ETHYL 2-ETHOXY-4-METHYLBENZOATE
- Product Name
- ETHYL 2-ETHOXY-4-METHYLBENZOATE
- CAS No.
- 88709-17-5
- Chemical Name
- ETHYL 2-ETHOXY-4-METHYLBENZOATE
- Synonyms
- Tolperisone Impurity 9;Repaglinide Impurity 18;ETHYL 2-ETHOXY-4-METHYLBENZOATE;Benzoic acid, 2-ethoxy-4-methyl-, ethyl ester
- CBNumber
- CB92449822
- Molecular Formula
- C12H16O3
- Formula Weight
- 208.26
- MOL File
- 88709-17-5.mol
ETHYL 2-ETHOXY-4-METHYLBENZOATE Property
- Boiling point:
- 156 °C(Press: 5 Torr)
- Density
- 1.038±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H319Causes serious eye irritation
H335May cause respiratory irritation
H373May cause damage to organs through prolonged or repeated exposure
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P314Get medical advice/attention if you feel unwell.
P337+P313IF eye irritation persists: Get medical advice/attention.
P391Collect spillage. Hazardous to the aquatic environment
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- E917958
- Product name
- Ethyl2-ethoxy-4-methylbenzoate
- Packaging
- 50mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 4563AC
- Product name
- Ethyl2-ethoxy-4-methylbenzoate
- Packaging
- 5g
- Price
- $597
- Updated
- 2021/12/16
- Product number
- CHM0167268
- Product name
- ETHYL-2-ETHOXY-4-METHYLBENZOATE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $820.05
- Updated
- 2021/12/16
- Product number
- A211669
- Product name
- Ethyl2-ethoxy-4-methylbenzoate
- Purity
- 97%
- Packaging
- 250mg
- Price
- $48
- Updated
- 2021/12/16
- Product number
- CD12016335
- Product name
- Ethyl2-ethoxy-4-methylbenzoate
- Purity
- 97%
- Packaging
- 10g
- Price
- $632
- Updated
- 2021/12/16
ETHYL 2-ETHOXY-4-METHYLBENZOATE Chemical Properties,Usage,Production
Synthesis
74-96-4
50-85-1
88709-17-5
1. To a well-stirred solution of 4-methylsalicylic acid (25 g, 0.164 mol) in dimethyl sulfoxide (75 ml) was added potassium carbonate (68.0 g, 0.492 mol). 2. The reaction mixture was stirred at 35-40 °C and the first batch of ethyl bromide (27.0 g, 0.247 mol) was added slowly over 30 min and stirring was continued for 2 h. The reaction mixture was then stirred for 2 h at the same temperature. 3. Subsequently, a second batch of ethyl bromide (27.0 g, 0.247 mol) was added over 30 min at the same temperature. 4. The reaction mixture was continued to be stirred at 35-40°C for 8 hours. 5. After completion of the reaction, it was cooled to 20-25 °C and diluted with dichloromethane (50 ml). 6. The inorganic salts were removed by filtration and the solid residue was washed with dichloromethane. 7. The filtrate and washings were combined, diluted with water (50 ml) and the organic layer was separated by stirring for 30 minutes. 8. The aqueous layer was further extracted with dichloromethane, all dichloromethane layers were combined and washed with 2 x 50 ml of water. 9. Finally, the solvent was evaporated under reduced pressure to give 34.2 g of ethyl 2-ethoxy-4-methylbenzoate in quantitative yield.
References
[1] Patent: US6686497, 2004, B1. Location in patent: Page column 3-4
[2] Organic Process Research and Development, 2002, vol. 6, # 2, p. 184 - 186
[3] Patent: WO2016/34673, 2016, A1. Location in patent: Page/Page column 103
[4] Journal of Medicinal Chemistry, 1998, vol. 41, # 26, p. 5219 - 5246
ETHYL 2-ETHOXY-4-METHYLBENZOATE Preparation Products And Raw materials
Raw materials
Preparation Products
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