8-methylquinazoline-2,4(1H,3H)-dione
- Product Name
- 8-methylquinazoline-2,4(1H,3H)-dione
- CAS No.
- 67449-23-4
- Chemical Name
- 8-methylquinazoline-2,4(1H,3H)-dione
- Synonyms
- 8-methylquinazoline-2,4-diol;2,4-Dihydroxy-8-methylquinazoline;8-methyl-1H-quinazoline-2,4-dione;8-methylquinazoline-2,4(1H,3H)-dione;2,4(1H,3H)-Quinazolinedione, 8-methyl-;8-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline;8-Methyl-1,2,3,4-tetrahydroquinazoline-2,4-dione
- CBNumber
- CB91560405
- Molecular Formula
- C9H8N2O2
- Formula Weight
- 176.17
- MOL File
- 67449-23-4.mol
8-methylquinazoline-2,4(1H,3H)-dione Property
- Melting point:
- 283 °C
- Density
- 1.280±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 11.13±0.20(Predicted)
- Appearance
- Off-white to light yellow Solid
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-W001030
- Product name
- 8-methylquinazoline-2,4-diol
- Packaging
- 1g
- Price
- $89
- Updated
- 2021/12/16
- Product number
- 4H48-1-MW
- Product name
- 8-Methyl-1,2,3,4-tetrahydroquinazoline-2,4-dione
- Packaging
- 1g
- Price
- $199
- Updated
- 2021/12/16
- Product number
- CS-W001030
- Product name
- 8-methylquinazoline-2,4-diol
- Packaging
- 5g
- Price
- $277
- Updated
- 2021/12/16
- Product number
- CS-W001030
- Product name
- 8-methylquinazoline-2,4-diol
- Packaging
- 10g
- Price
- $472
- Updated
- 2021/12/16
- Product number
- CHM0101832
- Product name
- 8-METHYLQUINAZOLINE-2,4(1H,3H)-DIONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.49
- Updated
- 2021/12/16
8-methylquinazoline-2,4(1H,3H)-dione Chemical Properties,Usage,Production
Synthesis
4389-45-1
57-13-6
67449-23-4
GENERAL METHOD: 2-Amino-3-methylbenzoic acid (5.0 g, 33.1 mmol) was mixed with urea (20 g) and the reaction was stirred at 160°C for 6 hours. Upon completion of the reaction, the reaction mixture was cooled to 100 °C and an equal volume of water was slowly added with continuous stirring for 5 min. Subsequently, the precipitate formed was collected by filtration and washed with cold water to obtain a solid filter cake. This filter cake was suspended in 0.5 N NaOH aqueous solution, heated to boiling and held for 5 minutes, then cooled to room temperature. The pH of the suspension was adjusted to 2 with concentrated hydrochloric acid and the quinazoline dione product was collected by filtration. The product was washed with a mixture of water: methanol (1:1) and dried under vacuum to give 4.50 g (25.5 mmol, 77% yield) of 2,4-dihydroxy-8-methylquinazoline solid. The 1H-NMR (CDCl3) data of the product were as follows: δ (ppm) 7.78-7.74 (m, 1H), 7.49-7.46 (m, 1H), 7.11-7.05 (m, 1H), 2.31 (s, 3H).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 1, p. 461 - 467
[2] Synthesis (Germany), 2016, vol. 48, # 8, p. 1226 - 1234
[3] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 3, p. 254 - 259
[4] Journal of Medicinal Chemistry, 2014, vol. 57, # 12, p. 5141 - 5156
[5] Patent: US2016/90374, 2016, A1. Location in patent: Paragraph 0170; 0171
8-methylquinazoline-2,4(1H,3H)-dione Preparation Products And Raw materials
Raw materials
Preparation Products
8-methylquinazoline-2,4(1H,3H)-dione Suppliers
- Tel
- 18030648795
- Fax
- 028-61777050
- sales@cdforestchem.com
- Country
- China
- ProdList
- 2000
- Advantage
- 58
- Tel
- 150-2103-5486 18017383231
- Fax
- qq：2817624287
- 983544897@qq.com
- Country
- China
- ProdList
- 9342
- Advantage
- 55
- Tel
- 13120367189
- Fax
- 021-50315529
- mychess007@163.com
- Country
- China
- ProdList
- 1994
- Advantage
- 55
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 13356901049
- Fax
- QQ：1025383091
- 3119594100@qq.com
- Country
- China
- ProdList
- 7964
- Advantage
- 55
- Tel
- 021-021-021-31663258 13795219287
- Fax
- 021-31663258
- donghuanwen@126.com
- Country
- China
- ProdList
- 8816
- Advantage
- 58
- Tel
- 13933818572
- Fax
- 0311-82870388
- 1519554262@qq.com
- Country
- China
- ProdList
- 1785
- Advantage
- 58
- Tel
- 022-59987777 13552403979
- jia_guoqiang@wuxiapptec.com
- Country
- China
- ProdList
- 22345
- Advantage
- 58
- Tel
- +86-（0）57185586718; +8613336195806
- Fax
- +86-571-85864795
- sales@capot.com
- Country
- China
- ProdList
- 29735
- Advantage
- 60
- Tel
- 025-66113011 13155353615
- Fax
- (7)02557626880
- qzhang@aikonchem.com
- Country
- China
- ProdList
- 15394
- Advantage
- 58
- Tel
- 400-668-9898
- Fax
- 010-51582189
- service@3achem.com
- Country
- China
- ProdList
- 20557
- Advantage
- 58
- Tel
- 4009004166/18616739031 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52687
- Advantage
- 58
- Tel
- 021-50430803 18016036736
- Fax
- qq：1278656443
- lyh_antaeus@163.com
- Country
- China
- ProdList
- 760
- Advantage
- 58
- Tel
- meitaochem@126.com
- meitaochem@126.com
- Country
- China
- ProdList
- 19103
- Advantage
- 58
- Tel
- +86-0371-86658258 +8613203830695
- Fax
- 0371-86658258
- laboratory@coreychem.com
- Country
- China
- ProdList
- 30229
- Advantage
- 58
- Tel
- 15021845385
- 765325601@qq.com
- Country
- China
- ProdList
- 3609
- Advantage
- 58
- Tel
- 微信 17321281695 18019252918
- Fax
- qq:1454668768
- 1454668768@qq.com
- Country
- China
- ProdList
- 14873
- Advantage
- 58
- Tel
- 021-50795510 4000665055
- sales@accelachem.com
- Country
- China
- ProdList
- 10467
- Advantage
- 58
- Tel
- 021-58461859 15821823057
- service@aiviche.com
- Country
- China
- ProdList
- 49312
- Advantage
- 58
- Tel
- 400-8210725 4008210725
- malulu@leyan.com
- Country
- China
- ProdList
- 40000
- Advantage
- 58
- Tel
- 400-6005915
- sales@picasso-e.com
- Country
- China
- ProdList
- 39653
- Advantage
- 58
- Tel
- 025-87138562 18951783565
- sales@popebiotech.com
- Country
- China
- ProdList
- 1112
- Advantage
- 58
- Tel
- 1173954148q
- meishipharma@126.com
- Country
- China
- ProdList
- 20033
- Advantage
- 58
- Tel
- 13356901049
- mark@sklnchem.cn
- Country
- China
- ProdList
- 7997
- Advantage
- 58
- Tel
- 181-3307-5798 18017383231
- 983544897@qq.com
- Country
- China
- ProdList
- 921
- Advantage
- 58
- Tel
- 15021035486 18081542813
- 1804873256@qq.com
- Country
- China
- ProdList
- 6684
- Advantage
- 58
- Tel
- 010-50973130 17801761073
- Gsiyu@solarbio.com
- Country
- China
- ProdList
- 50464
- Advantage
- 58
- Tel
- 021-57520305 13795461237
- zhuruyan@jskchem.com
- Country
- China
- ProdList
- 49234
- Advantage
- 58
- Tel
- 021-54306202 18917919676
- info@hanhongsci.com
- Country
- China
- ProdList
- 29995
- Advantage
- 58
- Tel
- 051915240519135 13961152745
- yudiguimo@126.COM
- Country
- China
- ProdList
- 10000
- Advantage
- 58
- Tel
- 18321033991
- marketing@pharmalego.com
- Country
- China
- ProdList
- 3582
- Advantage
- 58
- Tel
- 15901279280
- 4574688522@qq.com
- Country
- China
- ProdList
- 480
- Advantage
- 58
- Tel
- 21-20338288
- ordercn@merckgroup.com
- Country
- China
- ProdList
- 6394
- Advantage
- 58
- Tel
- 13012344321
- 3995296515@qq.com
- Country
- China
- ProdList
- 8448
- Advantage
- 58
- Tel
- 2351098207
- 2351098207@qq.com
- Country
- China
- ProdList
- 924
- Advantage
- 58
- Tel
- +86-88938639 +86-17705817739
- info@dycnchem.com
- Country
- China
- ProdList
- 53899
- Advantage
- 58
- Tel
- +86-2552131256 +86-18251840740
- sales@bicbiotech.com
- Country
- China
- ProdList
- 5994
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@hzdxbio.com
- Country
- CHINA
- ProdList
- 251
- Advantage
- 58