4-fluoro-1H-indole-7-carboxylic acid
Uses- Product Name
- 4-fluoro-1H-indole-7-carboxylic acid
- CAS No.
- 313337-34-7
- Chemical Name
- 4-fluoro-1H-indole-7-carboxylic acid
- Synonyms
- 7-Carboxy-4-fluoro-1H-indole;4-FLUORO-7-INDOLE CARBOXYLIC ACID;4-Fluoro indole-7-carboxylic aicd;4-fluoro-1H-indole-7-carboxylic acid;1H-Indole-7-carboxylic acid, 4-fluoro-
- CBNumber
- CB91559511
- Molecular Formula
- C9H6FNO2
- Formula Weight
- 179.15
- MOL File
- 313337-34-7.mol
4-fluoro-1H-indole-7-carboxylic acid Property
- Melting point:
- 227-228 °C
- Boiling point:
- 421.4±25.0 °C(Predicted)
- Density
- 1.510±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 4.88±0.10(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C9H6FNO2/c10-7-2-1-6(9(12)13)8-5(7)3-4-11-8/h1-4,11H,(H,12,13)
- InChIKey
- GDLCLHCOKQFBPI-UHFFFAOYSA-N
- SMILES
- N1C2=C(C(F)=CC=C2C(O)=O)C=C1
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- F593718
- Product name
- 4-fluoro-1H-indole-7-carboxylicacid
- Packaging
- 1mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 3361AB
- Product name
- 4-Fluoro-1H-indole-7-carboxylicacid
- Packaging
- 5g
- Price
- $1673
- Updated
- 2021/12/16
- Product number
- HCH0044187
- Product name
- 4-FLUORO-1H-INDOLE-7-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 2G
- Price
- $2829.75
- Updated
- 2021/12/16
- Product number
- HCH0044187
- Product name
- 4-FLUORO-1H-INDOLE-7-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $4365.9
- Updated
- 2021/12/16
- Product number
- P2800
- Product name
- 4-fluoro-1H-Indole-7-carboxylicacid
- Purity
- 97.00%
- Packaging
- 25G
- Price
- $4010
- Updated
- 2021/12/16
4-fluoro-1H-indole-7-carboxylic acid Chemical Properties,Usage,Production
Uses
4-Fluoro-7-carboxyindole is mainly used in organic synthesis and chemical and pharmaceutical research and development.
Synthesis
313337-33-6
313337-34-7
Step B: Potassium hydroxide (13.04 g, 0.232 mol) was dissolved in a 14% water/ethanol mixture (50 ml) and 4-fluoro-1H-indole-7-carbonitrile (900 mg, 5.60 mmol) was added. The reaction mixture was refluxed for 12 h followed by slow cooling to room temperature and concentrated under vacuum to about 30 ml. The residue was acidified to pH 2 with an aqueous hydrochloric acid solution of about 5.5 N. The precipitate was collected by filtration, washed with excess water and dried under high vacuum to give 4-fluoro-7-carboxyindole as a white solid (100% conversion). The resulting product can be used in subsequent reactions without further purification.
References
[1] Patent: US6469006, 2002, B1
[2] Patent: US2004/6090, 2004, A1. Location in patent: Page/Page column 33
[3] Patent: WO2004/11425, 2004, A2. Location in patent: Page 73
[4] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 1, p. 198 - 202
4-fluoro-1H-indole-7-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
4-fluoro-1H-indole-7-carboxylic acid Suppliers
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