5-Bromo-6-trifluoromethyl-pyridin-2-ylamine
Uses- Product Name
- 5-Bromo-6-trifluoromethyl-pyridin-2-ylamine
- CAS No.
- 882500-21-2
- Chemical Name
- 5-Bromo-6-trifluoromethyl-pyridin-2-ylamine
- Synonyms
- 101906;5-Bromo-6-(trifluoromethyl)pyridine;5-bromo-6-(trifluoromethyl)pyridin-2-amine;2-Pyridinamine,5-bromo-6-(trifluoromethyl)-;2-Amino-5-bromo-6-(trifluoromethyl)pyridine;6-Amino-3-bromo-2-(trifluoromethyl)pyridine;5-Bromo-6-trifluoromethyl-pyridin-2-ylamine;5-Bromo-6-trifluoromethyl-pyridin-2-ylamine ISO 9001：2015 REACH
- CBNumber
- CB91559940
- Molecular Formula
- C6H4BrF3N2
- Formula Weight
- 241.01
- MOL File
- 882500-21-2.mol
5-Bromo-6-trifluoromethyl-pyridin-2-ylamine Property
- Boiling point:
- 218℃
- Density
- 1.790
- Flash point:
- 86℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 1.04±0.10(Predicted)
- Appearance
- Off-white to yellow Solid
- InChI
- InChI=1S/C6H4BrF3N2/c7-3-1-2-4(11)12-5(3)6(8,9)10/h1-2H,(H2,11,12)
- InChIKey
- DNDAEASRGBLZCN-UHFFFAOYSA-N
- SMILES
- C1(N)=NC(C(F)(F)F)=C(Br)C=C1
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A595165
- Product name
- 6-Amino-3-Bromo-2-trifluoromethylpyridine
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- A595165
- Product name
- 6-Amino-3-Bromo-2-trifluoromethylpyridine
- Packaging
- 250mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- PC201346
- Product name
- 5-Bromo-6-trifluoromethylpyridin-2-ylamine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $96
- Updated
- 2021/12/16
- Product number
- 3H30-B-0C
- Product name
- 5-Bromo-6-trifluoromethylpyridin-2-ylamine
- Purity
- 95.0%
- Packaging
- 1g
- Price
- $106
- Updated
- 2021/12/16
- Product number
- W9045
- Product name
- 5-Bromo-6-trifluoromethylpyridin-2-ylamine
- Packaging
- 1g
- Price
- $134
- Updated
- 2021/12/16
5-Bromo-6-trifluoromethyl-pyridin-2-ylamine Chemical Properties,Usage,Production
Uses
5-Bromo-6-trifluoromethyl-2-aminopyridine is a pyridine derivative that can be used as a pharmaceutical intermediate.
Synthesis
34486-24-3
882500-21-2
The general procedure for the synthesis of 5-bromo-6-(trifluoromethyl)-2-aminopyridine from 2-amino-6-(trifluoromethyl)pyridine was as follows: to a solution of 6-(trifluoromethyl)pyridin-2-amine (600 mg, 3.7 mmol) in methanol (10 mL) was added N-bromosuccinimide (NBS, 659 mg, 3.7 mmol) in batches at 0 °C. The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure and the residue was purified by column chromatography (eluent: petroleum ether/ethyl acetate = 4:1) to afford 5-bromo-6-trifluoromethyl-2-aminopyridine (650 mg, 73.1% yield) as a white solid.The LC-MS analysis showed a retention time of 1.33 min and a molecular ion peak (MH+) of 241.
References
[1] Patent: WO2016/44792, 2016, A1. Location in patent: Page/Page column 173
[2] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 1, p. 527 - 531
[3] Patent: WO2017/1926, 2017, A2. Location in patent: Paragraph 00139
[4] Patent: CN105541792, 2016, A. Location in patent: Paragraph 0242; 0243; 0244
5-Bromo-6-trifluoromethyl-pyridin-2-ylamine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Bromo-6-trifluoromethyl-pyridin-2-ylamine manufacturers
- Product
- 5-Bromo-6-trifluoromethyl-pyridin-2-ylamine 882500-21-2
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-25
- Product
- 5-Bromo-6-trifluoromethyl-pyridin-2-ylamine 882500-21-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 5-Bromo-6-trifluoromethyl-pyridin-2-ylamine 882500-21-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09