ETHYL 5-AMINOBENZOFURAN-2-CARBOXYLATE

Product Name: ETHYL 5-AMINOBENZOFURAN-2-CARBOXYLATE
CAS No.: 174775-48-5
Chemical Name: ETHYL 5-AMINOBENZOFURAN-2-CARBOXYLATE
Synonyms: Vilazodone INT 5;ETHYL 5-AMINOBENZOFURAN-2-CARBOXYLAT;ETHYL 5-AMINOBENZOFURAN-2-CARBOXYLATE;5-Amino-2-(ethoxycarbonyl)-1-benzofura;5-Amino-2-(ethoxycarbonyl)-1-benzofuran;ethyle5-aminobenzo[b]furan-2-carboxylate;Ethyl 5-aminobenzo[b]furan-2-carboxylate;Ethyl 5-amino-1-benzofuran-2-carboxylate (en);Ethyl-5-amino--1-benzofuran-2-carboxylate Hcl;ETHYL 5-AMINOBENZOFURAN-2-CARBOXYLATE USP/EP/BP
CBNumber: CB9170159
Molecular Formula: C11H11NO3
Formula Weight: 205.21
MOL File: 174775-48-5.mol

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ETHYL 5-AMINOBENZOFURAN-2-CARBOXYLATE Property

Melting point:: 54-56°C
Boiling point:: 348.1±22.0 °C(Predicted)
Density: 1.258±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: soluble in Chloroform, DMSO
form: Powder
pka: 3.32±0.10(Predicted)
color: Beige

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Safety

Hazard Codes: Xi
HazardClass: IRRITANT
HS Code: 2932990090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: E1138
Product name: Ethyl 5-Aminobenzofuran-2-carboxylate
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $65
Updated: 2025/07/31

TCI Chemical

Product number: E1138
Product name: Ethyl 5-Aminobenzofuran-2-carboxylate
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $197
Updated: 2025/07/31

ChemScene

Product number: CS-M1412
Product name: Ethyl 5-Aminobenzofuran-2-carboxylate
Purity: 99.92%
Packaging: 25g
Price: $236
Updated: 2021/12/16

Chem-Impex

Product number: 42654
Product name: Ethyl5-aminobenzofuran-2-carboxylate,≥98%(GC)
Purity: ≥98%(GC)
Packaging: 5G
Price: $257.69
Updated: 2021/12/16

Matrix Scientific

Product number: 046141
Product name: Ethyl 5-amino-1-benzofuran-2-carboxylate
Purity: >95%
Packaging: 25g
Price: $350
Updated: 2021/12/16

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ETHYL 5-AMINOBENZOFURAN-2-CARBOXYLATE Chemical Properties,Usage,Production

Chemical Properties

Brown Solid

Uses

Ethyl 5-amino-1-benzofuran-2-carboxylate is used as an synthetic intermediate in the preparation of indolebutylpiperazines, a class of dual 5-HT1A receptor agonists and serotonin reuptake inhibitors. Ethyl 5-amino-1-benzofuran-2-carboxylate was also used as a potential radiolabelled analog for melanoma imaging and targeted radiotherapy.

Uses

Ethyl 5-aminobenzofuran-2-carboxylate is used as an synthetic intermediate in the preparation of indolebutylpiperazines, a class of dual 5-HT1A receptor agonists and serotonin reuptake inhibitors. Ethyl 5-amino-1-benzofuran-2-carboxylate was also used as a potential radiolabelled analog for melanoma imaging and targeted radiotherapy.

Synthesis

69604-00-8

174775-48-5

General procedure for the synthesis of ethyl 5-aminobenzofuran-2-carboxylate from ethyl 5-nitrobenzofuran-2-carboxylate: 20.0 g of ethyl 5-nitrobenzofuran-2-carboxylate was placed in a reaction flask and 300 mL of ethanol was added as a solvent. Subsequently, 2 g of 5% Pd/C catalyst was added. The reaction system was replaced twice with hydrogen to ensure that the reaction environment was a hydrogen atmosphere. The hydrogenation reaction was carried out for 3 hours by adjusting the hydrogen pressure to 0.3-0.5 MPa and controlling the reaction temperature in the range of 10-30°C. The reaction was carried out by filtration. Upon completion of the reaction, the catalyst was removed by filtration. The filtrate was concentrated under reduced pressure and dried to give 17.1 g of ethyl 5-aminobenzofuran-2-carboxylate in 98% yield.

References

[1] Patent: WO2013/153492, 2013, A2. Location in patent: Page/Page column 23
[2] Patent: US2015/87835, 2015, A1. Location in patent: Paragraph 0125
[3] ChemCatChem, 2014, vol. 6, # 11, p. 3153 - 3159
[4] Patent: CN107674052, 2018, A. Location in patent: Paragraph 0035-0037
[5] Patent: CN107540646, 2018, A. Location in patent: Paragraph 0041; 0042; 0043

ETHYL 5-AMINOBENZOFURAN-2-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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ETHYL 5-AMINOBENZOFURAN-2-CARBOXYLATE Suppliers

Americas 1 Belgium 1 Canada 2 China 192 Europe 2 France 1 Germany 3 India 39 Japan 1 Switzerland 1 The Netherlands 1 United Kingdom 5 United States 22 Global 271

J & K SCIENTIFIC LTD.

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View Lastest Price from ETHYL 5-AMINOBENZOFURAN-2-CARBOXYLATE manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: ETHYL 5-AMINOBENZOFURAN-2-CARBOXYLATE 174775-48-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2024-11-13

Shandong Kangmailin Chemical Technology Co. Ltd..

Product: Ethyl 5-aminobenzo[b]furan-2-carboxylate 174775-48-5
Price: US $1.00/Kg/Drum
Min. Order: 1KG
Purity: 99%
Supply Ability: 999tons
Release date: 2019-07-18

Career Henan Chemical Co

Product: ETHYL 5-AMINOBENZOFURAN-2-CARBOXYLATE 174775-48-5
Price: US $1200.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2018-07-24

174775-48-5, ETHYL 5-AMINOBENZOFURAN-2-CARBOXYLATERelated Search:

5-AMINO-BENZOFURAN-2-CARBOXYLIC ACID METHYL ESTER 2-Benzofurancarboxylic acid, 7-bromo-5-nitro-, ethyl ester ETHYL 5-NITROBENZOFURAN-2-CARBOXYLATE ETHYL 5-AMINOBENZOFURAN-2-CARBOXYLATE

ETHYL 5-AMINOBENZOFURAN-2-CARBOXYLATE

2-Benzofurancarboxylicacid,5-amino-,ethylester(9CI)

Ethyl 5-aminobenzo[b]furan-2-carboxylate

Ethyl 5-amino-1-benzofuran-2-carboxylate (en)

5-Amino-2-(ethoxycarbonyl)-1-benzofuran

5-Amino-2-(ethoxycarbonyl)-1-benzofuran, Ethyl 5-amino-1-benzofuran-2-carboxylate

ethyle5-aminobenzo[b]furan-2-carboxylate

5-Amino-2-(ethoxycarbonyl)-1-benzofura

2-Benzofurancarboxylicacid, 5-aMino-, ethyl ester

Vilazodone INT 5

ETHYL 5-AMINOBENZOFURAN-2-CARBOXYLAT

ETHYL 5-AMINOBENZOFURAN-2-CARBOXYLATE USP/EP/BP

2-Benzofurancarboxylic acid, 5-amino-, ethyl ester (9CI, ACI)

5-amino-2-Benzofurancarboxylic acid ethyl ester (9CI ACI)

Ethyl-5-amino--1-benzofuran-2-carboxylate Hcl

174775-48-5

Esters

Furans, Benzofurans & Dihydrobenzofurans

AMINOACID