BRL 44408 MALEATE

Product Name: BRL 44408 MALEATE
CAS No.: 118343-19-4
Chemical Name: BRL 44408 MALEATE
Synonyms: BRL 44408;BRL 44408 MALEATE;BRL 44408 maleate salt;2-[2H-(1-METHYL-1,3-DIHYDROISOINDOLE)METHYL]-4,5-DIHYDROIMIDAZOLE MALEATE;2-[(4,5-Dihydro-1H-imidazol-2-yl)methyl]-2,3-dihydro-1-methyl-1H-isoindole;2-[[(1-Methyl-1,3-dihydro-2H-isoindol)-2-yl]methyl]-4,5-dihydro-1H-imidazole;1H-Isoindole, 2-[(4,5-dihydro-1H-imidazol-2-yl)methyl]-2,3-dihydro-1-methyl-;2-[2H-(1-Methyl-1,3-dihydroisoindole)methyl]-4,5-dihydroimidazole maleate salt;2-[(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)METHYL]-2,3-DIHYDRO-1-METHYL-1H-ISOINDOLE MALEATE;2-((4,5-dihydro-1H-imidazol-2-yl)methyl)-2,3-dihydro-1-methyl-1H-isoindole BRL 44408
CBNumber: CB9159570
Molecular Formula: C13H17N3
Formula Weight: 215.29
MOL File: 118343-19-4.mol

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BRL 44408 MALEATE Property

Boiling point:: 365.8±30.0 °C(Predicted)
Density: 1.22±0.1 g/cm3(Predicted)
storage temp.: Desiccate at -20°C
solubility: H₂O: ~26 mg/mL, soluble
form: solid
pka: 10.29±0.40(Predicted)
color: off-white

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B4559
Product name: BRL 44408 maleate salt
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $187
Updated: 2024/03/01

Sigma-Aldrich

Product number: B4559
Product name: BRL 44408 maleate salt
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $789
Updated: 2024/03/01

Tocris

Product number: 1133
Product name: BRL44408maleate
Purity: ≥98%(HPLC)
Packaging: 10
Price: $173
Updated: 2021/12/16

Tocris

Product number: 1133
Product name: BRL44408maleate
Purity: ≥98%(HPLC)
Packaging: 50
Price: $724
Updated: 2021/12/16

TRC

Product number: B677680
Product name: BRL44408
Packaging: 100mg
Price: $1175
Updated: 2021/12/16

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BRL 44408 MALEATE Chemical Properties,Usage,Production

Uses

Selective a2A-adrenoceptor antagonist . Increases hippocampal noradrenaline release following systemic administration

Uses

Selective α2A-adrenoceptor antagonist . Increases hippocampal noradrenaline release following systemic administration.

Uses

BRL 44408 Maleate was used to study for norepinephrine reuptake modulators for preventing and treating vasomotor symptoms.

Biological Activity

Selective α 2A -adrenoceptor antagonist (K i = 1.7 nM and 144.5 nM at α 2A and α 2B -adrenergic receptors respectively). Increases hippocampal noradrenalin release following systemic administration. Also available as part of the α 2 -Adrenoceptor Tocriset™ .

Biochem/physiol Actions

BRL 44408 maleate is a selective α2A-adrenoceptor antagonist.

References

[1]. meana jj, callado lf, pazos a, et al. the subtype-selective alpha 2-adrenoceptor antagonists brl 44408 and arc 239 also recognize 5-ht1a receptors in the rat brain. eur j pharmacol, 1996, 312(3): 385-388.
[2]. owesson ca, seif i, mclaughlin dp, et al. different alpha(2) adrenoceptor subtypes control noradrenaline release and cell firing in the locus coeruleus of wildtype and monoamine oxidase-a knockout mice. eur j neurosci, 2003, 18(1): 34-42.
[3]. dwyer jm, platt bj, rizzo sj, et al. preclinical characterization of brl 44408: antidepressant- and analgesic-like activity through selective alpha2a-adrenoceptor antagonism. int j neuropsychopharmacol, 2010, 13(9): 1193-1205.

BRL 44408 MALEATE Preparation Products And Raw materials

Raw materials

Preparation Products

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BRL 44408 MALEATE Suppliers

Canada 1 China 34 Europe 1 Germany 2 India 2 Switzerland 1 United Kingdom 2 United States 6 Global 49

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DC Chemicals

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118343-19-4, BRL 44408 MALEATERelated Search:

BRL 44408 MALEATE

2-[(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)METHYL]-2,3-DIHYDRO-1-METHYL-1H-ISOINDOLE MALEATE

2-[2H-(1-METHYL-1,3-DIHYDROISOINDOLE)METHYL]-4,5-DIHYDROIMIDAZOLE MALEATE

BRL 44408 MALEATE

2-[[(1-Methyl-1,3-dihydro-2H-isoindol)-2-yl]methyl]-4,5-dihydro-1H-imidazole

Alendronate sodium trihydrate,4-amino-1-hydroxy-1-phosphonobutyl phosphonic acid, monosodium, MK-217

2-[(4,5-Dihydro-1H-imidazol-2-yl)methyl]-2,3-dihydro-1-methyl-1H-isoindole

BRL 44408

2-[2H-(1-Methyl-1,3-dihydroisoindole)methyl]-4,5-dihydroimidazole maleate salt

BRL 44408 maleate salt

2-((4,5-dihydro-1H-imidazol-2-yl)methyl)-2,3-dihydro-1-methyl-1H-isoindole BRL 44408

1H-Isoindole, 2-[(4,5-dihydro-1H-imidazol-2-yl)methyl]-2,3-dihydro-1-methyl-

118343-19-4

C17H21N3OD4

C13H17N3ClH

C13H17N3C4H4O4

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Adrenoceptor