6-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-1-CARBOXYLIC ACID
Uses- Product Name
- 6-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-1-CARBOXYLIC ACID
- CAS No.
- 1260643-32-0
- Chemical Name
- 6-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-1-CARBOXYLIC ACID
- Synonyms
- 6-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-1-CARBOXYLIC ACID;1-Isoquinolinecarboxylic acid, 6-bromo-1,2,3,4-tetrahydro-
- CBNumber
- CB9215544
- Molecular Formula
- C10H10BrNO2
- Formula Weight
- 256.1
- MOL File
- Mol file
6-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-1-CARBOXYLIC ACID Property
- Boiling point:
- 415.6±45.0 °C(Predicted)
- Density
- 1.593±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 1.71±0.20(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H332Harmful if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P330Rinse mouth.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CD11312647
- Product name
- 6-Bromo-1,2,3,4-tetrahydroisoquinoline-1-carboxylicacid
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $188
- Updated
- 2021/12/16
- Product number
- 50R0038
- Product name
- 6-Bromo-1,2,3,4-tetrahydro-isoquinoline-1-carboxylicacid
- Purity
- 96%
- Packaging
- 100mg
- Price
- $212
- Updated
- 2021/12/16
- Product number
- 50R0038
- Product name
- 6-Bromo-1,2,3,4-tetrahydro-isoquinoline-1-carboxylicacid
- Purity
- 96%
- Packaging
- 250mg
- Price
- $325
- Updated
- 2021/12/16
- Product number
- 1260643320
- Product name
- 6-Bromo-1,2,3,4-tetrahydroisoquinoline-1-carboxylicacid
- Packaging
- 1g
- Price
- $400
- Updated
- 2021/12/16
- Product number
- CM142919
- Product name
- 6-Bromo-1,2,3,4-tetrahydroisoquinoline-1-carboxylicacid
- Purity
- 95%
- Packaging
- 1g
- Price
- $426
- Updated
- 2021/12/16
6-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-1-CARBOXYLIC ACID Chemical Properties,Usage,Production
Uses
6-Bromo-1,2,3,4-Tetrahydroisoquinoline-1-carboxylic acid, as an important tetrahydroisoquinoline derivative, is used in the manufacture of highly effective insecticides, color films and dyes, and also has important pharmacological effects, such as vasodilatory, antitumor, antihypertensive, antiarrhythmic, and antithrombotic activities.
Synthesis
In a three-necked flask, 200mL of tetrahydrofuran, 35.0g of methyl 3-bromophenyl ethylcarbamate and 50mL of concentrated sulfuric acid were added, and the reaction was heated to reflux. At the end of the reaction, it was poured into 500mL of ice water, extracted with dichloromethane (150mL X 3 ), the combined organic phases were washed with water, washed with saturated brine, dried with anhydrous sodium sulfate, and concentrated to obtain 6-bromo-2-methoxycarbonyl-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid 38.9g (91.3%).
Synthesis of 6-bromo-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid: 35.0g of 6-bromo-2-methoxycarbonyl-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid and 200mL of 10M sulfuric acid were added into a triple-necked vial and reacted at reflux for 6 h. After the reaction, the pH was adjusted to 7 with sodium bicarbonate, cooled down, and a solid precipitated by filtration, which was dried to obtain 6- Bromo-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid 21.8g (76.4%).
6-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-1-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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