Mahanimbine
- Product Name
- Mahanimbine
- CAS No.
- 21104-28-9
- Chemical Name
- Mahanimbine
- Synonyms
- Mahanimbin;Mahanimbine;Mahanimbine-RM;(+)-Mahanimbine;(+)-3,11-Dihydro-3,5-dimethyl-3-(4-methyl-3-penten-1-yl)pyrano[3,2-a]carbazole;Pyrano[3,2-a]carbazole, 3,11-dihydro-3,5-dimethyl-3-(4-methyl-3-penten-1-yl)-, (3S)-
- CBNumber
- CB92056338
- Molecular Formula
- C23H25NO
- Formula Weight
- 331.45
- MOL File
- 21104-28-9.mol
Mahanimbine Property
- Melting point:
- 94-95 °C
- Boiling point:
- 502.6±39.0 °C(Predicted)
- Density
- 1.109
- solubility
- DMSO: 10 mM
- pka
- 17.31±0.40(Predicted)
- Stability:
- Light Sensitive
- InChI
- InChI=1S/C23H25NO/c1-15(2)8-7-12-23(4)13-11-18-21-19(14-16(3)22(18)25-23)17-9-5-6-10-20(17)24-21/h5-6,8-11,13-14,24H,7,12H2,1-4H3/t23-/m0/s1
- InChIKey
- HTNVFUBCWIYPJN-QHCPKHFHSA-N
- SMILES
- N1C2=C(C=CC=C2)C2=C1C1C=C[C@](C)(CC/C=C(\C)/C)OC=1C(C)=C2
Safety
- Risk Statements
- 53
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
H413May cause long lasting harmful effects to aquatic life
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 77875
- Product name
- Mahanimbine
- Purity
- analytical standard
- Packaging
- 10mg
- Price
- $968
- Updated
- 2022/05/15
- Product number
- FD137460
- Product name
- (+)-3,11-Dihydro-3,5-dimethyl-3-(4-methyl-3-penten-1-yl)pyrano[3,2-a]carbazole
- Packaging
- 5mg
- Price
- $600
- Updated
- 2021/12/16
- Product number
- FD137460
- Product name
- (+)-3,11-Dihydro-3,5-dimethyl-3-(4-methyl-3-penten-1-yl)pyrano[3,2-a]carbazole
- Packaging
- 10mg
- Price
- $930
- Updated
- 2021/12/16
- Product number
- 1429CB
- Product name
- Mahanimbine
- Packaging
- 2mg
- Price
- $185
- Updated
- 2021/12/16
- Product number
- FD137460
- Product name
- (+)-3,11-Dihydro-3,5-dimethyl-3-(4-methyl-3-penten-1-yl)pyrano[3,2-a]carbazole
- Packaging
- 1mg
- Price
- $250
- Updated
- 2021/12/16
Mahanimbine Chemical Properties,Usage,Production
Description
The leaves of Murraya koenigii Spreng. also furnish this crystalline alkaloid which is dextrorotatory with [α]D + 52° (CHCI3). The ultraviolet spectrum exhibits several absorption maxima occurring at 227, 288,300,315,328,343 and 357 mil. It furnishes a crystalline picrate as pale yellow needles, m.p. 142°C and on catalytic reduction gives the dihydro derivative, m.p. 101°C and finally the tetrahydro compound, m.p. 108°C. Spectroscopic and chemical data support the structure given above.
Uses
Mahanimbine is an orally active alkaloid from Murraya koenigii. Mahanimbine inhibits progression of high-fat diet (HFD)-induced metabolic complications in mice[1].
Definition
ChEBI: Mahanimbine is a member of carbazoles.
in vivo
Mahanimbine (2-4 mg/kg; p.o.; daily for 12 weeks) prevents HFD-induced weight gain in mice (male and female)[1].
Mahanimbine prevented HFD-induced hyperlipidemia and fat accumulation in adipose tissue and liver along with the restricted progression of systemic inflammation and oxidative stress[1].
Mahanimbine treatment improves glucose clearance and upregulates the expression of insulin responsive genes in liver and adipose tissue[1].
| Animal Model: | Swiss albino mice (7-8 weeks old, both sex)[1] |
| Dosage: | HFD+LD (2 mg/kg of body weight of mahanimbine), HFD+HD (4 mg/kg of body weight of mahanimbine); |
| Administration: | Oral suspension; daily for 12 weeks |
| Result: | Male HFD+LD and HFD+HD groups showed 51.70±6 3.59% and 47.37±3.73% weight gain, respectively, as compared with 71.02±6 6.04% in HFD fed mice whereas female HFD+LD and HFD+HD groups showed 24.31±1.68% and 25.10±2.61% weight gain as compared with HFD group with 36.69±3.60% of weight gain. |
References
Chakraborty, Das, Bose., Sci. Cult. (Calcutta), 32, 83 (1966) Structure: Narasimhan, Paradkar, Chitguppi., Tetrahedron Lett., 5501 (1968)
Mahanimbine Preparation Products And Raw materials
Raw materials
Preparation Products
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