ChemicalBook > CAS DataBase List > 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, ethyl ester

1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, ethyl ester

Uses

Product Name: 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, ethyl ester
CAS No.: 221675-35-0
Chemical Name: 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, ethyl ester
Synonyms: ethyl 1H-pyrrolo[2;Ethyl 7-azaindole-2-carboxylate;ethyl1H-pyrrolo[2,3-b]pyridine-2-carbo;2-(Ethoxycarbonyl)-1H-pyrrolo[2,3-b]pyridine;Ethyl 1H-pyrrolo[2,3-b]pyridine-2-carboxylate;ethyl 1H-pyrrolo[2,3-b]pyridine-2-carbo×ylate;ethyl lH-pyrrolo[2,3- b]pyridine-2-carboxylate;1H-Prrolo[2,3-b]pyridine-2-carboxylic acid ethyl ester;1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, ethyl ester;1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, ethyl ester (9CI, ACI)
CBNumber: CB92129692
Molecular Formula: C10H10N2O2
Formula Weight: 190.2
MOL File: 221675-35-0.mol

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1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, ethyl ester Property

Boiling point:: 436.4±37.0 °C(Predicted)
Density: 1.27±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 5.73±0.40(Predicted)
Appearance: Off-white to yellow Solid
InChI: InChI=1S/C10H10N2O2/c1-2-14-10(13)8-6-7-4-3-5-11-9(7)12-8/h3-6H,2H2,1H3,(H,11,12)
InChIKey: CBIVEMGUNRNUEB-UHFFFAOYSA-N
SMILES: C12NC(C(OCC)=O)=CC1=CC=CN=2

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: E940190
Product name: Ethyl1H-Pyrrolo[2,3-B]pyridine-2-carboxylate
Packaging: 10mg
Price: $45
Updated: 2021/12/16

TRC

Product number: E940190
Product name: Ethyl1H-Pyrrolo[2,3-B]pyridine-2-carboxylate
Packaging: 100mg
Price: $155
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H23-1-Y7
Product name: Ethyl 7-azaindole-2-carboxylate
Packaging: 100mg
Price: $45
Updated: 2021/12/16

ChemScene

Product number: CS-B1286
Product name: 1H-Pyrrolo[2,3-b]pyridine-2-carboxylicacid,ethylester
Purity: 99.91%
Packaging: 250mg
Price: $50
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H23-1-Y7
Product name: Ethyl 7-azaindole-2-carboxylate
Packaging: 250mg
Price: $96
Updated: 2021/12/16

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1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, ethyl ester Chemical Properties,Usage,Production

Uses

1H-pyrrolo[2,3-B]pyridine-2-carboxylic acid ethyl ester is an important raw material in organic synthesis. Its derivative, pyrrolopyridine-2-carboxamide, is a glycogen phosphorylase inhibitor used to prevent or treat diabetes, hypertension, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, atherosclerosis, or tissue ischemia, and can also be used as a cardioprotective agent.

Synthesis

287384-79-6

221675-35-0

General procedure for the synthesis of ethyl 1H-pyrrolo[2,3-B]pyridine-2-carboxylate from compound (CAS: 287384-79-6): compound 29 (9.7 g, 31.4 mmol, 1 equiv.) was dissolved in 6 N hydrochloric acid solution (50 mL) and stirred for 2 hr at 50 °C, followed by continued stirring at room temperature overnight. Upon completion of the reaction, the pH of the reaction mixture was adjusted to 13 with solid potassium carbonate (K2CO3), followed by extraction with ethyl acetate (EtOAc). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford the target product 30 (6.0 g, 100% yield). The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 11.12 (br s, 1H), 8.59 (d, J = 4.8 Hz, 1H), 8.05 (dd, J = 8.0, 1.6 Hz, 1H), 7.19 (s, 1H), 7.18-7.15 (m, 1H), 4.46 (q, J = 6.8 Hz. 2H), 1.44 (t, J = 6.8 Hz, 3H).

References

[1] European Journal of Medicinal Chemistry, 2014, vol. 88, p. 3 - 9
[2] Patent: WO2015/187428, 2015, A1. Location in patent: Paragraph 00502; 00505; 00506
[3] Patent: US2009/318455, 2009, A1. Location in patent: Page/Page column 69; 93

1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, ethyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, ethyl ester manufacturers

Huida Pharmaceutical Technology (Shanghai) Co., Ltd.

Product: 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, ethyl ester 221675-35-0
Price: US $0.00-0.00/kg
Min. Order: 0.1kg
Purity: 98%
Supply Ability: 100kg
Release date: 2023-03-07

Career Henan Chemical Co

Product: 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, ethyl ester 221675-35-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%-99.9%
Supply Ability: 200kg
Release date: 2020-03-05

221675-35-0, 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, ethyl esterRelated Search:

Vitamin B series Pyrrole Pyridine 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, ethyl ester 1H-PYRROLO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID ETHYL 4-METHOXY-1H-PYRROLO[2,3-B]PYRIDINE-2-CARBOXYLATE 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, methyl ester ETHYL 6-CHLORO-7-AZAINDOLE-2-CARBOXYLATE

1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, ethyl ester

Ethyl 7-azaindole-2-carboxylate

1H-Prrolo[2,3-b]pyridine-2-carboxylic acid ethyl ester

2-(Ethoxycarbonyl)-1H-pyrrolo[2,3-b]pyridine

ethyl 1H-pyrrolo[2,3-b]pyridine-2-carbo×ylate

ethyl 1H-pyrrolo[2

ethyl1H-pyrrolo[2,3-b]pyridine-2-carbo

2-(Ethoxycarbonyl)-1H-pyrrolo[2,3-b]pyridine, Ethyl 1H-pyrrolo[2,3-b]pyridine-2-carboxylate

ethyl lH-pyrrolo[2,3- b]pyridine-2-carboxylate

1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, ethyl ester (9CI, ACI)

Ethyl 1H-pyrrolo[2,3-b]pyridine-2-carboxylate

221675-35-0

Heterocycle-Pyridine series