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3-Chloro-5-methylaniline

Product Name
3-Chloro-5-methylaniline
CAS No.
29027-20-1
Chemical Name
3-Chloro-5-methylaniline
Synonyms
m-Toluidine, 5-chloro-;3-chloro-5-aminotoluene;3-Amino-5-chlorotoluene;3-Chloro-5-methylaniline;3-chloro-5-MethylbenzenaMine;3-Chloro-5-methylaniline,95%;3-Chloro-5-methylaniline 98%;3-Chloro-5-methyl-phenylamine;Benzenamine, 3-chloro-5-methyl-
CBNumber
CB92265594
Molecular Formula
C7H8ClN
Formula Weight
141.6
MOL File
29027-20-1.mol
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3-Chloro-5-methylaniline Property

Boiling point:
248.6±20.0℃ (760 Torr)
Density 
1.180±0.06 g/cm3 (20 ºC 760 Torr)
Flash point:
104.1±21.8℃
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
form 
Solid
pka
3.66±0.10(Predicted)
Appearance
Light yellow to brown Liquid
Sensitive 
Light Sensitive
InChI
InChI=1S/C7H8ClN/c1-5-2-6(8)4-7(9)3-5/h2-4H,9H2,1H3
InChIKey
XUZCJDBXXYJXDD-UHFFFAOYSA-N
SMILES
C1(N)=CC(C)=CC(Cl)=C1
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Safety

HazardClass 
6.1
HS Code 
2921420090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C349795
Product name
3-Chloro-5-methylaniline
Packaging
100mg
Price
$45
Updated
2021/12/16
TRC
Product number
C349795
Product name
3-Chloro-5-methylaniline
Packaging
1g
Price
$75
Updated
2021/12/16
SynQuest Laboratories
Product number
3730-5-51
Product name
3-Chloro-5-methylaniline
Packaging
5G
Price
$56
Updated
2021/12/16
Oakwood
Product number
079788
Product name
3-Chloro-5-methylaniline
Purity
99%
Packaging
5g
Price
$58
Updated
2021/12/16
Matrix Scientific
Product number
076509
Product name
3-Chloro-5-methylaniline
Purity
95+%
Packaging
1g
Price
$121
Updated
2021/12/16
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3-Chloro-5-methylaniline Chemical Properties,Usage,Production

Synthesis

16582-38-0

29027-20-1

General procedure for the synthesis of 3-chloro-5-methylaniline from 3-chloro-5-nitrotoluene: To an ethanol solution (75 mL) containing 1-chloro-3-methyl-5-nitrobenzene (5.0 g, 29 mmol) was added tin chloride dihydrate (SnCl2-2H2O, 32.8 g, 146 mmol). The reaction mixture was heated to reflux for 3.0 hours. Upon completion of the reaction, the solution was concentrated under reduced pressure and the residue was redissolved in aqueous sodium hydroxide solution, filtered and extracted with ethyl acetate (EtOAc). The organic layers were combined, washed with saturated brine, dried over anhydrous magnesium sulfate (MgSO4) and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography to afford 3-chloro-5-methylaniline (4.0 g, 97% yield) as a light yellow solid. The structure of the product was confirmed by 1H NMR (500 MHz, CDCl3) and ESI-MS: 1H NMR δ 6.56 (s, 1H), 6.48 (s, 1H), 6.36 (s, 1H), 3.66 (bs, 2H), 2.23 (s, 3H); ESI-MS: m/z 141.7 ([M + H]+).

References

[1] Patent: US2011/230486, 2011, A1. Location in patent: Page/Page column 31-32
[2] Patent: WO2013/82324, 2013, A1. Location in patent: Paragraph 00358
[3] Journal of Medicinal Chemistry, 2000, vol. 43, # 25, p. 4726 - 4737
[4] Patent: US2004/147776, 2004, A1. Location in patent: Page 2
[5] Patent: WO2008/113760, 2008, A2. Location in patent: Page/Page column 137

3-Chloro-5-methylaniline Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Chloro-5-methylaniline Suppliers

Canada 1 China 84 India 2 United Kingdom 2 United States 7 Global 96
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Aceschem Inc.
Tel
+1-817863-6948 +1-（817）863-6948
Email
sales@aceschem.com
Country
United States
ProdList
19632
Advantage
58
Synthonix Inc
Tel
--
Fax
--
Email
info@synthonix.com
Country
United States
ProdList
6872
Advantage
58
Wilshire Chemical Company Inc.
Tel
--
Fax
--
Email
WilshrChem@AOL.COM
Country
United States
ProdList
3498
Advantage
58
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
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View Lastest Price from 3-Chloro-5-methylaniline manufacturers

Career Henan Chemical Co
Product
3-Chloro-5-methylaniline 29027-20-1
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2019-07-11

29027-20-1, 3-Chloro-5-methylanilineRelated Search:


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  • 3-Chloro-5-methylaniline
  • 3-chloro-5-MethylbenzenaMine
  • m-Toluidine, 5-chloro-
  • 3-Chloro-5-methylaniline 98%
  • 3-Chloro-5-methyl-phenylamine
  • Benzenamine, 3-chloro-5-methyl-
  • 3-Chloro-5-methylaniline,95%
  • 3-chloro-5-aminotoluene
  • 29027-20-1