5α-Androstane-3,6,17-trione

5α-Androstane-3,6,17-trione Property

Melting point:

188.5-190.5 °C

Boiling point:

452.2±45.0 °C(Predicted)

Density 

1.147±0.06 g/cm3(Predicted)

solubility 

DMF: 50 mg/mL; DMF:PBS(pH 7.2)(1:1): 0.5 mg/mL; DMSO: 30 mg/mL; Ethanol: 5 mg/mL

form 

A crystalline solid

Safety

DEA Controlled Substances

CSCN: 4000
CSA SCH: Schedule III
NARC: No

Hazard and Precautionary Statements (GHS)

5α-Androstane-3,6,17-trione Chemical Properties,Usage,Production

Description

5α-Androstan-3,6,17-trione is an analog of 4-androstene-3,6,17-trione (4-AT, 6-OXO), an irreversible aromatase inhibitor that is used to increase serum androgen levels. 5α-Androstan-3,6,17-trione is considered a designer drug and is regulated in the United States. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.

Uses

(5α)-Androstane-3,6,17-trione is identified as biotransformation products of testosterone. Also, it is an aromatase inhibitor in human placental microsomes.

References

[1] MITSUTERU NUMAZAWA  Ayako M  Masachika Tsuji. Studies on aromatase inhibition with 4-androstene-3,6,17-trione: Its 3β-reduction and time-dependent irreversible binding to aromatase with human placental microsomes[J]. Journal of steroid biochemistry, 1987, 28 3: Pages 337-344. DOI: 10.1016/0022-4731(87)91028-4
[2] DAN ROHLE. Effects of eight weeks of an alleged aromatase inhibiting nutritional supplement 6-OXO (androst-4-ene-3,6,17-trione) on serum hormone profiles and clinical safety markers in resistance-trained, eugonadal males.[J]. Journal of the International Society of Sports Nutrition, 2007, 4: 13. DOI: 10.1186/1550-2783-4-13