5-(BROMOMETHYL)-4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOLE

Product Name: 5-(BROMOMETHYL)-4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOLE
CAS No.: 439134-78-8
Chemical Name: 5-(BROMOMETHYL)-4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOLE
Synonyms: 5-(BroMoMethyl)-4-Methyl-2-(4-(trifluoroMethyl)phenyl)thiazole;Thiazole, 5-(bromomethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-;5-(BROMOMETHYL)-4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOLE
CBNumber: CB9237478
Molecular Formula: C12H9BrF3NS
Formula Weight: 336.17
MOL File: 439134-78-8.mol

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5-(BROMOMETHYL)-4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOLE Property

Melting point:: 64 °C
Boiling point:: 373.7±52.0 °C(Predicted)
Density: 1.551±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 1.58±0.10(Predicted)

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Safety

HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Apolloscientific

Product number: PC446072
Product name: 5-Bromomethyl-4-methyl-2-(4-trifluoromethyl-phenyl)-thiazole
Packaging: 250mg
Price: $90
Updated: 2021/12/16

SynQuest Laboratories

Product number: 7H70-B-00
Product name: 5-Bromomethyl-4-methyl-2-(4-trifluoromethylphenyl)thiazole
Packaging: 250mg
Price: $144
Updated: 2021/12/16

Apolloscientific

Product number: PC446072
Product name: 5-Bromomethyl-4-methyl-2-(4-trifluoromethyl-phenyl)-thiazole
Packaging: 1g
Price: $254
Updated: 2021/12/16

AK Scientific

Product number: 6062AB
Product name: 5-(Bromomethyl)-4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole
Packaging: 1g
Price: $354
Updated: 2021/12/16

Matrix Scientific

Product number: 094932
Product name: 5-(Bromomethyl)-4-methyl-2-(4-(trifluoromethyl)-phenyl)thiazole
Purity: 95+%
Packaging: 250mg
Price: $364
Updated: 2021/12/16

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5-(BROMOMETHYL)-4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOLE Chemical Properties,Usage,Production

Synthesis

317318-96-0

439134-78-8

GENERAL STEPS: (4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methanol (15.0 g, 55.0 mmol) obtained in Example 2 was dissolved in anhydrous dichloromethane (300 mL). Triphenylphosphine (TPP, 5.7 g, 60.0 mmol, 1.1 eq.) and tetrabromomethane (20.0 g, 60.0 mmol, 1.1 eq.) were added sequentially to the mixture at room temperature. After 1 h of reaction, the solvent was removed by evaporation under reduced pressure. The residual triphenylphosphine oxide was precipitated with a mixture of hexane and ethyl acetate (v/v = 5/1), filtered and evaporated under reduced pressure to afford 5-(bromomethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole (17.2 g, yield: 93%).1H-NMR (300 MHz, CDCl3): δ 8.00 (d, 2H, J = 8.1 Hz), 7.67 (d, 2H, J = 8.2 Hz), 4.72 (s, 2H), 2.47 (s, 3H).13C-NMR (78.5 MHz, CDCl3): δ 165.0, 153.8, 136.9, 132.4, 129.7 (q), 127.0, 126.3 (m), 122.5, 23.8. 15.5.

References

[1] Journal of Medicinal Chemistry, 2007, vol. 50, # 4, p. 685 - 695
[2] Patent: WO2003/106442, 2003, A1. Location in patent: Page 13
[3] Patent: WO2006/121223, 2006, A1. Location in patent: Page/Page column 15
[4] Patent: WO2003/106442, 2003, A1. Location in patent: Page 13-14
[5] Patent: WO2006/121223, 2006, A1. Location in patent: Page/Page column 15

5-(BROMOMETHYL)-4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-(BROMOMETHYL)-4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOLE Suppliers

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439134-78-8, 5-(BROMOMETHYL)-4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOLERelated Search:

5-(BROMOMETHYL)-4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOLE 5-(BROMOMETHYL)-4-METHYL-2-PHENYL-1,3-THIAZOLE

5-(BROMOMETHYL)-4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOLE

5-(BroMoMethyl)-4-Methyl-2-(4-(trifluoroMethyl)phenyl)thiazole

Thiazole, 5-(bromomethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-

439134-78-8

C12H9BrF3NS