Anisomelic acid
- Product Name
- Anisomelic acid
- CAS No.
- 59632-76-7
- Chemical Name
- Anisomelic acid
- Synonyms
- Nsc272354;Anisomelolide;Anisomelic acid;(6E,10Z,14Z)-6,14-dimethyl-3-methylidene-2-oxo-3a,4,5,8,9,12,13,15a-octahydrocyclotetradeca[b]furan-10-carboxylic acid;(3aR,6E,10Z,14E,15aS)-2,3,3a,4,5,8,9,12,13,15a-Decahydro-6,14-dimethyl-3-methylene-2-oxocyclotetradeca[b]furan-10-carboxylic acid;Cyclotetradeca[b]furan-10-carboxylic acid, 2,3,3a,4,5,8,9,12,13,15a-decahydro-6,14-dimethyl-3-methylene-2-oxo-, (3aR,6E,10Z,14E,15aS)-
- CBNumber
- CB92243761
- Molecular Formula
- C20H26O4
- Formula Weight
- 330.42
- MOL File
- 59632-76-7.mol
Anisomelic acid Property
- InChIKey
- SORYERHBQFTRIK-PUWPUPSASA-N
- SMILES
- O1C(=O)C(=C)[C@@]2([H])CCC(C)=CCCC(C(O)=O)=CCCC(C)=C[C@]12[H] |t:10,17,22|
Anisomelic acid Chemical Properties,Usage,Production
Description
Anisomelic acid: a cembrane-type macrocyclic diterpenoid possesses both anticancer and antiviral activity
Anisomelic acid (AA) is one of the principle bioactive compounds isolated from the plant Anisomeles malabarica. It is a membrane-type macrocyclic diterpenoid that presents potent cytotoxicity. It possesses both anticancer and antiviral activity. Researchers have studied the mode of action of AA-mediated apoptosis, indicating that AA inhibits the expression of the E6 and E7 viral proteins. In addition, AA is also effective in inducing apoptosis in other HPV-positive cervical cancer cells, with a high degree of specificity to HPV-positive cells and insignificant effects on HPV-negative cells[1-2].
References
[1] Rajendran Senthilkumar. “Synthesis and Evaluation of Anisomelic acid-like Compounds for the Treatment of HPV-Mediated Carcinomas.” Scientific Reports (2019): 20295.
[2] Christo Paul Preethy. “Analysis of the Cytotoxic Potential of Anisomelic Acid Isolated from Anisomeles malabarica.” Scientia Pharmaceutica 81 2 (2013): 559–66.
Anisomelic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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