Benzonitrile, 2-chloro-3-hydroxy-
- Product Name
- Benzonitrile, 2-chloro-3-hydroxy-
- CAS No.
- 51786-11-9
- Chemical Name
- Benzonitrile, 2-chloro-3-hydroxy-
- Synonyms
- 2 - chloro - 3 - cyanophenol;Benzonitrile, 2-chloro-3-hydroxy-
- CBNumber
- CB91862406
- Molecular Formula
- C7H4ClNO
- Formula Weight
- 153.57
- MOL File
- 51786-11-9.mol
Benzonitrile, 2-chloro-3-hydroxy- Property
- Boiling point:
- 273.7±25.0 °C(Predicted)
- Density
- 1.41±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 7.11±0.10(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2926907090
N-Bromosuccinimide Price
- Product number
- CS-W021640
- Product name
- 2-Chloro-3-hydroxybenzonitrile
- Purity
- >97.0%
- Packaging
- 250mg
- Price
- $64
- Updated
- 2021/12/16
- Product number
- CS-W021640
- Product name
- 2-Chloro-3-hydroxybenzonitrile
- Purity
- >97.0%
- Packaging
- 1g
- Price
- $163
- Updated
- 2021/12/16
- Product number
- 7241AB
- Product name
- 2-Chloro-3-hydroxybenzonitrile
- Packaging
- 1g
- Price
- $303
- Updated
- 2021/12/16
- Product number
- OR939696
- Product name
- 2-Chloro-3-hydroxybenzonitrile
- Purity
- 95%
- Packaging
- 1g
- Price
- $450
- Updated
- 2021/12/16
- Product number
- HCH0068882
- Product name
- 2-CHLORO-3-HYDROXYBENZONITRILE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.85
- Updated
- 2021/12/16
Benzonitrile, 2-chloro-3-hydroxy- Chemical Properties,Usage,Production
Synthesis
853331-52-9
51786-11-9
General procedure for the synthesis of 2-chloro-3-hydroxybenzonitrile from 2-chloro-3-methoxybenzonitrile: Iodocyclohexane (3.86 mL, 29.83 mmol) was slowly added to a solution of DMF (10 mL) containing 2-chloro-3-methoxybenzonitrile (1 g, 5.97 mmol) at 20 °C under nitrogen protection. The reaction mixture was heated to 155 °C with continuous stirring for 7 hours. After the reaction was completed, it was cooled to room temperature and the mixture was poured into water. Extraction was carried out with ethyl acetate (2 x 50 mL), the organic phases were combined and washed with brine (50 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the crude product. The crude product was ground with dichloromethane and the resulting solid was collected by filtration and dried under vacuum to give 2-chloro-3-hydroxybenzonitrile (0.510 g, 55.7% yield) as a white solid. No additional product was obtained from the filtrate treatment. The product was confirmed by 1H NMR (400 MHz, DMSO): δ 7.25-7.39 (3H, m), 11.00 (1H, s). The mass spectrum (ES-) showed m/z (M-H)- = 152.
References
[1] Patent: WO2011/121350, 2011, A1. Location in patent: Page/Page column 105
[2] Patent: WO2010/56631, 2010, A1. Location in patent: Page/Page column 146
Benzonitrile, 2-chloro-3-hydroxy- Preparation Products And Raw materials
Raw materials
Preparation Products
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