OXCARBAZEPINE-D4
- Product Name
- OXCARBAZEPINE-D4
- CAS No.
- 1134188-71-8
- Chemical Name
- OXCARBAZEPINE-D4
- Synonyms
- TRILEPTAL-D4;OXCARBAZEPINE-D4;D4-Oxcarbazepine;10,11-DIHYDRO-10-OXO-5H-DIBENZ[B,F]AZEPINE-5-CARBOXAMIDE-D4;10,11-dihydro-11-oxo-5H-dibenz[b,f]azepine-1,2,3,4-d4-5-carboxamide;1,2,3,4-tetradeuterio-5-oxo-6H-benzo[b][1]benzazepine-11-carboxamide;9-oxo(4,5,6,7-2H?)-2-azatricyclo[9.4.0.03,?]pentadeca-1(11),3(8),4,6,12,14-hexaene-2-carboxamide
- CBNumber
- CB9198126
- Molecular Formula
- C15H8D4N2O2
- Formula Weight
- 256.29
- MOL File
- Mol file
OXCARBAZEPINE-D4 Property
- storage temp.
- Store at -20°C
- solubility
- DMSO: soluble
- form
- A solid
N-Bromosuccinimide Price
- Product number
- 29995
- Product name
- Oxcarbazepine-d4
- Packaging
- 1mg
- Price
- $238
- Updated
- 2024/03/01
- Product number
- 4558DC
- Product name
- 1,2,3,4-Tetradeuterio-5-oxo-6H-benzo[b][1]benzazepine-11-carboxamide
- Packaging
- 1mg
- Price
- $363
- Updated
- 2021/12/16
OXCARBAZEPINE-D4 Chemical Properties,Usage,Production
Description
Oxcarbazepine-d4 is intended for use as an internal standard for the quantification of oxcarbazepine by GC- or LC-MS. Oxcarbazepine is a prodrug form of the antiepileptic compound 10,11-dihydro-10-hydroxy carbamazepine . It inhibits high-frequency repetitive firing of rat spinal cord neurons when used at a concentration of 1 μM. Oxcarbazepine protects against electroshock-induced tonic hindlimb extension (ED50s = 10-20 mg/kg), as well as seizures induced by pentylenetetrazole (PTZ; ) or picrotoxin in rodents (ED50s = 23-30 and 150-250 mg/kg, respectively). Formulations containing oxcarbazepine have been used in the treatment of epileptic seizures.
Uses
Oxcarbazepine-d4-1 is deuterium labeled Oxcarbazepine. Oxcarbazepine is a sodium channel blocker[1]. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines[2]. Anti-cancer and anticonvulsant effects[2][3].
References
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Ashley M Thomas, et al. Old Friends With New Faces: Are Sodium Channel Blockers the Future of Adjunct Pain Medication Management?J Pain. 2018 Jan;19(1):1-9. DOI:10.1016/j.jpain.2017.08.001
[3] Ching-Yi Lee,et al. The effects of antiepileptic drugs on the growth of glioblastoma cell lines. J Neurooncol. 2016 May;127(3):445-53. DOI:10.1007/s11060-016-2056-6
[4] M Schmutz, et al. Oxcarbazepine: preclinical anticonvulsant profile and putative mechanisms of action. Epilepsia. 1994;35 Suppl 5:S47-50. DOI:10.1111/j.1528-1157.1994.tb05967.x
OXCARBAZEPINE-D4 Preparation Products And Raw materials
Raw materials
Preparation Products
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