4-(bromomethyl)-1-chloro-2-methoxybenzene

Product Name: 4-(bromomethyl)-1-chloro-2-methoxybenzene
CAS No.: 103347-14-4
Chemical Name: 4-(bromomethyl)-1-chloro-2-methoxybenzene
Synonyms: 4-Chloro-3-Methoxybenzyl broMide;4-(bromomethyl)-1-chloro-2-methoxybenzene;Benzene, 4-(bromomethyl)-1-chloro-2-methoxy-
CBNumber: CB91559177
Molecular Formula: C8H8BrClO
Formula Weight: 235.51
MOL File: 103347-14-4.mol

More

Less

4-(bromomethyl)-1-chloro-2-methoxybenzene Property

Boiling point:: 115 °C(Press: 0.4 Torr)
Density: 1.520±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Dichloromethane, Ethyl Acetate
form: Oil
color: Pale Yellow

More

Less

Safety

HS Code: 2909309090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

More

Less

N-Bromosuccinimide Price

TRC

Product number: B688590
Product name: 4-(Bromomethyl)-1-chloro-2-methoxybenzene
Packaging: 500mg
Price: $340
Updated: 2021/12/16

Apolloscientific

Product number: OR310902
Product name: 4-Chloro-3-methoxybenzylbromide
Packaging: 250mg
Price: $288
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2707-D-02
Product name: 4-(Bromomethyl)-1-chloro-2-methoxybenzene
Packaging: 250mg
Price: $317
Updated: 2021/12/16

AK Scientific

Product number: Z3822
Product name: 4-(Bromomethyl)-1-chloro-2-methoxybenzene
Packaging: 1g
Price: $336
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0358573
Product name: 4-(BROMOMETHYL)-1-CHLORO-2-METHOXYBENZENE
Purity: 95.00%
Packaging: 5MG
Price: $497.11
Updated: 2021/12/16

More

Less

4-(bromomethyl)-1-chloro-2-methoxybenzene Chemical Properties,Usage,Production

Uses

4-(Bromomethyl)-1-chloro-2-methoxybenzene is an intermediate in the synthesis of 5-(3-((1H-1,2,4-Triazol-1-yl)methyl)-3-hydroxy-4,4-dimethylpentyl)-2-chlorophenol (T767575), which is a tebuconazole impurity. Tebuconazole (T013000) is an ergosterol biosynthesis inhibitor. Fungicide.

Synthesis

73909-16-7

103347-14-4

General procedure for the synthesis of 4-(bromomethyl)-1-chloro-2-methoxybenzene from 1-chloro-2-methoxy-4-methylbenzene: to a solution of 1-chloro-2-methoxy-4-methylbenzene (274 g, 1.75 mol) in dichloromethane (2.5 L) was added benzoyl peroxide (4.23 g, 0.02 mol) and N-bromosuccinimide (NBS. 321 g, 1.80 mol). The reaction mixture was heated to reflux for 1 h under mechanical stirring. After completion of the reaction, the reaction mixture was cooled, washed sequentially with 1N hydrochloric acid (2L), saturated sodium bicarbonate solution (2L) and brine (2L), dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to afford 4-(bromomethyl)-1-chloro-2-methoxybenzene as a pale yellow solid (412 g, quantitative yield).1H NMR (400 MHz, CDCl3): δ7.30- 7.34 (d, 1H), 6.95 (s, 1H), 6.91-6.93 (d, 1H), 4.45 (s, 2H), 3.92 (s, 3H).

References

[1] Patent: WO2011/71565, 2011, A1. Location in patent: Page/Page column 145-146
[2] Patent: WO2010/93845, 2010, A1. Location in patent: Page/Page column 136-137
[3] Patent: US6984657, 2006, B1
[4] Patent: US2007/244159, 2007, A1. Location in patent: Page/Page column 91
[5] Patent: US2011/98311, 2011, A1

4-(bromomethyl)-1-chloro-2-methoxybenzene Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

4-(bromomethyl)-1-chloro-2-methoxybenzene Suppliers

China 49 India 2 United Kingdom 1 United States 6 Global 58

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 16075
Advantage: 64

Nanjing Norris-Pharm Technology Co., Ltd

Tel: 18652989687
Fax: +86-25-52131256
Email: sales@norris-pharm.com
Country: China
ProdList: 8878
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Shanghai HuanChuan Industry Co.,Ltd.

Tel: 021-61478794
Fax: 021-61478794
Email: sales@hcshhai.com
Country: China
ProdList: 9793
Advantage: 50

Changzhou Anxuan Chemical, Co., Ltd.

Tel: 13912302692 13912302692;
Fax: 0519-88064678
Email: sales@anxuanchem.com
Country: China
ProdList: 4828
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Shanghai CR Corporation Limited

Tel: 13062833949; 4006653949 4006653949
Fax: QQ: 2136646215
Email: fred.wen@crcorporation.cn
Country: China
ProdList: 9756
Advantage: 58

Aikon International Limited

Tel: 025-66061636 18013972705
Fax: (3)02557626880
Email: qqyang@aikonchem.com
Country: China
ProdList: 15814
Advantage: 58

Henan Alfachem Co.,Ltd.

Tel: 0371-55051623 18137891487
Fax: QQ：2853979817
Email: 2853979817@qq.com
Country: China
ProdList: 9988
Advantage: 58

Yujinpharma(Tianjin) Technology Co.,Ltd.

Tel: 13370351217 kungfu1217@1
Fax: QQ1400885609
Email: kungfu1217@163.com
Country: China
ProdList: 2720
Advantage: 58

103347-14-4, 4-(bromomethyl)-1-chloro-2-methoxybenzeneRelated Search:

4-(bromomethyl)-1-chloro-2-methoxybenzene 4-CHLORO-3-(TRIFLUOROMETHOXY)BENZYL BROMIDE

4-(bromomethyl)-1-chloro-2-methoxybenzene

4-Chloro-3-Methoxybenzyl broMide

Benzene, 4-(bromomethyl)-1-chloro-2-methoxy-

103347-14-4