methyl 2-fluoro-4-methylbenzoate

Product Name: methyl 2-fluoro-4-methylbenzoate
CAS No.: 74733-29-2
Chemical Name: methyl 2-fluoro-4-methylbenzoate
Synonyms: methyl 2-fluoro-4-methylbenzoate;2-Fluoro-4-Methyl-benzoic acid Methyl ester;methyl 2-fluoro-4-methylbenzoate - [AC78605];Benzoic acid, 2-fluoro-4-methyl-, methyl ester
CBNumber: CB91561260
Molecular Formula: C9H9FO2
Formula Weight: 168.16
MOL File: 74733-29-2.mol

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methyl 2-fluoro-4-methylbenzoate Property

Boiling point:: 226.8±28.0 °C(Predicted)
Density: 1.137±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
Appearance: White to off-white Solid

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Safety

HS Code: 2916399090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M321645
Product name: Methyl2-Fluoro-4-methylbenzoate
Packaging: 250mg
Price: $75
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0044528
Product name: METHYL 2-FLUORO-4-METHYLBENZOATE
Purity: 95.00%
Packaging: 5MG
Price: $503.64
Updated: 2021/12/16

Apolloscientific

Product number: PC909749
Product name: Methyl2-fluoro-4-methylbenzoate
Purity: 95%
Packaging: 25g
Price: $833
Updated: 2021/12/16

Alichem

Product number: 74733292
Product name: Methyl2-fluoro-4-methylbenzoate
Packaging: 500mg
Price: $863.9
Updated: 2021/12/16

Alichem

Product number: 74733292
Product name: Methyl2-fluoro-4-methylbenzoate
Packaging: 1g
Price: $1445.3
Updated: 2021/12/16

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methyl 2-fluoro-4-methylbenzoate Chemical Properties,Usage,Production

Synthesis

67-56-1

7697-23-6

74733-29-2

(f) Methyl 2-fluoro-4-methylbenzoate (5): Method A: To a mixture of 2-fluoro-4-methylbenzoic acid (2.0 g, 13.0 mmol) and K2CO3 (3.6 g, 26.0 mmol) in acetonitrile (15 mL) was added CH3I (1.6 mL, 25.6 mmol) dropwise with stirring. The reaction mixture was heated to reflux overnight and the solvent was removed by distillation under reduced pressure. The residue was dissolved with EtOAc, washed sequentially with water and saturated saline, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with hexane/EtOAc (6:1) as eluent to give a white solid 5 (1.73 g, 79% yield) with melting point 51-53 °C.1H NMR (CDCl3) δ: 7.83 (t, J=8.0 Hz, 1H), 7.00 (dd, J=8.0,1.0 Hz, 1H), 6.95 (d, J= 12.0 Hz, 1H), 3.91 (s, 3H), 2.39 (s, 3H). Method B: Concentrated sulfuric acid (5 mL) was added dropwise to a solution of 2-fluoro-4-methylbenzoic acid (7.0 g, 45.4 mmol) in MeOH (100 mL) under stirring. The reaction mixture was heated to reflux overnight and then the solvent was removed by distillation under reduced pressure. The residue was dissolved with EtOAc, washed with saturated aqueous NaHCO3 and saturated saline in turn, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with hexane/EtOAc (6:1) as eluent to give white solid 5 (6.88 g, 90% yield). The analytical data were the same as that of Method A.

References

[1] Patent: WO2010/116270, 2010, A1. Location in patent: Page/Page column 55
[2] Organic Process Research and Development, 2011, vol. 15, # 3, p. 565 - 569
[3] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 7, p. 1742 - 1747
[4] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 24, # 7, p. 1742 - 1747
[5] Patent: EP1449844, 2004, A1. Location in patent: Page 22

methyl 2-fluoro-4-methylbenzoate Preparation Products And Raw materials

Raw materials

Preparation Products

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methyl 2-fluoro-4-methylbenzoate Suppliers

China 60 India 1 United States 3 Global 64

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74733-29-2, methyl 2-fluoro-4-methylbenzoateRelated Search:

methyl 2-fluoro-4-methylbenzoate

2-Fluoro-4-Methyl-benzoic acid Methyl ester

Benzoic acid, 2-fluoro-4-methyl-, methyl ester

methyl 2-fluoro-4-methylbenzoate - [AC78605]

74733-29-2