Ethyl trans-4-Hydroxycyclohexanecarboxylate

Product Name: Ethyl trans-4-Hydroxycyclohexanecarboxylate
CAS No.: 3618-04-0
Chemical Name: Ethyl trans-4-Hydroxycyclohexanecarboxylate
Synonyms: 3618-04-0, 75877-66-6, 17159-80-7;3618-04-0, 17159-80-7, 75877-66-6;trans-Ethyl 4-hydroxycyclohexanecarboxylate;Ethyl trans-4-Hydroxycyclohexanecarboxylate;Ethyltrans-4-Hydroxycyclohexanecarboxylate>(1R,4R)-ethyl 4-hydroxycyclohexanecarboxylate;Ethyl trans-4-hydroxycyclohexane-1-carboxylate;ethyl (1r,4r)-4-hydroxycyclohexane-1-carboxylate;4-HYDROXY-CYCLOHEXANECARBOXYLIC ACID ETHYL ESTER;(Trans)-ethyl 4-hydroxycyclohexane-1-carboxylate
CBNumber: CB92130041
Molecular Formula: C9H16O3
Formula Weight: 172.22
MOL File: 3618-04-0.mol

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Ethyl trans-4-Hydroxycyclohexanecarboxylate Property

Boiling point:: 144°C/12mmHg(lit.)
Density: 1.093±0.06 g/cm3(Predicted)
refractive index: 1.4630 to 1.4670
storage temp.: Sealed in dry,Room Temperature
form: clear liquid
pka: 14.98±0.40(Predicted)
color: Colorless to Almost colorless
InChI: InChI=1S/C9H16O3/c1-2-12-9(11)7-3-5-8(10)6-4-7/h7-8,10H,2-6H2,1H3/t7-,8-
InChIKey: BZKQJSLASWRDNE-ZKCHVHJHSA-N
SMILES: [C@@H]1(C(OCC)=O)CC[C@@H](O)CC1

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Safety

HS Code: 2918199890

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: E0838
Product name: Ethyl trans-4-Hydroxycyclohexanecarboxylate
Purity: >98.0%(GC)
Packaging: 5g
Price: $232
Updated: 2025/07/31

TCI Chemical

Product number: E0838
Product name: Ethyl trans-4-Hydroxycyclohexanecarboxylate
Purity: >98.0%(GC)
Packaging: 25g
Price: $580
Updated: 2025/07/31

TRC

Product number: E945455
Product name: trans-Ethyl4-hydroxycyclohexanecarboxylate
Packaging: 500mg
Price: $50
Updated: 2021/12/16

AK Scientific

Product number: 9517AF
Product name: Ethyl trans-4-Hydroxycyclohexanecarboxylate
Packaging: 5g
Price: $134
Updated: 2021/12/16

AK Scientific

Product number: 9517AF
Product name: Ethyl trans-4-Hydroxycyclohexanecarboxylate
Packaging: 10g
Price: $214
Updated: 2021/12/16

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Ethyl trans-4-Hydroxycyclohexanecarboxylate Chemical Properties,Usage,Production

Uses

trans-Ethyl 4-hydroxycyclohexanecarboxylate acts as a reagent in the discovery of Mer kinase inhibitors for the treatment of pediatric acute lymphoblastic leukemia, in the structural activity relationship study of piperidine-based derivatives as novel influenza virus inhibitors.

Synthesis

17159-79-4

3618-04-0

To a solution of ethyl 4-oxocyclohexanecarboxylate (13.5 g, 79 mmol) in methanol (150 mL) at 0 °C was slowly added sodium borohydride (5.3 g, 140 mmol). The reaction mixture was stirred continuously for 3 hours at room temperature. Upon completion of the reaction, the reaction was quenched by the addition of water (50 mL) followed by extraction with ethyl acetate (150 mL x 1, 50 mL x 2). The organic phases were combined, washed with water (50 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent ratio: hexane-ethyl acetate 1.5:1 to 1:1) to afford ethyl trans-4-hydroxycyclohexanecarboxylate (12 g, 88% yield, cis-trans ratio = 3:7) as a colorless transparent oil.1H NMR (300 MHz, CDCl3, cis-trans mixture) δ: 4.17-4.08 (m, 2H), 3.90 ( bs, 0.3H), 3.68-3.57 (m, 0.7H), 2.42-1.28 (m, 9H), 1.27-1.22 (m, 3H) ppm.(Hydroxyl signal was not observed.)

References

[1] Journal of Medicinal Chemistry, 2016, vol. 59, # 19, p. 8967 - 9004
[2] Organic Process Research and Development, 2010, vol. 14, # 4, p. 883 - 889
[3] Patent: WO2005/80317, 2005, A2. Location in patent: Page/Page column 150
[4] Tetrahedron Letters, 2000, vol. 41, # 39, p. 7567 - 7570
[5] Patent: US5175290, 1992, A

Ethyl trans-4-Hydroxycyclohexanecarboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl trans-4-Hydroxycyclohexanecarboxylate Suppliers

Americas 1 China 85 Europe 1 India 4 Japan 1 United States 7 Global 99

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View Lastest Price from Ethyl trans-4-Hydroxycyclohexanecarboxylate manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 4-HYDROXY-CYCLOHEXANECARBOXYLIC ACID ETHYL ESTER 3618-04-0
Price: US $3.00-9.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-06-24

Shaanxi Dideu Medichem Co. Ltd

Product: 4-HYDROXY-CYCLOHEXANECARBOXYLIC ACID ETHYL ESTER 3618-04-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20t
Release date: 2024-07-12

Pharmahands (Taizhou) Co., Ltd.

Product: 4-HYDROXY-CYCLOHEXANECARBOXYLIC ACID ETHYL ESTER 3618-04-0
Price: US $0.00-0.00/KG
Min. Order: 1g
Purity: 99%
Supply Ability: 200KG/MONTH
Release date: 2020-11-12

3618-04-0, Ethyl trans-4-HydroxycyclohexanecarboxylateRelated Search:

TRANS-1,4-CYCLOHEXANE DIISOCYANATE trans-Methyl-4-aMinocyclohexanecarboxylate (R,R)-3,4-TRANS-(N-BOC)-DIAMINOPYRROLIDINE 3-Azabicyclo[3.1.0]hexane-3-carboxylicacid,6-amino-,1,1-dimethylethylester, Cyclohexanecarboxylic acid ethyl ester

4-HYDROXY-CYCLOHEXANECARBOXYLIC ACID ETHYL ESTER

Ethyl trans-4-Hydroxycyclohexanecarboxylate

ethyl (1r,4r)-4-hydroxycyclohexane-1-carboxylate

trans-4-Hydroxycyclohexanecarboxylic Acid Ethyl Ester

trans-Ethyl 4-hydroxycyclohexanecarboxylate

3618-04-0, 17159-80-7, 75877-66-6

3618-04-0, 75877-66-6, 17159-80-7

Ethyl trans-4-hydroxycyclohexane-1-carboxylate

Ethyltrans-4-Hydroxycyclohexanecarboxylate&gt

Cyclohexanecarboxylic acid, 4-hydroxy-, ethyl ester, trans-

trans-Ethyl (1r,4r)-4-hydroxycyclohexane-1-carboxylate

(1R,4R)-ethyl 4-hydroxycyclohexanecarboxylate

(Trans)-ethyl 4-hydroxycyclohexane-1-carboxylate

3618-04-0