ChemicalBook > CAS DataBase List > 3,4-DIFLUORO-2-HYDROXYBENZOIC ACID
3,4-DIFLUORO-2-HYDROXYBENZOIC ACID
- Product Name
- 3,4-DIFLUORO-2-HYDROXYBENZOIC ACID
- CAS No.
- 189283-51-0
- Chemical Name
- 3,4-DIFLUORO-2-HYDROXYBENZOIC ACID
- Synonyms
- 3,4-DIFLUOROSALICYLIC ACID;3,4-Dilfuoro-2-hydroxybenzoiacid;3,4-DIFLUORO-2-HYDROXYBENZOIC ACID;3,4-Difluoro-2-hydroxybenzoicacid98%;3,4-Difluoro-2-hydroxybenzoicacid99%;Benzoic acid, 3,4-difluoro-2-hydroxy-;3,4-Difluoro-2-hydroxybenzoic acid 99%
- CBNumber
- CB9190599
- Molecular Formula
- C7H4F2O3
- Formula Weight
- 174.1
- MOL File
- 189283-51-0.mol
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3,4-DIFLUORO-2-HYDROXYBENZOIC ACID Property
- Melting point:
- 177-179°C
- Boiling point:
- 282℃
- Density
- 1.600
- Flash point:
- 124℃
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 2.32±0.13(Predicted)
- Appearance
- Off-white to light yellow Solid
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
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N-Bromosuccinimide Price
TRC
- Product number
- D452075
- Product name
- 3,4-Difluoro-2-hydroxybenzoicAcid
- Packaging
- 25mg
- Price
- $45
- Updated
- 2021/12/16
TRC
- Product number
- D452075
- Product name
- 3,4-Difluoro-2-hydroxybenzoicAcid
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
Apolloscientific
- Product number
- PC7835
- Product name
- 3,4-Difluoro-2-hydroxybenzoicacid
- Purity
- 98%
- Packaging
- 1g
- Price
- $60
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 2629-3-Y7
- Product name
- 3,4-Difluoro-2-hydroxybenzoic acid
- Purity
- 99%
- Packaging
- 250mg
- Price
- $45
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 2629-3-Y7
- Product name
- 3,4-Difluoro-2-hydroxybenzoic acid
- Purity
- 99%
- Packaging
- 1g
- Price
- $90
- Updated
- 2021/12/16
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3,4-DIFLUORO-2-HYDROXYBENZOIC ACID Chemical Properties,Usage,Production
Synthesis
61079-72-9
189283-51-0
The general procedure for the synthesis of 3,4-difluoro-2-hydroxybenzoic acid from 2,3,4-trifluorobenzoic acid was carried out as follows: solid sodium hydroxide (4.52 g, 113 mmol) was added batchwise to a solution of dimethylimidazolidinone (10 mL) of 2,3,4-trifluorobenzoic acid (5.0 g, 28 mmol) under the conditions of cooling in an ice bath and stirring. Subsequently, the reaction mixture was heated to 120 °C and maintained at this temperature for 2 h. During this time, the progress of the reaction was monitored by TLC to confirm the complete consumption of 2,3,4-trifluorobenzoic acid. Upon completion of the reaction, the mixture was cooled to room temperature and acidified to pH 5-6 with 2N hydrochloric acid (7.5 mL).The precipitated white solid was collected by filtration, washed with excess water, and dried to afford the target product, 3,4-difluoro-2-hydroxybenzoic acid (3.6 g, 73.4% yield), with a melting point of 174-177 °C. The product structure was determined by 1H-NMR. The structure of the product was confirmed by 1H-NMR (400 MHz, DMSO-d6) and IR (KBr) spectroscopy: 1H-NMR δ 6.94-7.01 (m, 1H, aryl), 7.64-7.68 (m, 1H, aryl); IR 3208.9 cm-1 (OH), 1654.1 cm-1 (C=O), 1625.7 cm-1 (C =C, aromatic), 1315.2 cm-1 (C-O).
References
[1] Journal of Fluorine Chemistry, 2003, vol. 121, # 1, p. 97 - 99
[2] Medicinal Chemistry Research, 2015, vol. 24, # 9, p. 3516 - 3528
[3] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 10, p. 2455 - 2458
3,4-DIFLUORO-2-HYDROXYBENZOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3,4-DIFLUORO-2-HYDROXYBENZOIC ACID manufacturers
Career Henan Chemical Co
- Product
- 3,4-DIFLUORO-2-HYDROXYBENZOIC ACID 189283-51-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-26
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