BRL 44408 MALEATE
- Product Name
- BRL 44408 MALEATE
- CAS No.
- 118343-19-4
- Chemical Name
- BRL 44408 MALEATE
- Synonyms
- BRL 44408;BRL 44408 MALEATE;BRL 44408 maleate salt;2-[2H-(1-METHYL-1,3-DIHYDROISOINDOLE)METHYL]-4,5-DIHYDROIMIDAZOLE MALEATE;2-[(4,5-Dihydro-1H-imidazol-2-yl)methyl]-2,3-dihydro-1-methyl-1H-isoindole;2-[[(1-Methyl-1,3-dihydro-2H-isoindol)-2-yl]methyl]-4,5-dihydro-1H-imidazole;1H-Isoindole, 2-[(4,5-dihydro-1H-imidazol-2-yl)methyl]-2,3-dihydro-1-methyl-;2-[2H-(1-Methyl-1,3-dihydroisoindole)methyl]-4,5-dihydroimidazole maleate salt;2-[(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)METHYL]-2,3-DIHYDRO-1-METHYL-1H-ISOINDOLE MALEATE;2-((4,5-dihydro-1H-imidazol-2-yl)methyl)-2,3-dihydro-1-methyl-1H-isoindole BRL 44408
- CBNumber
- CB9159570
- Molecular Formula
- C13H17N3
- Formula Weight
- 215.29
- MOL File
- 118343-19-4.mol
BRL 44408 MALEATE Property
- Boiling point:
- 365.8±30.0 °C(Predicted)
- Density
- 1.22±0.1 g/cm3(Predicted)
- storage temp.
- Desiccate at -20°C
- solubility
- H2O: ~26 mg/mL, soluble
- form
- solid
- pka
- 10.29±0.40(Predicted)
- color
- off-white
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- B4559
- Product name
- BRL 44408 maleate salt
- Purity
- ≥98% (HPLC)
- Packaging
- 10mg
- Price
- $187
- Updated
- 2024/03/01
- Product number
- B4559
- Product name
- BRL 44408 maleate salt
- Purity
- ≥98% (HPLC)
- Packaging
- 50mg
- Price
- $789
- Updated
- 2024/03/01
- Product number
- 1133
- Product name
- BRL44408maleate
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $173
- Updated
- 2021/12/16
- Product number
- 1133
- Product name
- BRL44408maleate
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $724
- Updated
- 2021/12/16
- Product number
- B677680
- Product name
- BRL44408
- Packaging
- 100mg
- Price
- $1175
- Updated
- 2021/12/16
BRL 44408 MALEATE Chemical Properties,Usage,Production
Uses
Selective a2A-adrenoceptor antagonist . Increases hippocampal noradrenaline release following systemic administration
Uses
Selective α2A-adrenoceptor antagonist . Increases hippocampal noradrenaline release following systemic administration.
Uses
BRL 44408 Maleate was used to study for norepinephrine reuptake modulators for preventing and treating vasomotor symptoms.
Biological Activity
Selective α 2A -adrenoceptor antagonist (K i = 1.7 nM and 144.5 nM at α 2A and α 2B -adrenergic receptors respectively). Increases hippocampal noradrenalin release following systemic administration. Also available as part of the α 2 -Adrenoceptor Tocriset™ .
Biochem/physiol Actions
BRL 44408 maleate is a selective α2A-adrenoceptor antagonist.
References
[1]. meana jj, callado lf, pazos a, et al. the subtype-selective alpha 2-adrenoceptor antagonists brl 44408 and arc 239 also recognize 5-ht1a receptors in the rat brain. eur j pharmacol, 1996, 312(3): 385-388.
[2]. owesson ca, seif i, mclaughlin dp, et al. different alpha(2) adrenoceptor subtypes control noradrenaline release and cell firing in the locus coeruleus of wildtype and monoamine oxidase-a knockout mice. eur j neurosci, 2003, 18(1): 34-42.
[3]. dwyer jm, platt bj, rizzo sj, et al. preclinical characterization of brl 44408: antidepressant- and analgesic-like activity through selective alpha2a-adrenoceptor antagonism. int j neuropsychopharmacol, 2010, 13(9): 1193-1205.
BRL 44408 MALEATE Preparation Products And Raw materials
Raw materials
Preparation Products
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