2,4,7-TRINITRO-9-FLUORENONE
- Product Name
- 2,4,7-TRINITRO-9-FLUORENONE
- CAS No.
- 129-79-3
- Chemical Name
- 2,4,7-TRINITRO-9-FLUORENONE
- Synonyms
- TNF;mTNF-α;tnf(ketone);TRINITROFLUORENONE;LABOTEST-BB LT00645370;2,4,7-trinitrofluorone;2,4,7-Trinirofluorenone;2,4,7-TRINITROFLUORENONE;2，4，7-Trinitrofluoren-9-one;2,4,7-trinitro-fluoren-9-on
- CBNumber
- CB9210251
- Molecular Formula
- C13H5N3O7
- Formula Weight
- 315.19
- MOL File
- 129-79-3.mol
2,4,7-TRINITRO-9-FLUORENONE Property
- Melting point:
- 176-178°C
- Boiling point:
- 454.77°C (rough estimate)
- Density
- 1.5148 (rough estimate)
- refractive index
- 1.5600 (estimate)
- storage temp.
- -20°C
- form
- powder
- color
- white
- CAS DataBase Reference
- 129-79-3(CAS DataBase Reference)
- EPA Substance Registry System
- 2,4,7-Trinitrofluoren-9-one (129-79-3)
Safety
- Risk Statements
- 23/24/25-33
- Safety Statements
- 9-16-36/37/39
- RIDADR
- 387
- WGK Germany
- 3
- HazardClass
- 1.1D
- PackingGroup
- II
- Hazardous Substances Data
- 129-79-3(Hazardous Substances Data)
- Toxicity
- LD50 oral in rat: 9910mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- T7539
- Product name
- Tumor Necrosis Factor-α from mouse
- Purity
- TNF-α, recombinant, expressed in E. coli, powder, suitable for cell culture
- Packaging
- 10μg
- Price
- $278
- Updated
- 2024/03/01
- Product number
- T7539
- Product name
- Tumor Necrosis Factor-α from mouse
- Purity
- TNF-α, recombinant, expressed in E. coli, powder, suitable for cell culture
- Packaging
- 50μg
- Price
- $779
- Updated
- 2024/03/01
- Product number
- T5944
- Product name
- Tumor Necrosis Factor-α from rat
- Purity
- TNF-α, recombinant, expressed in E. coli, powder, suitable for cell culture
- Packaging
- 50μG
- Price
- $329.6
- Updated
- 2024/03/01
- Product number
- T5944
- Product name
- Tumor Necrosis Factor-α from rat
- Purity
- TNF-α, recombinant, expressed in E. coli, powder, suitable for cell culture
- Packaging
- 10μG
- Price
- $335
- Updated
- 2024/03/01
- Product number
- SAB4502982
- Product name
- Anti-TNFA antibody produced in rabbit
- Purity
- affinity isolated antibody
- Packaging
- 100μG
- Price
- $485
- Updated
- 2023/06/20
2,4,7-TRINITRO-9-FLUORENONE Chemical Properties,Usage,Production
Uses
Tumor Necrosis Factor-α from mouse, a potent proinflammatory cytokine has been used:
- to activate MS1 endothelium cells
- to induce lipolysis in adipocytes
- to study its effect on liganded and unliganded glucocorticoid receptor (GR) in interleukin (IL)-6 and IL-8 gene regulation
Uses
TNF-α influences the growth and function of both normal and neoplastic cells. TNF-α causes cytolysis or cytostasis of certain transformed cells being synergistic with γ-interferon in its cytotoxicity.
General Description
Pale yellow needles (from acetic acid or benzene) or yellow powder.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
Literature sources indicate that 2,4,7-TRINITRO-9-FLUORENONE is flammable. . Aromatic nitrates range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction.
Hazard
Suspected carcinogen. Mildly toxic by ingestion. A skin and eye irritant.
Fire Hazard
Literature sources indicate that 2,4,7-TRINITRO-9-FLUORENONE is flammable.
Biochem/physiol Actions
The TNFA (tumor necrosis factor α) gene is significantly associated with the regulation of innate and adaptive immune responses. Polymorphism of TNFA gene is known to cause acute motor axonal neuropathy. The cytokine release and gene action is associated with epithelial cells, myeloid cells, endothelial, as well as tumor cells. Tumor cells are known to release TNFA, specifically in response to chemotherapy
Safety Profile
Suspected carcinogen with experimental tumorigenic data. Mildly toxic by ingestion. Human mutation data reported. A skin and eye irritant. When heated to decomposition it emits hghly toxic fumes of NOx. See also NITRO COMPOUNDS of AROMATIC HYDROCARBONS and KETONES.
Purification Methods
Crystallise it from nitric acid/water (3:1), wash it with water and dry it under vacuum over P2O5, or recrystallise it from dry *benzene. [Beilstein 7 II 410, 7 III 2348, 7 IV 1638.]