ChemicalBook > CAS DataBase List > 4ALPHA-PHORBOL 12,13-DIDECANOATE

4ALPHA-PHORBOL 12,13-DIDECANOATE

Product Name
4ALPHA-PHORBOL 12,13-DIDECANOATE
CAS No.
27536-56-7
Chemical Name
4ALPHA-PHORBOL 12,13-DIDECANOATE
Synonyms
4a-PDD;4ALPHA-PDD;4α-Phorbol 12;13-didecanoate;4alphaPDD,4alpha PDD;-Phorbol12,13-didecanoate;4α-phorbol 12-13-dicaprinate;4a-Phorbol-12,13-didecanoate;4α-Phorbol 12,13-didecanoate;4alpha-Phorbol 12,13-dideconate
CBNumber
CB9171479
Molecular Formula
C40H64O8
Formula Weight
672.93
MOL File
27536-56-7.mol
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4ALPHA-PHORBOL 12,13-DIDECANOATE Property

storage temp. 
-20°C
solubility 
DMSO: soluble
form 
solid
color 
white
BRN 
2514324
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Safety

Hazard Codes 
T+
Risk Statements 
26/27/28-40-43
Safety Statements 
36/37/39-45
RIDADR 
UN 2811 6.1/PG 2
WGK Germany 
3
F 
8-10
HazardClass 
6.1(b)
PackingGroup 
III
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

H317May cause an allergic skin reaction

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H351Suspected of causing cancer

Precautionary statements

P201Obtain special instructions before use.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
524394
Product name
4α-Phorbol-12,13-didecanoate
Packaging
1mg
Price
$125
Updated
2024/03/01
Sigma-Aldrich
Product number
524394
Product name
4α-Phorbol-12,13-didecanoate
Packaging
5mg
Price
$476
Updated
2024/03/01
Cayman Chemical
Product number
20446
Product name
4α-Phorbol 12,13-didecanoate
Purity
≥99%
Packaging
1mg
Price
$100
Updated
2024/03/01
Cayman Chemical
Product number
20446
Product name
4α-Phorbol 12,13-didecanoate
Purity
≥99%
Packaging
5mg
Price
$425
Updated
2024/03/01
Sigma-Aldrich
Product number
P8014
Product name
4α-Phorbol 12,13-didecanoate
Purity
solid
Packaging
1mg
Price
$204
Updated
2024/03/01
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4ALPHA-PHORBOL 12,13-DIDECANOATE Chemical Properties,Usage,Production

Uses

4α-Phorbol 12,13-didecanoate has been used as a transient receptor potential vanilloid 4 (TRPV4) agonist:

  • to study its effects on Madin-Darby canine kidney (MDCK) cells
  • to study its effects on Ca2+ influx in mice fallopian tubal cells
  • to study its effects on hind paw swelling in mice

Definition

ChEBI: 4alpha-phorbol 12,13-didecanoate is a phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted to the corresponding decanoate esters. A Trpv4-specific ligand. It has a role as a TRPV4 agonist. It is a phorbol ester, a decanoate ester, a tertiary alpha-hydroxy ketone, a diester and a primary allylic alcohol.

Biochem/physiol Actions

4α-Phorbol 12,13-didecanoate is a transient receptor potential vanilloid 4 (TRPV4) agonist. It promotes extracellular calcium influx into the cells.

4ALPHA-PHORBOL 12,13-DIDECANOATE Preparation Products And Raw materials

Raw materials

Preparation Products

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4ALPHA-PHORBOL 12,13-DIDECANOATE Suppliers

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27536-56-7, 4ALPHA-PHORBOL 12,13-DIDECANOATERelated Search:

Citronellol (R)-(+)-BETA-CITRONELLOL Dihydromyrcene 1-Methylcyclohexanol CYCLOHEPTENE (-)-CITRONELLAL Isoamyl butyrate (R)-(+)-1,2-OCTANEDIOL 2,4-DIMETHYL-4-PENTEN-2-OL CIS-4-DECEN-1-OL 2-ETHYLHEXYL BUTYRATE N-CAPRIC ACID N-HEPTYL ESTER N-CAPRYLIC ACID ISOBUTYL ESTER CYCLODODECENE 2-METHYLCARBAZOLE 2-ETHYLHEXYL PELARGONATE RHODINYL ACETATE 2,4-dimethylnonan-4-ol

  • 4ALPHA-PDD
  • 4ALPHA-PHORBOL 12-13-DICAPRINATE
  • 4ALPHA-PHORBOL 12,13-DIDECANOATE
  • 4a-Phorbol-12,13-didecanoate
  • 4A-PHORBOL 12,13-DIDECANOATE WEAK PROTEI N KINASE C
  • 4α-phorbol 12-13-dicaprinate
  • 4A-PHORBOL 12,13-DIDECANOATE, 99+%
  • phorbol (4alpha-) 12,13-didecanoate
  • 4α-Phorbol 12-13-dicaprinate, 4αPDD
  • 4alpha-Phorbol 12,13-dideconate
  • Decanoic acid, 1,1A,1B,4,4A,5,7A,7B,8,9-decahydro-4A,7B-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-9ah-cyclopropa(3,4)benz(1,2-E)azulene-9,9A-diyl ester, (1ar-(1aalpha,1bbeta,4aalpha,7aalpha,7balpha,8alpha,9beta,9aalpha))-
  • 4-alpha-Phorbol 12,13-Didecanoate >99%
  • 4α-Phorbol 12,13-Didecanoate, >99%
  • 4a-PDD
  • 4α-Phorbol-12,13-didecanoate - CAS 27536-56-7 - Calbiochem
  • Decanoic acid, 1,1'-[(1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-9aH-cyclopropa[3,4]benz[1,2-e]azulene-9,9a-diyl] ester
  • 4α-Phorbol 12,13-didecanoate
  • -Phorbol12,13-didecanoate
  • 13-didecanoate
  • 4α-Phorbol 12
  • 4alphaPDD,4alpha PDD
  • 4alpha-Phorbol 12,13-didecanoate solid
  • 27536-56-7
  • C40H64O8
  • Kinase/Phosphatase Biology
  • Serine/Threonine Kinase Activators
  • Protein Kinase C (PKC)
  • Cell Signaling and Neuroscience
  • Cell Biology
  • BioChemical
  • metabolite