ChemicalBook > CAS DataBase List > tert-butyl 6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate

tert-butyl 6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate

Product Name
tert-butyl 6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate
CAS No.
230301-73-2
Chemical Name
tert-butyl 6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate
Synonyms
5-Boc-4,5,6,7-tetrahydrothieno[3,2-c]pyridine;tert-Butyl 6,7-dihydrothieno[3,2-c]pyridine-5(4H);tert-butyl 4H,5H,6H,7H-thieno[3,2-c]pyridine-5-carboxylate;tert-butyl 6,7-dihydrothieno[3,2-c]pyridin-5(4H)-carboxylate;tert-butyl 6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate;tert-butyl 6,7-dihydro-4H-thieno[3,2-c]pyridine-5-carboxylate;1,1-Dimethylethyl 6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate;6,7-dihydro-4H-thieno[3,2-c]-pyridine-5-carboxylic acid tert-butyl ester;Thieno[3,2-c]pyridine-5(4H)-carboxylic acid, 6,7-dihydro-, 1,1-diMethylethyl ester
CBNumber
CB91856209
Molecular Formula
C12H17NO2S
Formula Weight
239.33
MOL File
230301-73-2.mol
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tert-butyl 6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate Property

Boiling point:
339.1±42.0 °C(Predicted)
Density 
1.173
storage temp. 
2-8°C(protect from light)
pka
-1.51±0.20(Predicted)
Appearance
White to off-white Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B699833
Product name
tert-Butyl6,7-Dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate
Packaging
50mg
Price
$45
Updated
2021/12/16
TRC
Product number
B699833
Product name
tert-Butyl6,7-Dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate
Packaging
100mg
Price
$60
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB144251
Product name
tert-Butyl 6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate
Packaging
500mg
Price
$95
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB144251
Product name
tert-Butyl 6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate
Packaging
1g
Price
$162
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB144251
Product name
tert-Butyl 6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate
Packaging
250mg
Price
$52.5
Updated
2021/12/16
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tert-butyl 6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate Chemical Properties,Usage,Production

Synthesis

24424-99-5

28783-41-7

230301-73-2

The general procedure for the synthesis of tert-butyl 6,7-dihydrothieno[3,2-C]pyridine-5(4H)-carboxylate from 4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride (5 g, 28.46 mmol) and di-tert-butyl dicarbonate (6.83 g, 31.30 mmol) is as follows: 4,5,6,7-tetrahydrothieno[3,2-c] pyridine hydrochloride was suspended in 150 mL of dichloromethane, triethylamine (3.17 g, 31.30 mmol) was added followed by slow addition of solid di-tert-butyl dicarbonate. The reaction mixture was stirred at room temperature for 2 hours. After completion of the reaction, the organic phase was washed sequentially with water (2 x 100 mL) and brine (2 x 100 mL), dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated under reduced pressure to give a colorless oily product (6.8 g, 100% yield), which solidified to a white solid on standing.

References

[1] Patent: WO2009/49028, 2009, A1. Location in patent: Page/Page column 156
[2] Patent: CN104497008, 2016, B. Location in patent: Paragraph 0190; 0192; 0193
[3] Journal of Medicinal Chemistry, 2014, vol. 57, # 9, p. 3687 - 3706
[4] Patent: CN104341433, 2017, B. Location in patent: Paragraph 0036; 0037

tert-butyl 6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-butyl 6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate Suppliers

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230301-73-2, tert-butyl 6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylateRelated Search:

TERT-BUTYL 7-CHLORO-3,4-DIHYDRO-4-OXOQUINOLINE-1(2H)-CARBOXYLATE TERT-BUTYL 4-(4-NITROBENZOYL)TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE tert-butyl 4-(4-bromophenyl)-5,6-dihydropyridine-1(2H)-carboxylate TERT-BUTYL 6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDINE-5(4H)-CARBOXYLATE 5H-CYCLOPENTA[B]PYRIDIN-7-AMINE, 6,7-DIHYDRO- 5H-Cyclopentapyrimidin-2-amine, 6,7-dihydro- (9CI) ethyl 6,8-difluoroH-iMidazo[1,2-a]pyridine-2-carboxylate Diethyl 6,7-dihydrothieno[3,2-c]pyridine-2,5(4H)-dicarboxylate ethyl 6,8-dichloroimidazo[1,2-a]pyridine-2-carboxylate 6,7-Dihydro-5H-cyclopenta[b]pyridine 1-oxide Carbamic acid, N-[(1R)-2,2,2-trifluoro-1-(hydroxymethyl)ethyl]-, 1,1-dimethylethyl ester TERT-BUTYL 3-(4-BROMOPHENYL)PYRROLIDINE-1-CARBOXYLATE tert-butyl 4-methoxybenzylcarbamate TERT-BUTYL 2-VINYLPIPERIDINE-1-CARBOXYLATE (S)-tert-butyl (1-hydroxypent-4-en-2-yl)carbamate 2-(Boc-amino)-2-cyclopropylethanol Carbamic acid, (1-ethyl-3-hydroxypropyl)-, 1,1-dimethylethyl ester (9CI) Carbamic acid, N-(4-cyano-2,3-dihydro-1H-inden-1-yl)-, 1,1-dimethylethyl ester

  • tert-butyl 6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate
  • tert-butyl 4H,5H,6H,7H-thieno[3,2-c]pyridine-5-carboxylate
  • Thieno[3,2-c]pyridine-5(4H)-carboxylic acid, 6,7-dihydro-, 1,1-diMethylethyl ester
  • 6,7-dihydro-4H-thieno[3,2-c]-pyridine-5-carboxylic acid tert-butyl ester
  • tert-butyl 6,7-dihydrothieno[3,2-c]pyridin-5(4H)-carboxylate
  • tert-butyl 6,7-dihydro-4H-thieno[3,2-c]pyridine-5-carboxylate
  • tert-Butyl 6,7-dihydrothieno[3,2-c]pyridine-5(4H)
  • 5-Boc-4,5,6,7-tetrahydrothieno[3,2-c]pyridine
  • 1,1-Dimethylethyl 6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate
  • 230301-73-2
  • Heterocycle-Pyridine series
  • CHIRAL CHEMICALS