3-Chloro-5-methylaniline
- Product Name
- 3-Chloro-5-methylaniline
- CAS No.
- 29027-20-1
- Chemical Name
- 3-Chloro-5-methylaniline
- Synonyms
- m-Toluidine, 5-chloro-;3-chloro-5-aminotoluene;3-Amino-5-chlorotoluene;3-Chloro-5-methylaniline;3-chloro-5-MethylbenzenaMine;3-Chloro-5-methylaniline,95%;3-Chloro-5-methylaniline 98%;3-Chloro-5-methyl-phenylamine;Benzenamine, 3-chloro-5-methyl-
- CBNumber
- CB92265594
- Molecular Formula
- C7H8ClN
- Formula Weight
- 141.6
- MOL File
- 29027-20-1.mol
3-Chloro-5-methylaniline Property
- Boiling point:
- 248.6±20.0℃ (760 Torr)
- Density
- 1.180±0.06 g/cm3 (20 ºC 760 Torr)
- Flash point:
- 104.1±21.8℃
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- form
- Solid
- pka
- 3.66±0.10(Predicted)
- Appearance
- Light yellow to brown Liquid
- Sensitive
- Light Sensitive
- InChI
- InChI=1S/C7H8ClN/c1-5-2-6(8)4-7(9)3-5/h2-4H,9H2,1H3
- InChIKey
- XUZCJDBXXYJXDD-UHFFFAOYSA-N
- SMILES
- C1(N)=CC(C)=CC(Cl)=C1
Safety
- HazardClass
- 6.1
- HS Code
- 2921420090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H373May cause damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C349795
- Product name
- 3-Chloro-5-methylaniline
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- C349795
- Product name
- 3-Chloro-5-methylaniline
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 3730-5-51
- Product name
- 3-Chloro-5-methylaniline
- Packaging
- 5G
- Price
- $56
- Updated
- 2021/12/16
- Product number
- 079788
- Product name
- 3-Chloro-5-methylaniline
- Purity
- 99%
- Packaging
- 5g
- Price
- $58
- Updated
- 2021/12/16
- Product number
- 076509
- Product name
- 3-Chloro-5-methylaniline
- Purity
- 95+%
- Packaging
- 1g
- Price
- $121
- Updated
- 2021/12/16
3-Chloro-5-methylaniline Chemical Properties,Usage,Production
Synthesis
16582-38-0
29027-20-1
General procedure for the synthesis of 3-chloro-5-methylaniline from 3-chloro-5-nitrotoluene: To an ethanol solution (75 mL) containing 1-chloro-3-methyl-5-nitrobenzene (5.0 g, 29 mmol) was added tin chloride dihydrate (SnCl2-2H2O, 32.8 g, 146 mmol). The reaction mixture was heated to reflux for 3.0 hours. Upon completion of the reaction, the solution was concentrated under reduced pressure and the residue was redissolved in aqueous sodium hydroxide solution, filtered and extracted with ethyl acetate (EtOAc). The organic layers were combined, washed with saturated brine, dried over anhydrous magnesium sulfate (MgSO4) and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography to afford 3-chloro-5-methylaniline (4.0 g, 97% yield) as a light yellow solid. The structure of the product was confirmed by 1H NMR (500 MHz, CDCl3) and ESI-MS: 1H NMR δ 6.56 (s, 1H), 6.48 (s, 1H), 6.36 (s, 1H), 3.66 (bs, 2H), 2.23 (s, 3H); ESI-MS: m/z 141.7 ([M + H]+).
References
[1] Patent: US2011/230486, 2011, A1. Location in patent: Page/Page column 31-32
[2] Patent: WO2013/82324, 2013, A1. Location in patent: Paragraph 00358
[3] Journal of Medicinal Chemistry, 2000, vol. 43, # 25, p. 4726 - 4737
[4] Patent: US2004/147776, 2004, A1. Location in patent: Page 2
[5] Patent: WO2008/113760, 2008, A2. Location in patent: Page/Page column 137
3-Chloro-5-methylaniline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Chloro-5-methylaniline manufacturers
- Product
- 3-Chloro-5-methylaniline 29027-20-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-11