3-(difluoromethoxy)pyridin-2-amine

Product Name: 3-(difluoromethoxy)pyridin-2-amine
CAS No.: 947249-14-1
Chemical Name: 3-(difluoromethoxy)pyridin-2-amine
Synonyms: 3-(difluoromethoxy)pyridin-2-amine;3-(Difluoromethoxy)-2-pyridinamine;2-Amino-3-(difluoromethoxy)pyridine;2-Pyridinamine, 3-(difluoromethoxy)-
CBNumber: CB91704564
Molecular Formula: C6H6F2N2O
Formula Weight: 160.12
MOL File: 947249-14-1.mol

More

Less

3-(difluoromethoxy)pyridin-2-amine Property

Boiling point:: 228.6±35.0 °C(Predicted)
Density: 1.331±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 7.36±0.10(Predicted)
Appearance: Off-white to brown Solid

More

Less

Safety

HS Code: 2933399990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TRC

Product number: D456355
Product name: 3-(Difluoromethoxy)pyridin-2-amine
Packaging: 50mg
Price: $65
Updated: 2021/12/16

Apolloscientific

Product number: PC448010
Product name: 3-(Difluoromethoxy)pyridin-2-amine
Purity: 95%
Packaging: 250mg
Price: $37
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-3-D8
Product name: 3-(Difluoromethoxy)pyridin-2-amine
Packaging: 250mg
Price: $60
Updated: 2021/12/16

Apolloscientific

Product number: PC448010
Product name: 3-(Difluoromethoxy)pyridin-2-amine
Purity: 95%
Packaging: 1g
Price: $110
Updated: 2021/12/16

AK Scientific

Product number: 8671BB
Product name: 3-(Difluoromethoxy)pyridin-2-amine
Packaging: 250mg
Price: $120
Updated: 2021/12/16

More

Less

3-(difluoromethoxy)pyridin-2-amine Chemical Properties,Usage,Production

Synthesis

1111637-77-4

947249-14-1

General procedure for the synthesis of 3-(difluoromethoxy)pyridin-2-amine from 3-(difluoromethoxy)-2-nitropyridine: 3-(difluoromethoxy)-2-nitropyridine (450 mg, 2.37 mmol) was dissolved in a mixed solvent of ethanol (2 mL) and acetic acid (2 mL) and reduced iron powder (397 mg, 7.10 mmol) was added. The reaction mixture was stirred at 100 °C overnight. Since the ingredients were not fully reacted, reduced iron powder (397 mg, 7.10 mmol) was added again and stirring was continued at 100 °C overnight. After completion of the reaction, the mixture was filtered through diatomaceous earth and the filtrate was concentrated under reduced pressure. To the concentrated residue was added saturated aqueous sodium bicarbonate and extracted three times with ethyl acetate. The organic layers were combined, dried with anhydrous magnesium sulfate, filtered and purified by silica gel column chromatography (eluent: chloroform/methanol=9/1, v/v) to afford the target product 3-(difluoromethoxy)pyridin-2-amine (250 mg, 66% yield). The product was detected by electrospray ionization mass spectrometry (ESIMS), m/z: 161 (M + H)+; 1H NMR (270 MHz, CDCl3, δ): 4.79 (broad single peak, 2H), 6.14-6.80 (multiple peaks, 2H), 7.19-7.35 (multiple peaks, 1H), 7.85-7.98 (multiple peaks, 1H).

References

[1] Patent: WO2010/100127, 2010, A1. Location in patent: Page/Page column 73
[2] Patent: WO2009/16460, 2009, A2. Location in patent: Page/Page column 55-56
[3] Patent: EP2740730, 2014, A1. Location in patent: Paragraph 0346
[4] Patent: WO2014/111496, 2014, A1. Location in patent: Page/Page column 108
[5] Patent: WO2015/91889, 2015, A1. Location in patent: Page/Page column 73; 74

3-(difluoromethoxy)pyridin-2-amine Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

3-(difluoromethoxy)pyridin-2-amine Suppliers

China 34 India 1 Ukraine 1 United Kingdom 1 United States 2 Global 39

HANGZHOU HETE CHEMICAL TECHNOLOGY CO.,LTD

Tel: 571-89189769 15168342188
Fax: 0571-86205065
Country: China
ProdList: 229
Advantage: 62

Cochemical Ltd.

Tel: 029-86115547 17791676824
Fax: 02151602123
Email: sales@cochemical.com
Country: China
ProdList: 3014
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

ShangHai AmK Pharmaceutical Technology Co., Ltd.

Tel: 微信 17321281695 18019252918
Fax: 17321281695
Email: sale@amkchem.com
Country: China
ProdList: 15136
Advantage: 55

skychemical Co.Ltd

Tel: 021-20960837,QQ1332204249
Fax: 021-20960837
Email: sales@skychemical.com
Country: China
ProdList: 3341
Advantage: 55

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Sichuan BaiPeng Biotechnology Co., Ltd.

Tel: 028-65791793 18140026355
Fax: QQ568470422
Email: 568470422@qq.com
Country: China
ProdList: 9997
Advantage: 58

Wuxi AppTec

Tel: 022-59987777 13552403979
Email: jia_guoqiang@wuxiapptec.com
Country: China
ProdList: 22345
Advantage: 58

Aikon International Limited

Tel: 025-58851090 15955137747
Fax: (6)02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 15949
Advantage: 58

3A Chemicals

Tel: 400-668-9898
Fax: 010-51582189
Email: service@3achem.com
Country: China
ProdList: 20557
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Henan Alpha Chemical Co., Ltd.

Tel: 0371-55055611 18137792234
Fax: QQ：3002694073
Email: 3002694073@qq.com
Country: China
ProdList: 9987
Advantage: 58

Henan Alfa Chemical Co., Ltd

Tel: +8615838112936
Email: alfa10@alfachem.cn
Country: China
ProdList: 12921
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: +86-0571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52846
Advantage: 58

Ningbo Benkang jishi Pharmaceutical Technology Co., Ltd.

Tel: 15990591583
Fax: qq: 1050376806 mailbox : sales@nbpharmabridge.com
Country: China
ProdList: 6108
Advantage: 58

Jinan ponder chemical co. LTD

Tel: 0531-0000
Email: thinklifescience@163.com
Country: China
ProdList: 19689
Advantage: 58

Shanghai Sunway Pharmaceutical Technology Co.,Ltd.

Tel: 021-51816796-820 13611835272
Fax: 021-5161 3951
Email: sales2@sunwaypharm.com
Country: China
ProdList: 44119
Advantage: 58

Xi'an Zhenghao Biotechnology Co., Ltd

Tel: 19829389091
Fax: QQ:399787610
Email: 399787610@qq.com
Country: China
ProdList: 2575
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Country: China
ProdList: 40000
Advantage: 58

PharmaBlock Sciences (Nanjing), Inc.

Tel: 4000255188
Fax: 025 86918232
Email: sales_china@pharmablock.com
Country: China
ProdList: 10000
Advantage: 58

Shaanxi Yudingzhuo Medical Technology Co., Ltd.

Tel: 18992018580 18165105898
Fax: QQ:1617857088
Email: 13608210612@163.com
Country: China
ProdList: 2984
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-6005915
Email: sales@picasso-e.com
Country: China
ProdList: 39665
Advantage: 58

Beijing InnoChem Science & Technology Co., Ltd.

Tel: 15652467323
Email: sales@inno-chem.com.cn
Country: China
ProdList: 8293
Advantage: 58

Suzhou Meishi Biotechnology Co., Ltd.

Tel: 1173954148q
Email: meishipharma@126.com
Country: China
ProdList: 20033
Advantage: 58

Shaanxi PharmaGHS Science Co., LTD

Tel: 13279368192
Email: pharmaghs@126.com
Country: China
ProdList: 2935
Advantage: 58

PharmaBlock Sciences (Nanjing), Inc.

Tel: 4000255188
Email: marketing@pharmablock.com
Country: China
ProdList: 9126
Advantage: 58

Shanghai Silan Pharmaceutical Technology Co. , Ltd.

Tel: 17301772648
Email: 3153252124@qq.com
Country: China
ProdList: 401
Advantage: 58

https://hanhongsci.com/

Tel: 021-54306202 18917919676
Email: info@hanhongsci.com
Country: China
ProdList: 29995
Advantage: 58

Huanuo Pharmaceutical Technology (Guangxi) Co., Ltd

Tel: 13005928603
Email: 211017228@qq.com
Country: China
ProdList: 8277
Advantage: 58

Baoji Didu Pharmaceutical and Chemical Co., Ltd

Tel: 029-029-81148929 17791530722
Email: 1049@dideu.com
Country: China
ProdList: 10011
Advantage: 58

Biosynth Biological Technology (Suzhou) Co Ltd

Tel: 51288865780
Email: sales@biosynth.com
Country: China
ProdList: 6051
Advantage: 58

Suzhou ARTK Medchem Co., Ltd.

Tel: +86-512-68323658 +86-18168183658
Email: sales1@artkmedchem.com
Country: China
ProdList: 39002
Advantage: 58

Cochemical Co. Ltd.

Tel: +86-029-86115547 +86-17791676824
Email: sales@cochemical.com
Country: China
ProdList: 3952
Advantage: 58

PT CHEM GROUP LIMITED

Tel: +86-85511178;
Email: peter68@ptchemgroup.com
Country: China
ProdList: 35425
Advantage: 58

947249-14-1, 3-(difluoromethoxy)pyridin-2-amineRelated Search:

3-(difluoromethoxy)pyridin-2-amine

2-Amino-3-(difluoromethoxy)pyridine

3-(Difluoromethoxy)-2-pyridinamine

2-Pyridinamine, 3-(difluoromethoxy)-

947249-14-1