MONASTROL
- Product Name
- MONASTROL
- CAS No.
- 329689-23-8
- Chemical Name
- MONASTROL
- Synonyms
- CS-763;MONASTROL;(±)-Monastro;Monastrol, >=98%;MONASTROL (Free base);Ethyl 4-(3-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate;6-Methyl-4-(3-hydroxyphenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester;5-PyriMidinecarboxylic acid, 1,2,3,4-tetrahydro-4-(3-hydroxyphenyl)-6-Methyl-2-thioxo-, ethyl ester
- CBNumber
- CB92130960
- Molecular Formula
- C14H16N2O3S
- Formula Weight
- 292.35
- MOL File
- 329689-23-8.mol
MONASTROL Property
- Melting point:
- 190-193℃ (ethanol )
- Boiling point:
- 441.3±55.0 °C(Predicted)
- Density
- 1.34±0.1 g/cm3 (20 ºC 760 Torr)
- RTECS
- UV6262400
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly, Heated)
- form
- White to light yellow solid.
- pka
- 9.63±0.10(Predicted)
- color
- White to Off-White
- Sensitive
- Light Sensitive
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
N-Bromosuccinimide Price
- Product number
- J67096
- Product name
- Monastrol, 98%
- Packaging
- 5mg
- Price
- $250
- Updated
- 2023/06/20
- Product number
- 15044
- Product name
- Monastrol
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $68
- Updated
- 2024/03/01
- Product number
- 15044
- Product name
- Monastrol
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $104
- Updated
- 2024/03/01
- Product number
- 15044
- Product name
- Monastrol
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $135
- Updated
- 2024/03/01
- Product number
- 15044
- Product name
- Monastrol
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $502
- Updated
- 2024/03/01
MONASTROL Chemical Properties,Usage,Production
Uses
Monastrol is a small molecule that inhibits mitotic kinesin Eg5 and arrests cells in mitosis with monopolar spindles (1, 2).Monastrol is an anticancer agent against MCF-7 tumor cells (3).
Definition
ChEBI: A member of the class of thioureas that is 3,4-dihydropyrimidine-2(1)-thione substituted by a 3-hydroxyphenyl group at position 4, a methyl group at position 6 and a ethoxycarbonyl group at position 5.
Biological Activity
monastrol is a cell-permeable small molecule inhibitor of the mitotic kinesin, eg5. like other kinesins, eg5 can drive the movement of microtubules in vitro.
in vitro
previous study found that monastrol did not inhibit progression through s and g2 phases of the cell cycle or centrosome duplication. the mitotic arrest due to monastrol was also reversible rapidly. chromosomes in monastrol-treated cells frequently had both sister kinetochores attached to microtubules extending to the center of the monoaster. monastrol also inhibited bipolar spindle formation in xenopus egg extracts, however, monastrol did not prevent the targeting of eg5 to the monoastral spindles that form [1].
in vivo
previous study investigated the rat pk and tk of lasom 65, a monastrol derivative. results showed that lasom 65 had good bioavailability and linear pk after oral doses. lasom 65 distributed consistently in lung and fatty tissues. other investigated tissues presented smaller penetration ratios. adverse symptoms were observed only after iv administration, and regressed 3 h after dosing. no statistical differences were found for serum analysis, body weight and relative organ weight, indicating no acute toxicological effects. [2].
IC 50
14 μm
References
[1] kapoor tm,mayer tu,coughlin ml,mitchison tj. probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, eg5. j cell biol.2000 sep 4;150(5):975-88.
[2] torres bg,ucha fde t,pigatto mc,azeredo fj,haas se,dallegrave e,canto rf,eifler-lima vl,dalla costa t. pre-clinical pharmacokinetics and acute toxicological evaluation of a monastrol derivative anticancer candidate lasom 65 in rats. xenobiotica.2014 mar;44(3):254-63.
MONASTROL Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from MONASTROL manufacturers
- Product
- Monastrol 329689-23-8
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2020-01-10