2-METHYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID
Application- Product Name
- 2-METHYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID
- CAS No.
- 54329-54-3
- Chemical Name
- 2-METHYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID
- Synonyms
- AKOS BB-8836;CHEMBRDG-BB 4400181;2-methyl-3,4-dihydro-1H-isoquinoline-3-carboxylic acid;1,2,3,4-Tetrahydro-2-methyl-3-isoquinolinecarboxylic acid;2-METHYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID;3-Isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-2-Methyl-;2-methyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid(SALTDATA: HCl);2-Methyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrobromide≥ 95% (NMR)
- CBNumber
- CB9225325
- Molecular Formula
- C11H13NO2
- Formula Weight
- 191.23
- MOL File
- 54329-54-3.mol
2-METHYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID Property
- Boiling point:
- 343.0±42.0 °C(Predicted)
- Density
- 1.198±0.06 g/cm3 (20 ºC 760 Torr)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 2.22±0.20(Predicted)
- InChI
- InChI=1S/C11H13NO2/c1-12-7-9-5-3-2-4-8(9)6-10(12)11(13)14/h2-5,10H,6-7H2,1H3,(H,13,14)
- InChIKey
- SKFOSDNQLGCEHM-UHFFFAOYSA-N
- SMILES
- C1C2=C(C=CC=C2)CC(C(O)=O)N1C
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
N-Bromosuccinimide Price
- Product number
- B101673
- Product name
- 2-Methyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylicAcid
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- P000039884
- Product name
- 2-Methyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $68
- Updated
- 2021/12/16
- Product number
- P000039884
- Product name
- 2-Methyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $19
- Updated
- 2021/12/16
- Product number
- P000039884
- Product name
- 2-Methyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $27
- Updated
- 2021/12/16
- Product number
- 027815
- Product name
- 2-Methyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
- Packaging
- 1g
- Price
- $308
- Updated
- 2021/12/16
2-METHYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID Chemical Properties,Usage,Production
Application
DL-2-methyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid can be used as an organic synthesis intermediate and a pharmaceutical intermediate, mainly in laboratory research and development processes and chemical production processes.
Chemical Properties
White to off-white crystalline powder
Synthesis
67123-97-1
54329-54-3
GENERAL STEPS: Preparation of Example 3 2-methyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid 0.364 g (2.07 mmol) of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid was dissolved in 25 mL of formic acid. To this solution was added 2.5 mL of 37% formaldehyde solution. The resulting mixture was heated to reflux for about 17 hours. Upon completion of the reaction, the mixture was cooled and concentrated under reduced pressure to give a gummy substance. The gummy was dissolved in 3.0 mL of water and the pH was adjusted with hydrochloric acid to 2. Subsequently, purification was carried out using ion exchange chromatography (Dowex 50x-8, 100 mesh) to give 0.21 g of yellow powdery product in 53% yield. Product characterization data: 1H NMR (DMSO-d6): δ 2.56 (s, 3H), 3.01 (m, 2H), 3.48 (t, 1H), 3.9 (dd, 2H), 7.05 (m, 1H), 7.13 (m, 3H). MS (FD): m/e 192 (M+2).
References
[1] Patent: US5491166, 1996, A
2-METHYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID Preparation Products And Raw materials
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