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Sapropterin Hydrochloride

Product Name
Sapropterin Hydrochloride
CAS No.
69056-38-8
Chemical Name
Sapropterin Hydrochloride
Synonyms
Sapropterin Dihydrochloride;Sapropterin HCl;Sapropterin DiHCl;Kuvan;Tetrahydro-L-Biopterin (hydrochloride);(6R)-5,6,7,8-TETRAHYDRO-L-BIOPTERIN DIHYDROCHLORIDE;6R-BH4;sun0588;Biopten;THB, 2HCL
CBNumber
CB9206285
Molecular Formula
C9H17Cl2N5O3
Formula Weight
314.17
MOL File
69056-38-8.mol
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Sapropterin Hydrochloride Property

Melting point:
245-246° (dec)
alpha 
D25 -6.81° (c = 0.665 in 0.1 M HCl)
storage temp. 
-20°C
solubility 
water, oxygen free: soluble19.60 - 20.40mg/mL, clear to slightly hazy, colorless to faintly yellow
form 
White to off-white powder.
color 
White to off-white
Stability:
Hygroscopic
CAS DataBase Reference
69056-38-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
RTECS 
UO3516500
Toxicity
LD50 oral in rat: 1gm/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T4425
Product name
(6R)-5,6,7,8-Tetrahydrobiopterin dihydrochloride
Packaging
5mg
Price
$84.1
Updated
2024/03/01
Sigma-Aldrich
Product number
T4425
Product name
(6R)-5,6,7,8-Tetrahydrobiopterin dihydrochloride
Packaging
25mg
Price
$277
Updated
2024/03/01
Cayman Chemical
Product number
81880
Product name
tetrahydro-L-Biopterin (hydrochloride)
Purity
≥99%
Packaging
5mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
81880
Product name
tetrahydro-L-Biopterin (hydrochloride)
Purity
≥99%
Packaging
10mg
Price
$65
Updated
2024/03/01
Sigma-Aldrich
Product number
T4425
Product name
(6R)-5,6,7,8-Tetrahydrobiopterin dihydrochloride
Packaging
100mg
Price
$920
Updated
2024/03/01
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Sapropterin Hydrochloride Chemical Properties,Usage,Production

Description

Sapropterin hydrochloride is a monoamine biosynthesis enhancer introduced for the treatment of hyperphenylalaninemia.Animal studies indicate that sapropterin hydrochloride increases brain levels of serotonin and enhances the release of acetylcholine from nerve terminals. The compound is also being investigated as a potential cognitive enhancer.

Description

(6R)-5,6,7,8-tetrahydro-L-Biopterin (hydrochloride) (BH4) is a cofactor that, in the presence of enzyme site iron, binds to phenylalanine hydroxylase, tryptophan or tyrosine hydroxylase, and nitric oxide synthase (NOS), to facilitate the production of aromatic amino acids, neurotransmitters, and nitric oxide (NO), respectively. It is formed de novo from GTP with GTP cyclohydrolase-1 (GCH1) catalyzing the rate limiting conversion of GTP to 7,8-dihydroneopterin (NH2TP) followed by subsequent processing by TS and SPR to convert NH2TP to BH4. BH4 acts as a radical-trapping antioxidant that inhibits phospholipid oxidation in lipid membranes. It inhibits IKE- or RSL3-induced ferroptosis in HT-1080 cells (EC50s = 21 and 69 μM), as well as ferroptosis induced by knockout of glutathione peroxidase (Gpx4-/-) in immortalized mouse fibroblasts. BH4 also reduces RLS3-induced lipid peroxidation in murine fibroblasts and HT-1080 cells when used at a concentration of 50 μM.

Chemical Properties

White Crystalline Solid

Originator

Suntory (Japan)

Uses

Tetrahydrobiopterin is a naturally occurring essential cofactor of the three aromatic amino acid hydroxylase enzymes, used in the degradation of amino acid phenylalanine and in the biosynthesis of the neurotransmitters serotonin, melatonin, dopamine, norepinephrine , epinephrine, and is a cofactor for the production of nitric oxide by the nitric oxide synthases. Chemically, its structure is that of a reduced pteridine derivative.

Uses

A natural cofactor for phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, and nitric oxide synthase. An essential cofactor for the production of neurotransmitters such as catecholamines, serotonin, and nitric oxide. Increasing

Definition

ChEBI: The dihydrochloride salt of sapropterin. It is used for the diagnosis and treatment of variant forms of phenylketonuria (hyperphenylalaninaemia) associated with tetrahydrobiopterin deficiency. Natural cofactor for phenylalanine hydroxylase, tyrosine hydrox lase, tryptophan hydroxylase, and nitric oxide synthetase.

brand name

Biopten

General Description

Tetrahydrobiopterin is a natural cofactor for phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, nitric oxide synthase and alkylglycerol monooxygenase.

Biochem/physiol Actions

Lack of tetrahydrobiopterin may cause hyperphenylalaninemia. Diseases like, Parkinson′s, autism, depression and Alzheimer′s shows low concentration of tetrahydrobiopterin in the cerebrospinal fluid. This coenzyme participates in dopamine (DA) synthesis.

Purification Methods

Recrystallisation of BH4.2HCl from HCl enriches BH4 in the natural 6R isomer. Dissolve the salt (~6g) in conc HCl (15mL) under gentle warming, then add EtOH (30mL) dropwise, chill and collect the colourless needles (67%, up to 99% if the mother liquors are concentrated), and dry it in vacuo immediately over P2O5 and KOH. It is stable indefinitely at -20o in a dry atmosphere. Better store it in sealed ampoules under dry N2. It can be recrystallised from 6N aqueous HCl. It has UV max (in 2N HCl) at 264nm ( 16,770; pH 3.5 phosphate buffer) 265nm ( 13,900); (in pH 7.6) at 297nm ( 9,500) and 260nm sh ( 4,690). It has been separated from the 6S-isomer by HPLC on a Partisil-10SCX column using 30mM ammonium phosphate buffer (pH 3.0) containing 3mM NaHSO3 (2mL/minute flow rate; 275nm detector) with retention times of 5.87minutes (6R) and 8.45minutes (6S). It is stable in acidic solutions and can be stored for extended periods at -20o in 0.04M HCl. Above pH 7 the neutral species are obtained, and these are readily oxidised by the oxygen in the solvent to the quinonoid species, and then further oxidation and degradation occurs at room temperature. These changes are slower at 0o. The sulfate salt can be obtained by recrystallisation from 2M H2SO4 and is less soluble in water than the hydrochloride salt. The 6R-2,5,1',2'-tetraacetylbiopterin derivative has m 292o(dec) after recrystallisation from MeOH (100 parts) and [] 20 -144o (c 0.5, CHCl3), [] 589 +12.8o (c 0.39, Me2SO). [NMR, UV: Matsuura et al. Heterocycles 23 3115 1985, Viscontini et al. Helv Chim Acta 62 2577 1979, Armarego et al. Aust J Chem 37 355 1984, Beilstein 26 III/IV 4032.]

Sapropterin Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Sapropterin Hydrochloride Suppliers

Canada 1 China 144 Germany 2 India 11 Japan 2 Switzerland 3 United Kingdom 6 United States 30 Global 199
Prasol Chemicals Private Limited
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Disto Pharmaceuticals Pvt Ltd
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Pharmaffiliates Analytics and Synthetics P. Ltd
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SynZeal Research Pvt Ltd
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A.J Chemicals
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HONOUR LAB LTD
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SOLARA ACTIVE PHARMA SCIENCES LTD
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View Lastest Price from Sapropterin Hydrochloride manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
Sapropterin Hydrochloride 69056-38-8
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2021-03-31
Hebei Mojin Biotechnology Co., Ltd
Product
Sapropterin Hydrochloride 69056-38-8
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-09-05
Handan Tongyi New Material Technology Co., Ltd
Product
Sapropterin Hydrochloride 69056-38-8
Price
US $20.00/Kg
Min. Order
1KG
Purity
99.99%
Supply Ability
500kg/month
Release date
2021-02-25

69056-38-8, Sapropterin HydrochlorideRelated Search:

Tetrahydrofurfuryl alcohol Tetrahydropyran (6R)-5,6,7,8-TETRAHYDRO-L-BIOPTERIN DIHYDROCHLORIDE,(6R,S)-5,6,7,8-TETRAHYDRO-L-BIOPTERIN DIHYDROCHLORIDE TETRAHYDRO-L-BIOPTERIN, DIHYDROCHLORIDE,6-BETA-5,6,7,8-TETRAHYDRO-L-BIOPTERIN DIHYDROCHLORIDE,(6R)-5,6,7,8-TETRAHYDRO-L-BIOPTERIN DIHYDROCHLORIDE 4-AMINO-(6R)-5,6,7,8-TETRAHYDRO-L-BIOPTERIN DIHYDROCHLORIDE

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  • (6b)-5,6,7,8-Tetrahydro-L-biopterin dihydrochloride
  • 4(1H)-Pteridinone, 2-amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-, dihydrochloride, [6R-[6R*(1R*,2S*)]]-
  • 4(1H)-Pteridinone, 2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-, dihydrochloride, (6R)- (9CI)
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  • (R)-2-Amino-6-((1R,2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydropteridin-4(1H)-one dihydrochloride
  • (6R)-5,6,7,8-tetrahydro-L-Biopterin (hydrochloride)
  • (R)-2-amino-6-((1R,2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydropteridin-4(1H)-one hydrochloride
  • (6R)-2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-3H-pteridin-4-one
  • 69056-38-8
  • C9H17Cl2N5O3
  • C9H15N5O32HCl
  • C9H15N5O32ClH
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