Spongosine
- Product Name
- Spongosine
- CAS No.
- 24723-77-1
- Chemical Name
- Spongosine
- Synonyms
- GL101375;BVT-115959;Spongosine;2-Methoxyadenosine;Adenosine, 2-methoxy-;Regadenoson Impurity 59;Spongosine, 10 mM in DMSO;Regadenoson Impurity 8 (Spongosine);2-Methoxy-9-pentofuranosyl-9H-purin-6-amine;2-Methoxyadenosine, Spongosine, Regadenosone impurity 8
- CBNumber
- CB92336364
- Molecular Formula
- C11H15N5O5
- Formula Weight
- 297.27
- MOL File
- 24723-77-1.mol
Spongosine Property
- storage temp.
- Store at 0-8 °C
- solubility
- DMSO: Slightly soluble: 0.1-1 mg/ml
- Boiling point:
- 705.0±70.0 °C(Predicted)
- Density
- 1.98±0.1 g/cm3(Predicted)
- Melting point:
- 193 °C
- pka
- 13.07±0.70(Predicted)
- form
- Solid
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CM237924
- Product name
- (2R,3R,4S,5R)-2-(6-Amino-2-methoxy-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
- Purity
- 97%
- Packaging
- 100mg
- Price
- $435
- Updated
- 2021/12/16
- Product number
- CD70001609
- Product name
- (2R,3R,4S,5R)-2-(6-Amino-2-methoxy-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
- Purity
- 97%
- Packaging
- 100mg
- Price
- $465
- Updated
- 2021/12/16
- Product number
- 24723771
- Product name
- (2R,3R,4S,5R)-2-(6-Amino-2-methoxy-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
- Packaging
- 100mg
- Price
- $502.2
- Updated
- 2021/12/16
Spongosine Chemical Properties,Usage,Production
Uses
Spongosine (2-Methoxyadenosine) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
References
[1] Man S, et al. Potential and promising anticancer drugs from adenosine and its analogs. Drug Discov Today. 2021 Jun;26(6):1490-1500. DOI:10.1016/j.drudis.2021.02.020
[2] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005
[3] PHILIP A. SEARLE Tadeusz F M. Isolation of Spongosine and 2’-Deoxyspongosine from a Western Australian Sponge of the Order Hadromerida (Tethyidae)[J]. Journal of Natural Products , 1994, 57 10: 1452-1454. DOI: 10.1021/np50112a018
[4] ZHAN-GUO GAO. 2-Substituted adenosine derivatives: affinity and efficacy at four subtypes of human adenosine receptors[J]. Biochemical pharmacology, 2004, 68 10: Pages 1985-1993. DOI: 10.1016/j.bcp.2004.06.011
[5] L. OJHA. A Simple Method for Synthesis of Spongosine, Azaspongosine, and Their Antiplatelet Effects[J]. Nucleosides, Nucleotides & Nucleic Acids, 1995, 14 1: 1889-1900. DOI: 10.1080/15257779508010711
[6] FREDERICK A. FUHRMAN Geraldine J F. Effects of some naturally-occurring purine ribosides on purinergic receptors in cardiac and smooth muscle[J]. Comparative biochemistry and physiology. C: Comparative pharmacology, 1982, 72 2: Pages 203-210. DOI: 10.1016/0306-4492(82)90085-5
Spongosine Preparation Products And Raw materials
Raw materials
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