ChemicalBook > CAS DataBase List > BRL 44408 MALEATE

BRL 44408 MALEATE

Product Name
BRL 44408 MALEATE
CAS No.
118343-19-4
Chemical Name
BRL 44408 MALEATE
Synonyms
BRL 44408;BRL 44408 MALEATE;BRL 44408 maleate salt;2-[2H-(1-METHYL-1,3-DIHYDROISOINDOLE)METHYL]-4,5-DIHYDROIMIDAZOLE MALEATE;2-[(4,5-Dihydro-1H-imidazol-2-yl)methyl]-2,3-dihydro-1-methyl-1H-isoindole;2-[[(1-Methyl-1,3-dihydro-2H-isoindol)-2-yl]methyl]-4,5-dihydro-1H-imidazole;1H-Isoindole, 2-[(4,5-dihydro-1H-imidazol-2-yl)methyl]-2,3-dihydro-1-methyl-;2-[2H-(1-Methyl-1,3-dihydroisoindole)methyl]-4,5-dihydroimidazole maleate salt;2-[(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)METHYL]-2,3-DIHYDRO-1-METHYL-1H-ISOINDOLE MALEATE;2-((4,5-dihydro-1H-imidazol-2-yl)methyl)-2,3-dihydro-1-methyl-1H-isoindole BRL 44408
CBNumber
CB9159570
Molecular Formula
C13H17N3
Formula Weight
215.29
MOL File
118343-19-4.mol
More
Less

BRL 44408 MALEATE Property

Boiling point:
365.8±30.0 °C(Predicted)
Density 
1.22±0.1 g/cm3(Predicted)
storage temp. 
Desiccate at -20°C
solubility 
H2O: ~26 mg/mL, soluble
form 
solid
pka
10.29±0.40(Predicted)
color 
off-white
Water Solubility 
H2O: soluble 15mg/mL, clear
InChI
1S/C13H17N3.C4H4O4/c1-10-12-5-3-2-4-11(12)8-16(10)9-13-14-6-7-15-13;5-3(6)1-2-4(7)8/h2-5,10H,6-9H2,1H3,(H,14,15);1-2H,(H,5,6)(H,7,8)/b;2-1-
InChIKey
DDIQGSUEJOOQQQ-BTJKTKAUSA-N
SMILES
OC(=O)\C=C/C(O)=O.CC1N(CC2=NCCN2)Cc3ccccc13
More
Less

Safety

WGK Germany 
3
Storage Class
11 - Combustible Solids
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B4559
Product name
BRL 44408 maleate salt
Purity
≥98% (HPLC)
Packaging
10mg
Price
$182.4
Updated
2025/07/31
Sigma-Aldrich
Product number
B4559
Product name
BRL 44408 maleate salt
Purity
≥98% (HPLC)
Packaging
50mg
Price
$811
Updated
2025/07/31
Tocris
Product number
1133
Product name
BRL44408maleate
Purity
≥98%(HPLC)
Packaging
10
Price
$173
Updated
2021/12/16
Tocris
Product number
1133
Product name
BRL44408maleate
Purity
≥98%(HPLC)
Packaging
50
Price
$724
Updated
2021/12/16
TRC
Product number
B677680
Product name
BRL44408
Packaging
100mg
Price
$1175
Updated
2021/12/16
More
Less

BRL 44408 MALEATE Chemical Properties,Usage,Production

Uses

Selective a2A-adrenoceptor antagonist . Increases hippocampal noradrenaline release following systemic administration

Uses

Selective α2A-adrenoceptor antagonist . Increases hippocampal noradrenaline release following systemic administration.

Uses

BRL 44408 Maleate was used to study for norepinephrine reuptake modulators for preventing and treating vasomotor symptoms.

Biological Activity

Selective α 2A -adrenoceptor antagonist (K i = 1.7 nM and 144.5 nM at α 2A and α 2B -adrenergic receptors respectively). Increases hippocampal noradrenalin release following systemic administration. Also available as part of the α 2 -Adrenoceptor Tocriset™ .

Biochem/physiol Actions

BRL 44408 maleate is a selective α2A-adrenoceptor antagonist.

References

[1]. meana jj, callado lf, pazos a, et al. the subtype-selective alpha 2-adrenoceptor antagonists brl 44408 and arc 239 also recognize 5-ht1a receptors in the rat brain. eur j pharmacol, 1996, 312(3): 385-388.
[2]. owesson ca, seif i, mclaughlin dp, et al. different alpha(2) adrenoceptor subtypes control noradrenaline release and cell firing in the locus coeruleus of wildtype and monoamine oxidase-a knockout mice. eur j neurosci, 2003, 18(1): 34-42.
[3]. dwyer jm, platt bj, rizzo sj, et al. preclinical characterization of brl 44408: antidepressant- and analgesic-like activity through selective alpha2a-adrenoceptor antagonism. int j neuropsychopharmacol, 2010, 13(9): 1193-1205.

BRL 44408 MALEATE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

BRL 44408 MALEATE Suppliers

Canada 1 China 42 Europe 1 Germany 2 India 2 Switzerland 1 United Kingdom 2 United States 7 Global 58
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
Advantage
69
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
Advantage
65
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25716
Advantage
65
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57422
Advantage
58

118343-19-4, BRL 44408 MALEATERelated Search:

BRL 44408 MALEATE

  • 2-[(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)METHYL]-2,3-DIHYDRO-1-METHYL-1H-ISOINDOLE MALEATE
  • 2-[2H-(1-METHYL-1,3-DIHYDROISOINDOLE)METHYL]-4,5-DIHYDROIMIDAZOLE MALEATE
  • BRL 44408 MALEATE
  • 2-[[(1-Methyl-1,3-dihydro-2H-isoindol)-2-yl]methyl]-4,5-dihydro-1H-imidazole
  • Alendronate sodium trihydrate,4-amino-1-hydroxy-1-phosphonobutyl phosphonic acid, monosodium, MK-217
  • 2-[(4,5-Dihydro-1H-imidazol-2-yl)methyl]-2,3-dihydro-1-methyl-1H-isoindole
  • BRL 44408
  • 2-[2H-(1-Methyl-1,3-dihydroisoindole)methyl]-4,5-dihydroimidazole maleate salt
  • BRL 44408 maleate salt
  • 2-((4,5-dihydro-1H-imidazol-2-yl)methyl)-2,3-dihydro-1-methyl-1H-isoindole BRL 44408
  • 1H-Isoindole, 2-[(4,5-dihydro-1H-imidazol-2-yl)methyl]-2,3-dihydro-1-methyl-
  • 118343-19-4
  • C17H21N3OD4
  • C13H17N3ClH
  • C13H17N3C4H4O4
  • Chromatography
  • Forensic and Veterinary Standards
  • Drug Standards
  • Analytical Chromatography Product Catalog
  • Analytical Standards
  • Heterocyclic Compounds
  • Bases & Related Reagents
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Nucleotides
  • Pharmaceuticals
  • Adrenoceptor