5-amino-1-(pyridin-2-yl)-1H-pyrazole-4-carbonitrile
- Product Name
- 5-amino-1-(pyridin-2-yl)-1H-pyrazole-4-carbonitrile
- CAS No.
- 72816-14-9
- Chemical Name
- 5-amino-1-(pyridin-2-yl)-1H-pyrazole-4-carbonitrile
- Synonyms
- 5-Amino-1-(pyridin-2-yl);5-Amino-4-cyano-1-(2-pyridyl)pyrazole;5-Amino-1-(2-pyridyl)pyrazole-4-carbonitrile;5-amino-1-pyridin-2-ylpyrazole-4-carbonitrile;5-amino-1-(pyridin-2-yl)-1H-pyrazole-4-carbonitrile;1H-Pyrazole-4-carbonitrile, 5-amino-1-(2-pyridinyl)-
- CBNumber
- CB91773164
- Molecular Formula
- C9H7N5
- Formula Weight
- 185.19
- MOL File
- 72816-14-9.mol
5-amino-1-(pyridin-2-yl)-1H-pyrazole-4-carbonitrile Property
- Density
- 1.37
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- Appearance
- Light brown to brown Solid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- A898818
- Product name
- 5-Amino-1-(pyridin-2-yl)-1H-pyrazole-4-carbonitrile
- Packaging
- 500mg
- Price
- $310
- Updated
- 2021/12/16
- Product number
- 101554
- Product name
- 5-Amino-1-(pyridin-2-yl)-1H-pyrazole-4-carbonitrile
- Purity
- 98%
- Packaging
- 1g
- Price
- $157
- Updated
- 2021/12/16
- Product number
- 3H37-1-2K
- Product name
- 5-Amino-1-(pyridin-2-yl)-1H-pyrazole-4-carbonitrile
- Packaging
- 1g
- Price
- $436
- Updated
- 2021/12/16
- Product number
- 8829AE
- Product name
- 5-Amino-1-(pyridin-2-yl)-1H-pyrazole-4-carbonitrile
- Packaging
- 10g
- Price
- $871
- Updated
- 2021/12/16
- Product number
- 101554
- Product name
- 5-Amino-1-(pyridin-2-yl)-1H-pyrazole-4-carbonitrile
- Purity
- 98%
- Packaging
- 250mg
- Price
- $66
- Updated
- 2021/12/16
5-amino-1-(pyridin-2-yl)-1H-pyrazole-4-carbonitrile Chemical Properties,Usage,Production
Synthesis
4930-98-7
123-06-8
72816-14-9
To 2-hydrazinopyridine (3.00 g, 27.5 mmol) and ethoxymethylene malononitrile (3.37 g, 27.5 mmol) in 50 mL of ethanol, triethylamine (3.8 mL, 27.5 mmol) was added. The reaction mixture was heated to reflux for about 3.5 hours. After completion of the reaction, it was cooled to room temperature and the precipitated solid was collected to afford the white solid product 5-amino-1-(2-pyridyl)-1H-pyrazole-4-carbonitrile (4.33 g, 85% yield). The product was characterized by 1H NMR (DMSO-d6): δ 8.46 (dd, 1H), 8.11 (brs, 2H), 8.01 (m, 1H), 7.88 (s, 1H), 7.84 (d, 1H), 7.35 (m, 1H) ppm.
References
[1] Patent: WO2004/9597, 2004, A2. Location in patent: Page 21
[2] European Journal of Organic Chemistry, 2018, vol. 2018, # 13, p. 1514 - 1524
[3] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 9, p. 2121 - 2125
[4] Organic and Biomolecular Chemistry, 2007, vol. 5, # 17, p. 2758 - 2761
[5] Patent: US2007/161662, 2007, A1
5-amino-1-(pyridin-2-yl)-1H-pyrazole-4-carbonitrile Preparation Products And Raw materials
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