ChemicalBook > CAS DataBase List > 2-(3,4-difluorophenyl)oxirane

2-(3,4-difluorophenyl)oxirane

Product Name: 2-(3,4-difluorophenyl)oxirane
CAS No.: 111991-13-0
Chemical Name: 2-(3,4-difluorophenyl)oxirane
Synonyms: Ticagrelor Impurity 101;(3,4-Difluorophenyl)oxirane;2-(3,4-difluorophenyl)oxirane;Oxirane, (3,4-difluorophenyl)-;Oxirane, 2-(3,4-difluorophenyl)-
CBNumber: CB91641672
Molecular Formula: C8H6F2O
Formula Weight: 156.13
MOL File: 111991-13-0.mol

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2-(3,4-difluorophenyl)oxirane Property

Boiling point:: 186.8±40.0 °C(Predicted)
Density: 1.335±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: D474415
Product name: 2-(3,4-Difluorophenyl)oxirane
Packaging: 50mg
Price: $45
Updated: 2021/12/16

AK Scientific

Product number: 5201AJ
Product name: 2-(3,4-Difluorophenyl)oxirane
Packaging: 1g
Price: $494
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0052141
Product name: 2-(3,4-DIFLUOROPHENYL)OXIRANE
Purity: 95.00%
Packaging: 1G
Price: $925.31
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0052141
Product name: 2-(3,4-DIFLUOROPHENYL)OXIRANE
Purity: 95.00%
Packaging: 2.5G
Price: $1363.65
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0052141
Product name: 2-(3,4-DIFLUOROPHENYL)OXIRANE
Purity: 95.00%
Packaging: 5G
Price: $1759.28
Updated: 2021/12/16

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2-(3,4-difluorophenyl)oxirane Chemical Properties,Usage,Production

Synthesis

405-03-8

111991-13-0

Under nitrogen protection, 14 g (100 mmol) of 3,4-difluorostyrene was dissolved in tetrahydrofuran. A 30% hydrogen peroxide solution (300 mmol) was slowly added dropwise at 20 °C, keeping the reaction temperature constant with continuous stirring for 4 hours. After completion of the reaction, water was added to the reaction mixture for stratification. The organic layer was separated and washed with appropriate amount of water. Subsequently, the organic layer was concentrated under reduced pressure and finally purified by column chromatography to afford 7.3 g of 2-(3,4-difluorophenyl)oxirane in 46.7% yield and 19.43% enantiomeric excess (ee) value.

References

[1] Patent: CN106631887, 2017, A. Location in patent: Paragraph 0034-0035

2-(3,4-difluorophenyl)oxirane Preparation Products And Raw materials

Raw materials

Preparation Products

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111991-13-0, 2-(3,4-difluorophenyl)oxiraneRelated Search:

(1S,2R)-2-(3,4-Difluorophenyl)-cyclopropanaMine (1S,2S,3R,5S)-3-(7-((1S,2R)-2-(3,4-difluorophenyl)cyclopropylaMino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyriMidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol (1S)-2-chloro-1-(3,4-difluorophenyl)-1-ethanol 2-[[(3aR,4S,6R,6aS)-6-(7-azanyl-5-propylsulfanyl-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyl-4,5,6,6a-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl]oxy]ethanol 1,2-Cyclopentanediol, 3-[7-aMino-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyriMidin-3-yl]-5-(2-hydroxyethoxy)-, (1S,2S,3R,5S)- CPABOC Ticagrelor Related Compound 8 2-(((1S,2S,3S,4R)-4-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl)oxy)ethyl acetate (1S,2S,3R,5S)-3-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)aMino)-5-(propylsulfinyl)-3H-[1,2,3]triazolo[4,5-d]pyriMidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol Ticagrelor iMpurity (1R,2R)-ethyl2-(3,4-difluorophenyl)cyclopropane carboxylate (1R,2R,3S,5R)-3-(7-((1S,2R)-2-(3,4-difluorophenyl)cyclopropylaMino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyriMidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol 1-Acetyladamantane Intermediate Ticagrelor Sulfone CyclopropanaMine, 2-(4-fluorophenyl)-(hydrochloride)(1:1),(1R,2S)- Ticagrelor Related Compound 38D-Tartrate Ticagrelor Cyclopropanamine, 2-(3-fluorophenyl)-, (1R,2S)- (9CI)

2-(3,4-difluorophenyl)oxirane

(3,4-Difluorophenyl)oxirane

Ticagrelor Impurity 101

Oxirane, (3,4-difluorophenyl)-

Oxirane, 2-(3,4-difluorophenyl)-

111991-13-0