b-Alanine, N-[4-[(1S)-1-[3-(3,5-dichlorophenyl)-5-(6-methoxy-2-naphthalenyl)-1H-pyrazol-1-yl]ethyl]benzoyl]-

Product Name: b-Alanine, N-[4-[(1S)-1-[3-(3,5-dichlorophenyl)-5-(6-methoxy-2-naphthalenyl)-1H-pyrazol-1-yl]ethyl]benzoyl]-
CAS No.: 870823-12-4
Chemical Name: b-Alanine, N-[4-[(1S)-1-[3-(3,5-dichlorophenyl)-5-(6-methoxy-2-naphthalenyl)-1H-pyrazol-1-yl]ethyl]benzoyl]-
Synonyms: MK 0893;MK0893;MK 0893;Merk Glucagon antagonist;Merck Glucagon Receptor Antagonist;(S)-3-(4-(1-(3-(3,5-Dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)-1H-pyrazol-1-yl)ethyl)benzami;(S)-3-(4-(1-(3-(3,5-Dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)-1H-pyrazol-1-yl)ethyl)benzamido);β-Alanine, N-[4-[(1S)-1-[3-(3,5-dichlorophenyl)-5-(6-methoxy-2-naphthalenyl)-1H-pyrazol-1-yl]ethyl]benzoyl]-;b-Alanine, N-[4-[(1S)-1-[3-(3,5-dichlorophenyl)-5-(6-methoxy-2-naphthalenyl)-1H-pyrazol-1-yl]ethyl]benzoyl]-;N-[4-[(1S)-1-[3-(3,5-Dichlorophenyl)-5-(6-methoxy-2-naphthalenyl)-1H-pyrazol-1-yl]ethyl]benzoyl]-beta-alanine
CBNumber: CB91871952
Molecular Formula: C32H27Cl2N3O4
Formula Weight: 588.48
MOL File: 870823-12-4.mol

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b-Alanine, N-[4-[(1S)-1-[3-(3,5-dichlorophenyl)-5-(6-methoxy-2-naphthalenyl)-1H-pyrazol-1-yl]ethyl]benzoyl]- Property

Boiling point:: 814.0±65.0 °C(Predicted)
Density: 1.33
storage temp.: Store at -20°C
solubility: ≥24.05 mg/mL in DMSO; insoluble in H2O; ≥4.8 mg/mL in EtOH with gentle warming and ultrasonic
form: solid
pka: 4.28±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology

Product number: A3608
Product name: MK0893
Packaging: 5mg
Price: $315
Updated: 2021/12/16

ApexBio Technology

Product number: A3608
Product name: MK0893
Packaging: 10mM(in 1mL DMSO)
Price: $410
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0028177
Product name: MK-0893
Purity: 95.00%
Packaging: 5MG
Price: $502.27
Updated: 2021/12/16

ApexBio Technology

Product number: A3608
Product name: MK0893
Packaging: 10mg
Price: $570
Updated: 2021/12/16

ChemScene

Product number: CS-0324
Product name: MK0893
Purity: 99.33%
Packaging: 10mg
Price: $684
Updated: 2021/12/16

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b-Alanine, N-[4-[(1S)-1-[3-(3,5-dichlorophenyl)-5-(6-methoxy-2-naphthalenyl)-1H-pyrazol-1-yl]ethyl]benzoyl]- Chemical Properties,Usage,Production

Biological Activity

mk 0893 is an inhibitor of both glucagon receptor and igf-1r with ic50 values of 6.6nm and 6nm, respectively [1, 2].in a receptor binding assay using a membrane preparation from a cho cell line expressing the human gcgr, mk 0893 is shown to inhibit the bing between glucagon and the gcgr(ic50 value of 6.6 ± 3.5nm) and subsequently induce camp production(ic50 value of 15.7 ± 5.4nm). mk 0893 is proved to be a competitive, reversible gcgr antagonist, as evidenced by schild analysis in this cell line. and in an acute glucagon challenge model in hgcgr mice, mk 0893 is found to be active in blunting glucagon-induced glucose excursion. all these effects make mk 0893 be a potential oral treatment for type 2 diabetes. additionally, mk 0893 is also reported as a potent, selective, and orally bioavailable igf-1r inhibitor with robust in vivo efficacy in an igf-driven mouse xenograft model. [1, 2].

target

glucagon receptor

References

[1] yusheng xiong, jian guo, mari r. candelore, rui liang, corey miller, qing dallas-yang, guoqiang jiang, peggy e. mccann, sajjad a. qureshi, xinchun tong, shiyao sherrie xu, jackie shang, stella h. vincent, laurie m. tota, michael j. wright, xiaodong yang, bei b. zhang, james r. tata, and emma r. parmee. discovery of a novel glucagon receptor antagonist n-[(4-{(1s)-1-[3-(3,5-dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)-1h-pyrazol-1-yl]ethyl}phenyl)carbonyl]-β-alanine (mk-0893) for the treatment of type ii diabetes. journal of medicinal chemistry. 2012, 55: 6137-6148.
[2] meizhong jin, andrew kleinberg, andy cooke, prafulla c. gokhale, kenneth foreman, hanqing dong, kam w. siu, mark a. bittner, kristen m. mulvihill, yan yao, darla landfair, matthew o’connor, gilda mak, jonathan a. pachter, robert wild, maryland rosenfeld-franklin, qunsheng ji, mark j. mulvihill. potent and selective cyclohexyl-derived imidazopyrazine insulin-like growth factor 1 receptor inhibitors with in vivo efficacy. bioorganic & medicinal chemistry letters. 2011, 21: 1176–1180.

b-Alanine, N-[4-[(1S)-1-[3-(3,5-dichlorophenyl)-5-(6-methoxy-2-naphthalenyl)-1H-pyrazol-1-yl]ethyl]benzoyl]- Preparation Products And Raw materials

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View Lastest Price from b-Alanine, N-[4-[(1S)-1-[3-(3,5-dichlorophenyl)-5-(6-methoxy-2-naphthalenyl)-1H-pyrazol-1-yl]ethyl]benzoyl]- manufacturers

Career Henan Chemical Co

Product: MK 0893 870823-12-4
Price: US $1.00/g
Min. Order: 1g
Purity: 95-99%
Supply Ability: 1ton
Release date: 2020-01-10

870823-12-4, b-Alanine, N-[4-[(1S)-1-[3-(3,5-dichlorophenyl)-5-(6-methoxy-2-naphthalenyl)-1H-pyrazol-1-yl]ethyl]benzoyl]-Related Search:

b-Alanine, N-[4-[(1S)-1-[3-(3,5-dichlorophenyl)-5-(6-methoxy-2-naphthalenyl)-1H-pyrazol-1-yl]ethyl]benzoyl]-

Merk Glucagon antagonist

MK0893;MK 0893

N-[4-[(1S)-1-[3-(3,5-Dichlorophenyl)-5-(6-methoxy-2-naphthalenyl)-1H-pyrazol-1-yl]ethyl]benzoyl]-beta-alanine

(S)-3-(4-(1-(3-(3,5-Dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)-1H-pyrazol-1-yl)ethyl)benzami

Merck Glucagon Receptor Antagonist

MK 0893

(S)-3-(4-(1-(3-(3,5-Dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)-1H-pyrazol-1-yl)ethyl)benzamido)

β-Alanine, N-[4-[(1S)-1-[3-(3,5-dichlorophenyl)-5-(6-methoxy-2-naphthalenyl)-1H-pyrazol-1-yl]ethyl]benzoyl]-

870823-12-4