(1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-Octahydro-1-,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenemethanamine hydrochloride
- Product Name
- (1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-Octahydro-1-,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenemethanamine hydrochloride
- CAS No.
- 16496-99-4
- Chemical Name
- (1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-Octahydro-1-,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenemethanamine hydrochloride
- Synonyms
- Dehydroabietylamine Hydrochloride;DehydroabiethylaMine Hydrochloride;(+)-DehydroabiethylaMine Hydrochloride;13-Isopropyl-podocarpa-8,11,13-trien-15-aMine Hydrochloride;[(1R,4aS,10aR)-1,4a-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthren-1-yl]methanamine;((1S,4aS)-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-1-yl)methanamine hydrochloride;(1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-Octahydro-1-,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenemethanamine hydrochloride
- CBNumber
- CB92134908
- Molecular Formula
- C20H32ClN
- Formula Weight
- 321.93
- MOL File
- 16496-99-4.mol
(1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-Octahydro-1-,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenemethanamine hydrochloride Property
- storage temp.
- -20°
- solubility
- Soluble in DMSO (up to 40 mg/ml) or in Water (up to 9 mg/ml).
- form
- solid
- color
- Off-white or beige
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- J63123
- Product name
- (+)-Dehydroabietylamine hydrochloride
- Packaging
- 10mg
- Price
- $125.65
- Updated
- 2024/03/01
- Product number
- J63123
- Product name
- (+)-Dehydroabietylamine hydrochloride
- Packaging
- 50mg
- Price
- $540.65
- Updated
- 2024/03/01
- Product number
- 10008614
- Product name
- Leelamine (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 10008614
- Product name
- Leelamine (hydrochloride)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $84
- Updated
- 2024/03/01
- Product number
- 10008614
- Product name
- Leelamine (hydrochloride)
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $341
- Updated
- 2024/03/01
(1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-Octahydro-1-,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenemethanamine hydrochloride Chemical Properties,Usage,Production
Description
Leelamine HCl (16496-99-4) is a lysosomotropic, intracellular cholesterol transport inhibitor with potential chemotherapeutic activity. Induces cholesterol accumulation in lysosomal/endosomal cell compartments via inhibition of autophagic flux.1?Induces apoptosis in breast cancer2, melanoma3?and prostate cancer cells4. A selective inducer of cytochrome P450 2B.5?Inhibits pyruvate dehydrogenase kinase (PDK), IC50=9.5 μM.6
Uses
Resolving agent for carboxylic acids
Uses
Dehydroabiethylamine is a primary amine with high molecular weight; shows a strong antibiotic effect with a broad spectrum of activity against Staphylococcus p.a. (sic), Escherichia coli, Mycobacterium tuberculosis, and Candida albicans.
References
1) Kuzu?et al.?(2014),?Leelamine mediated cancer cell death through inhibition of intracellular cholesterol transport; Mol. Cancer Ther.,?13?1690 2) Sehrawat?et al.?(2017),?Cancer-selective death of human breast cancer cells by leelamine is mediated by bax and bak activation; Am. Mol. Carcinolg.,?56?337 3) Chen?et al. (2017),?Targeting cholesterol transport in circulating melanoma cells to inhibit metastasis; Pigment Cell Melanoma Res.,?30?541 4) Singh?et al. (2018),?Therapeutic Potential of Leelamine, a Novel Inhibitor of Androgen Receptor and Castration-Resistant Prostate Cancer; Mol. Cancer Ther.,?17?2079 5) Sim?et al.?(2015),?Selective induction of hepatic cytochrome P450 2B activity by leelamine in vivo, as a potent novel inducer; Arch. Pharm. Res.,?38?725 6) Aicher?et al.?(1999),?Triterpene and diterpene inhibitors of pyruvate dehydrogenase kinase (PDK); Bioorg. Med. Chem. Lett.,?9?2223
(1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-Octahydro-1-,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenemethanamine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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