2-BROMO-1-FLUORO-4-(METHOXYMETHYL) BENZENE
- Product Name
- 2-BROMO-1-FLUORO-4-(METHOXYMETHYL) BENZENE
- CAS No.
- 887268-22-6
- Chemical Name
- 2-BROMO-1-FLUORO-4-(METHOXYMETHYL) BENZENE
- Synonyms
- 2-BROMO-4-(METHOXYMETHYL)FLUOROBENZENE;2-BROMO-1-FLUORO-4-(METHOXYMETHYL) BENZENE;Benzene, 2-bromo-1-fluoro-4-(methoxymethyl)-
- CBNumber
- CB9216925
- Molecular Formula
- C8H8BrFO
- Formula Weight
- 219.05
- MOL File
- Mol file
2-BROMO-1-FLUORO-4-(METHOXYMETHYL) BENZENE Property
- Boiling point:
- 219.7±25.0 °C(Predicted)
- Density
- 1.470±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
Safety
- Hazard Codes
- Xi
- Hazard Note
- Irritant
- HS Code
- 2903998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 2707-B-56
- Product name
- 2-Bromo-4-(methoxymethyl)fluorobenzene
- Purity
- 95.0%
- Packaging
- 1g
- Price
- $93
- Updated
- 2021/12/16
- Product number
- HCH0002840
- Product name
- 2-BROMO-4-(METHOXYMETHYL)FLUOROBENZENE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1048.82
- Updated
- 2021/12/16
- Product number
- 25252
- Product name
- 2-Bromo-1-fluoro-4-(methoxymethyl)benzene
- Purity
- 97%
- Packaging
- 500mg
- Price
- $59
- Updated
- 2021/12/16
- Product number
- A647574
- Product name
- 2-Bromo-1-fluoro-4-(methoxymethyl)benzene
- Purity
- 95%
- Packaging
- 1g
- Price
- $68
- Updated
- 2021/12/16
- Product number
- CD12016214
- Product name
- 2-Bromo-1-fluoro-4-(methoxymethyl)benzene
- Purity
- 95+%
- Packaging
- 1g
- Price
- $104
- Updated
- 2021/12/16
2-BROMO-1-FLUORO-4-(METHOXYMETHYL) BENZENE Chemical Properties,Usage,Production
Synthesis
77771-03-0
74-88-4
887268-22-6
To a solution of 3-bromo-4-fluorobenzyl alcohol (5.00 g, 24.4 mmol) in anhydrous N,N-dimethylformamide (50 mL) was added a suspension of 60% sodium hydride in mineral oil (1.37 g, 34.2 mmol) in batches at 0 °C. The reaction mixture was stirred at 0 °C for 30 min. Subsequently, iodomethane (4.15 g, 29.3 mmol) was added at the same temperature. The mixture was gradually warmed to room temperature and stirring was continued for 1 hour. Upon completion of the reaction, the reaction was quenched by the addition of water (200 mL) and extracted with ethyl acetate (3 x 200 mL). The organic layers were combined, washed with brine (50 mL), dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated in vacuum and the residue was purified by column chromatography using a petroleum ether solution of 2% to 5% ethyl acetate as eluent to afford the target product 2-bromo-1-fluoro-4-methoxymethylbenzene as a colorless oil (4.50 g, 84% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 7.57 (dd, J=6.4,2.0 Hz, 1H), 7.28-7.23 (m, 1H), 7.11 (t, J=8.0 Hz, 1H), 4.42 (s, 2H), 3.41 (s, 3H).
References
[1] Patent: US2018/162868, 2018, A1. Location in patent: Paragraph 1534-1535
[2] Patent: US2004/220194, 2004, A1. Location in patent: Page 23
[3] Patent: US2005/239795, 2005, A1. Location in patent: Page/Page column 20
2-BROMO-1-FLUORO-4-(METHOXYMETHYL) BENZENE Preparation Products And Raw materials
Raw materials
Preparation Products
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