ChemicalBook > CAS DataBase List > 8-CHLORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE

8-CHLORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE

Product Name: 8-CHLORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE
CAS No.: 61563-33-5
Chemical Name: 8-CHLORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE
Synonyms: 8-CHLORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HCL;8-CHLORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE
CBNumber: CB9172416
Molecular Formula: C9H11Cl2N
Formula Weight: 204.1
MOL File: 61563-33-5.mol

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8-CHLORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: C433410
Product name: 8-Chloro-1,2,3,4-tetrahydroisoquinolinehydrochloride
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: C433410
Product name: 8-Chloro-1,2,3,4-tetrahydroisoquinolinehydrochloride
Packaging: 500mg
Price: $220
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC143159
Product name: 8-Chloro-1,2,3,4-tetrahydroisoquinoline hydrochloride
Packaging: 250mg
Price: $275
Updated: 2021/12/16

Ark Pharm

Product number: P000588336
Product name: 8-Chloro-1,2,3,4-tetrahydroisoquinoline hydrochloride
Purity: 95%
Packaging: 10g
Price: $417
Updated: 2021/12/16

Ark Pharm

Product number: P000588336
Product name: 8-Chloro-1,2,3,4-tetrahydroisoquinoline hydrochloride
Purity: 95%
Packaging: 1g
Price: $75
Updated: 2021/12/16

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8-CHLORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE Chemical Properties,Usage,Production

Synthesis

64834-58-8

61563-33-5

General procedure for the synthesis of 8-chloro-1,2,3,4-tetrahydroisoquinoline hydrochloride from 2-(2-chloro-benzylamino)-ethanol: To a mixture of 2-(2-chloro-benzylamino)-ethanol (10.00 g, 45.05 mmol) and ammonium chloride (1.76 g, 32.9 mmol) was added, at 185°C, aluminum chloride (11.60 g, 87.02 mmol). After 40 and 70 minutes of reaction, additional portions of aluminum chloride (5.80 g, 43.5 mmol and 11.60 g, 87.02 mmol) were added and the mixture continued to be stirred at the same temperature. The reaction mixture was poured into a slurry of ice and 3M HCl solution under strong stirring. The resulting solution was alkalized to pH 14 with 40% NaOH solution and subsequently extracted with ether (300 mL and 2 x 150 mL). The organic layers were combined, dried with anhydrous magnesium sulfate, and the solvent was evaporated to give an oily residue (7.07 g, 94%) containing both isomers (9:1 ratio, as determined by GC-MS). The oily substance was dissolved in isopropanol (50 mL) and the isopropanol solution of hydrochloric acid gas was added dropwise. The precipitate was collected by filtration and the residue was recrystallized twice with isopropanol to give 8-chloro-1,2,3,4-tetrahydroisoquinoline hydrochloride (2.32 g, 25%) as a light brown solid. Melting point 244-246 °C (isopropanol, off-white solid).IR (KBr): ν= 3423, 1587, 1468 cm-1.1H NMR (400 MHz, CD3OD): δ= 7.37 (br d, J = 7.7Hz, 1H), 7.31 (t, J = 7.7Hz, 1H), 7.24 (br d, J = 7.7Hz. 1H), 4.37 (s, 2H), 3.49 (t, J = 6.3 Hz, 2H), 3.14 (br t, J = 6.3 Hz, 2H).13C NMR (100 MHz, CD3OD): δ= 135.6, 133.3, 130.2, 129.0, 128.8, 127.3, 43.9, 42.2, 26.2. HRMS calculated value C9H11ClN + ([M + H] +): 168.0575, measured value: 168.0580.

References

[1] Tetrahedron, 2018, vol. 74, # 49, p. 7009 - 7017

8-CHLORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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8-CHLORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE Suppliers

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View Lastest Price from 8-CHLORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE manufacturers

Career Henan Chemical Co

Product: 8-CHLORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE 61563-33-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-12-20

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61563-33-5