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DMT-dC(bz) Phosphoramidite

Product Name
DMT-dC(bz) Phosphoramidite
CAS No.
102212-98-6
Chemical Name
DMT-dC(bz) Phosphoramidite
Synonyms
DMT-dC(Bz)-CE;DMT-dC(bz) amidite;DNAC-PHOSPHORAMIDITE;Bz-dC Phosphoramidite;DMT-dC(Bz)-CE Amidites;DMT-dC-CEPhosphoramidite;2'-dC(Bz)Phosphoramidite;dC(Bz) CE Phosphoramidite;DMT-dC(bz) Phosphoramidite;dC (N-Bz) Phosphoramidite
CBNumber
CB9226852
Molecular Formula
C46H52N5O8P
Formula Weight
833.91
MOL File
102212-98-6.mol
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DMT-dC(bz) Phosphoramidite Property

Melting point:
>84°C (dec.)
Density 
1.23 at 20℃
vapor pressure 
0-0Pa at 20-50℃
storage temp. 
Sealed in dry,2-8°C
solubility 
Chloroform, DMSO, Methanol (Slightly)
form 
powder or granules
pka
8.65±0.20(Predicted)
color 
white to off-white
InChI
InChI=1/C46H52N5O8P/c1-32(2)51(33(3)4)60(57-29-13-27-47)59-40-30-43(50-28-26-42(49-45(50)53)48-44(52)34-14-9-7-10-15-34)58-41(40)31-56-46(35-16-11-8-12-17-35,36-18-22-38(54-5)23-19-36)37-20-24-39(55-6)25-21-37/h7-12,14-26,28,32-33,40-41,43H,13,29-31H2,1-6H3,(H,48,49,52,53)/t40-,41+,43+,60?/s3
InChIKey
PGTNFMKLGRFZDX-SALLYJDFSA-N
SMILES
O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C=CC(NC(=O)C3=CC=CC=C3)=NC2=O)C[C@@H]1OP(N(C(C)C)C(C)C)OCCC#N |&1:25,27,45,r|
LogP
6.5 at 20℃
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Safety

Safety Statements 
24/25
WGK Germany 
3
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C111040
Product name
DMT-dC(bz) Phosphoramidite
Purity
configured for MerMade
Packaging
6x5g
Price
$737
Updated
2024/03/01
Sigma-Aldrich
Product number
C111040
Product name
DMT-dC(bz) Phosphoramidite
Purity
configured for MerMade
Packaging
6x10g
Price
$982
Updated
2024/03/01
Sigma-Aldrich
Product number
C111000
Product name
DMT-dC(bz) Phosphoramidite
Purity
≥99% (31P-NMR)
Packaging
6x10g
Price
$982
Updated
2024/03/01
Sigma-Aldrich
Product number
C111000
Product name
DMT-dC(bz) Phosphoramidite
Packaging
208.6g
Price
$3430
Updated
2024/03/01
Sigma-Aldrich
Product number
C111000
Product name
DMT-dC(bz) Phosphoramidite
Purity
≥99% (31P-NMR)
Packaging
1kg
Price
$13480
Updated
2024/03/01
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DMT-dC(bz) Phosphoramidite Chemical Properties,Usage,Production

Chemical Properties

DMT-dC(bz) Phosphoramidite, also known as 5'-O-DMT-N4-Benzoyl-2'-Deoxycytidine-CE Phosphoramidite or (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite (IUPAC Name), is a novel nucleoside amidite analog, which can be subjected in the synthesis of DNA.
DMT-dC(bz) Phosphoramidite belongs to the group of DNA Phosphoramidites.Its key features include:
Exocyclic amine functions are protected by a benzoyl group (dA(bz) anddC(bz)) or isobutyryl group (dG(ib))
Recommended cleavage and deprotection conditions are 8 hours at 55 °Cor 24 hours at room temperature using concentrated ammonia solution, for standard base-protected oligonucleotides
The high coupling efficiency of Proligo′s DNA phosphoramidites leads to high-yield and high-quality oligonucleotides.

Uses

5'-O-DMT-N4-Benzoyl-2'-deoxycytidine 3'-CE phosphoramidite is used to prepare antisense oligonucleotides containing conformationally constrained methoxyaminomethylene and aminooxymethylene and aminomethylene bridged nucleoside analogs.

Synthesis


These Examples illustrate the phosphitylation of several protected nucleoside reagents with 2-Cyanoethyl-N,N,N',N'-tetraisopropylphosphordiamidite in the presence of several activators according to the present invention. Eleven phosphitylation reactions (1-11) comprising reacting a protected nucleoside reagent with 2-Cyanoethyl-N,N,N',N'-tetraisopropylphosphordiamidite in the presence of an acid-base activator according to the present invention were conducted, and the product yields of each calculated, as described in the General Procedure, below. The various combinations of protected nucleoside, activator base, activator acid, solvent, and yield for each of the 11 reactions are listed in Table 1. General Procedure: The activator base (1.1 to 1.2 equivalents) is added to the solvent and 0.95 to 1.1 equivalents of activator acid is subsequently added thereto at ambient temperature to form the activator solution. About 1 equivalent of the protected nucleoside is dissolved in about 10 equivalents of the solvent in a separate vessel and about 3 equivalents of the solvent is then distilled off under reduced pressure. About 1 to 1.2 equivalents of 2-Cyanoethyl-N,N,N',N'-tetraisopropylphosphordiamidite is added to the nucleoside mixture at ambient temperature, and the activator solution prepared previously is then added to the nucleoside mixture at ambient temperature with vigorous stirring. After 12 hours, the reaction mixture is diluted with toluene and washed with water. The organic layer is separated, dried over sodium sulfate if necessary, and concentrated under reduced pressure. The yield of the desired amidite is then calculated using HPLC techniques, that is, the resulting product mixture is run through an HPLC column using an appropriate eluent, and the area under the HPLC peaks used to determine the %yield of product in the mixture.

DMT-dC(bz) Phosphoramidite Preparation Products And Raw materials

Raw materials

Preparation Products

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DMT-dC(bz) Phosphoramidite Suppliers

Canada 1 China 161 Germany 1 India 5 South Korea 1 Switzerland 1 United Kingdom 3 United States 13 Global 186
Hefei Huana Biomedical Technology Co.,Ltd
Tel
17333066501
Email
shengwen.fang@huanaok.com.cn
Country
China
ProdList
95
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58
Shanghai Peinuo Biotechnology Co., Ltd
Tel
021-58648778 18217200601
Fax
QQ:99286241
Email
bush@perno.cn
Country
China
ProdList
292
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58
Nanjing Youwei Biotechnology Co., Ltd
Tel
025-86506605 13952030024
Fax
QQ：24810051
Email
13811988123@139.com
Country
China
ProdList
24
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58
Tianjin Scaxchem Limited Compnay
Tel
022-022-25327698 18920479040
Email
sales@cosychem.com
Country
China
ProdList
589
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55
Nugene Biopharm Science (Hangzhou) Co., Ltd.
Tel
13326014885
Email
service@nugene.com.cn
Country
China
ProdList
55
Advantage
58
Nanjing Searchem Co., Ltd.
Tel
15105140861
Email
sikai@searchem.cn
Country
China
ProdList
63
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58
Wuhu Huaren Science and Technology Co., Ltd.
Tel
0553-0553-0553-5842013-801-801 18155347026
Fax
086-553-5843138
Email
jinhuaren@huarensh.com
Country
China
ProdList
295
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64
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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76
Hongene Biotech Corporation
Tel
021-64757213
Fax
86-21-64700613
Email
info@hongene.com
Country
China
ProdList
672
Advantage
61
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
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59
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View Lastest Price from DMT-dC(bz) Phosphoramidite manufacturers

Hefei Huana Biomedical Technology Co.,Ltd.
Product
DMT-dC(Bz)-CE 102212-98-6
Price
US $0.00/mg
Min. Order
100mg
Purity
≥99%
Supply Ability
20tons
Release date
2023-03-09
SHANGHAI NOVRIBO BIOTECH
Product
dC(Bz) CE Phosphoramidite 102212-98-6
Price
US $100.00/kg
Min. Order
0.009999999776482582kg
Purity
99%
Supply Ability
5tons
Release date
2023-03-21
Henan Aochuang Chemical Co.,Ltd.
Product
5'-O-DMT-N4-Benzoyl-2'-deoxycytidine 3'-CE phosphoramidite 102212-98-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-23

102212-98-6, DMT-dC(bz) PhosphoramiditeRelated Search:

Cytidine Benzoyl peroxide 3-Chloropropyltrimethoxysilane 3-Aminopropyltriethoxysilane Benzoyl chloride Triethyl phosphonoacetate BENZOYL ISOCYANATE Cytidine-5'-triphosphate disodium salt dihydrate 3-Chloropropyltriethoxysilane Cytarabine 5'-O-Dimethoxytrityl-N-benzoyl-desoxycytidine 2'-Deoxycytidine N-blocked-5'-O-DMT-2'-O-Me CED cytosine phosphoramidite 5'-O-FDMT-N4-BENZOYL-2'-DEOXYCYTIDINE CEP 5-HYDROXY-DC CEP 5-BROMO-DC CEP N-blocked-5'-O-DMT-2'-O-TBDMS CED cytidine phosphoramidite DMT-dC(bz) Phosphoramidite

  • REF DUPL: DMT-dC(bz) Phosphoramidite
  • Bz-dC Phosphoramidite
  • N4-Benzoyl-2'-deoxy-5'-O-DMT-cytidine 3'-CE phosphoramidite ,98%
  • N4-Benzoyl-2'-deoxy-5'-O-DMT-cytidine 3'-CE phosphoramidite
  • 2'-DEOXYCYTIDINE PHOSPHORAMIDITE
  • DNAC-PHOSPHORAMIDITE
  • dC (N-Bz) Phosphoramidite
  • N-blocked-5'-O-DMT 3'-CED deoxycytidine phosphoramidite
  • (2R,3S,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-yl 2-cyanoethyl diisopropylphosphoramidite
  • DMT-dC(bz) Phosphoramidite
  • 5'-O-DMT-N4-Benzoyl-2'-deoxycytidine 3'-CE phosphoramidite
  • DMT-DC(BZ) AMIDITE 2G AB 12 PACK
  • 3'-O-P-5'-O-DMT-N-BZ-2'-DEOXY-CYTIDINE [DC(BZ) PHOSPHORAMIDITE]
  • 5'-Dimethoxytrityl-N-benzoyl-3'-deoxyCytidine,3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
  • DMT-dC-CEPhosphoramidite
  • N<sup>4</sup>-Benzoyl-2'-deoxy-5'-O-DMT-cytidine 3'-CE phosphoramidite, 99%, R and S mixture
  • N<sup>4</sup>-Benzoyl-2'-deoxy-5'-O-DMT-cytidine 3'-CE phosphoraMidite
  • DMT-dC(bz) Amidite 1g, 89, 12 Pack
  • DMT-dC(bz) Amidite 20g, 6 Pack
  • DMT-DC(BZ) AMIDITE 5G 6 PACK
  • DMT-dC(bz) Amidite 4g, 60ml vial, 12 Pac
  • DMT-dC(bz) Amidite 2g, 60ml vial, 12 Pac
  • DMT-DC(BZ) AMIDITE 10G 6 PACK
  • DMT-DC(BZ) AMIDITE 10G SINGLE
  • DMT-DC(BZ) AMIDITE 1G AB 12 PACK
  • DMT-dC(bz) Amidite 1g, 60ml vial, 12 Pac
  • DMT-dC(bz) Amidite 7.65g, 6 Pack
  • DMT-DC(BZ) AMIDITE 5G SINGLE
  • DMT-DC(BZ) AMIDITE 2G 89 12 PACK
  • N4-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxycytidine-3′-O-[O-(2-cyanoethyl)-N,N′-diisopropylphosphoramidite]
  • N6-Benzoyl-5'-O-DMT-2'-deoxycytidine-3'-CE Phosphoramidite
  • DMT-dC(Bz)-CE Phosphoramidite
  • N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine-3'-cyanoethyl Phosphoramidite
  • DMT-dC(bz) amidite
  • n-benzoyl-5'-o-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-cytidine 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
  • N4-BENZOYL-5'-O-(DIMETHOXYTRITYL)-2'-DEOXYCYTIDINE-3'-N,N-DIISOPROPYL (CYANOETHYL) PHOSPHORAMIDITE
  • 5'-O-(4,4'-DIMETHOXYTRITYL)-N4-BENZOYL-2'-DEOXYCYTIDINE-3'-(2-CYANOETHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE
  • dC(bz) β-Cyanoethylphosphoramidite (mixture of isomers)isomers)
  • Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
  • N4-Benzoyl-5'-O-DMT-2'-deoxycytidine 3'-CE phosphoramidite
  • DMT-dC(bz) Phosphoramidite USP/EP/BP
  • 5'-DMT-Bz-dC phosphoramidite
  • 5'-Dimethoxytrityl-N-benzoyl-2'-deoxyCytidine,3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
  • N4-Benzoyl-5'-O-(4,4'-DMT)-2’-dC-3'-CE Phosphoramidite
  • 5-O-(4,4-Dimethoxytrityl)-N4-benzoyl-2-deoxycytidine-3-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
  • 5'-O-DMT-N4-Benzoyl-2'-Deoxycytidine-CE Phosphoramidite
  • DMT-dC(Bz)-CE
  • N-[1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide
  • dC(Bz) CE Phosphoramidite
  • 5'-O-DMT-N4-Benzoyl-2'-Deoxy Cytidine-3’-Cyanoethyl Phosphoramidite
  • deoxy N-Bz Cytidine Amidite
  • DMT-dC(Bz)-CE Amidites
  • N -Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine-3'-cyanoethyl-N,N-diisopropylphosphoramidite(DMT-dC(bz)phosphoramidite)(Ac-dC phosphoramidite)
  • DMTr-dC(Bz)-3'-CE-Phosphoramidite
  • Bz dC Beta-Cyanoethyl Phosphoramidite (500 mg) (5'-O-Dimethoxytrityl-N4-benzoyl-2'-deoxycytidine-3'-O-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite)
  • N-[1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenyl-methoxy]methyl]-4-[2-cyanoethoxy-(diisopropylamino)phosphanyl]oxy-tetrahydrofuran-2-yl]-2-oxo-pyrimidin-4-yl]benzamide
  • 5'-O-DMT-N4-Benzoyl-2'-Deoxycytidine-CE Phosphoramidite
  • 5'-O-DMT-N4-Benzoyl-2'-deoxycytidine 3'-CE phosphoramidite