS-60807

3,3-Dimethylpiperidin-4-one, N-BOC protected 95%

1-boc-3,3-dimethyl4-piperidine

1-(TERT-BUTOXYCARBONYL)-3,3-DIMETHYL-4-OXOPIPERIDINE ISO 9001：2015 REACH

1-BOC-3,3-dimethyl-4-oxopiperidine

N-BOC-3,3-dimethyl-4-oxopiperidine

3,3-Dimethylpiperidin-4-one, N-BOC protected

324769-06-4