5-Bromo-1H-indazole-3-carbonitrile
- Product Name
- 5-Bromo-1H-indazole-3-carbonitrile
- CAS No.
- 201227-39-6
- Chemical Name
- 5-Bromo-1H-indazole-3-carbonitrile
- Synonyms
- 5-BROMO-3-CYANOINDAZOLE;5-Bromo-3-cyano-1H-indazole;5-Bromo-indazole-3-carbonitrile;3-Methyl-1H-indazole hydrochloride;5-BROMO-1H-INDAZOLE-3-CARBONITRILE;1H-INDAZOLE-3-CARBONITRILE, 5-BROMO-;5-BROMO-1H-INDAZOLE-3-CARBOXYNITRILE;5-Bromo-1H-indazole-3-carbonitrile 95+%
- CBNumber
- CB9190317
- Molecular Formula
- C8H4BrN3
- Formula Weight
- 222.04
- MOL File
- 201227-39-6.mol
5-Bromo-1H-indazole-3-carbonitrile Property
- Boiling point:
- 425.3±25.0 °C(Predicted)
- Density
- 1.85±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 9.61±0.40(Predicted)
- Appearance
- Off-white to yellow Solid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M782780
- Product name
- 3-methyl-2H-indazole
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 265735
- Product name
- 5-Bromo-1H-indazole-3-carbonitrile
- Packaging
- 100mg
- Price
- $379
- Updated
- 2021/12/16
- Product number
- FB51079
- Product name
- 5-Bromo-1H-indazole-3-carbonitrile
- Packaging
- 1g
- Price
- $450
- Updated
- 2021/12/16
- Product number
- FB51079
- Product name
- 5-Bromo-1H-indazole-3-carbonitrile
- Packaging
- 500mg
- Price
- $300
- Updated
- 2021/12/16
- Product number
- 3H37-9-X8
- Product name
- 5-Bromo-1H-indazole-3-carbonitrile
- Packaging
- 250mg
- Price
- $85
- Updated
- 2021/12/16
5-Bromo-1H-indazole-3-carbonitrile Chemical Properties,Usage,Production
Uses
5-Bromo-1H-indazole-3-carbonitrile is an organic compound that is often used as an intermediate in the synthesis of pharmaceuticals and bioactive molecules.
Synthesis
882855-95-0
201227-39-6
The general procedure for the synthesis of 5-bromo-1H-indazole-3-carbonitrile from 2-(2-amino-5-bromophenyl)acetonitrile is as follows: to a cooled solution of 2-(2-amino-5-bromophenyl)acetonitrile (11 g, 52 mmol) in concentrated hydrochloric acid (110 mL) was slowly added a solution of sodium nitrite (3.9 g, 57 mmol) in water (20 mL) at -50 °C. . After addition, the reaction mixture was stirred continuously at -50°C for 2 hours. Subsequently, the temperature of the mixture was raised to 0 °C, neutralized with 33% ammonium hydroxide solution and extracted with ethyl acetate (3 x 100 mL). The organic phases were combined, washed with saturated sodium chloride solution (100 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure. The resulting crude product was purified by column chromatography (100-200 mesh silica gel) with the eluent being a petroleum ether solution of 10% ethyl acetate. The eluate was collected to give the target product 5-bromo-3-cyanoindazole (7 g, 60% yield) as a solid. Its 1HNMR (CDCl3) data were as follows: δ 10.7 (br, 1H), 8.1 (s, 1H), 7.64 (d, 1H), 7.5 (d, 1H).
References
[1] Journal of Medicinal Chemistry, 2015, vol. 58, # 8, p. 3611 - 3625
[2] Patent: US2011/111046, 2011, A1. Location in patent: Page/Page column 17
[3] Patent: WO2011/58473, 2011, A1. Location in patent: Page/Page column 35; 36
5-Bromo-1H-indazole-3-carbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Bromo-1H-indazole-3-carbonitrile manufacturers
- Product
- 5-Bromo-1H-indazole-3-carbonitrile 201227-39-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-08