ChemicalBook > CAS DataBase List > 2-(5-FLUORO-1H-INDOL-3-YL)ETHANOL

2-(5-FLUORO-1H-INDOL-3-YL)ETHANOL

Product Name: 2-(5-FLUORO-1H-INDOL-3-YL)ETHANOL
CAS No.: 101349-12-6
Chemical Name: 2-(5-FLUORO-1H-INDOL-3-YL)ETHANOL
Synonyms: 5-Fluorotryptophol;5-Fluoro-1H-indole-3-ethanol;1H-INDOLE-3-ETHANOL,5-FLUORO-;5-FLUORO-3-HYDROXYETHYL-INDOLE;2-(5-Fluoro-1h-indol-3-yl)ethano;2-(5-FLUORO-1H-INDOL-3-YL)ETHANOL;5-Fluoro-3-(2-hydroxyethyl)indole;2-(5-fluoro-1H-indol-3-yl)ethan-1-ol
CBNumber: CB92450271
Molecular Formula: C10H10FNO
Formula Weight: 179.19
MOL File: 101349-12-6.mol

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2-(5-FLUORO-1H-INDOL-3-YL)ETHANOL Property

Melting point:: 89-91℃
Boiling point:: 361.2±27.0 °C(Predicted)
Density: 1.313±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 14.87±0.10(Predicted)
Appearance: Off-white to yellow Solid

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: F597713
Product name: 2-(5-Fluoro-1H-indol-3-yl)ethanol
Packaging: 100mg
Price: $75
Updated: 2021/12/16

ChemScene

Product number: CS-0052263
Product name: 2-(5-Fluoro-1H-indol-3-yl)ethan-1-ol
Purity: >97.0%
Packaging: 5g
Price: $113
Updated: 2021/12/16

AK Scientific

Product number: 1785AL
Product name: 2-(5-Fluoro-1H-indol-3-yl)ethanol
Packaging: 1g
Price: $116
Updated: 2021/12/16

Apolloscientific

Product number: PC903647
Product name: 2-(5-Fluoro-1H-indol-3-yl)ethanol
Purity: 95%
Packaging: 250mg
Price: $150
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-3-8A
Product name: 2-(5-Fluoro-1H-indol-3-yl)ethan-1-ol
Purity: 97.0%
Packaging: 250mg
Price: $190
Updated: 2021/12/16

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2-(5-FLUORO-1H-INDOL-3-YL)ETHANOL Chemical Properties,Usage,Production

Synthesis Reference(s)

The Journal of Organic Chemistry, 51, p. 1704, 1986 DOI: 10.1021/jo00360a014

Synthesis

443-73-2

101349-12-6

General procedure for the synthesis of 2-(5-fluoro-1H-indol-3-yl)ethanol from 5-fluoroindole-3-acetic acid: 5-fluoroindole-3-acetic acid (1 g, 5.2 mmol) was dissolved in anhydrous THF (10 mL) under argon protection, and the ice bath was cooled to 0°C. A 1 M solution of lithium aluminum hydride in THF (10.4 mL, 10.4 mmol) was added slowly dropwise. After the dropwise addition was completed, the ice bath was removed and the reaction mixture was heated to reflux and kept at reflux for 1.5 hours. Upon completion of the reaction, the mixture was cooled to 0°C and the reaction was quenched by the slow addition of water (0.39 mL), 1% NaOH aqueous solution (0.39 mL), and water (0.2 mL) in that order. The insoluble precipitate was removed by vacuum filtration and the filtrate was concentrated under reduced pressure to afford the target product 2-(5-fluoro-1H-indol-3-yl)ethanol as an orange oil (0.927 g, 100% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 2.98 (t, J = 6.41 Hz, 2H), 3.89 (t, J = 6.18 Hz, 2H), 6.95 (td, J = 9.04, 2.52 Hz, 1H), 7.12 (s, 1H), 7.22-7.30 (m, 2H), 8.06 (br s, 1H). 1H).

References

[1] Journal of Medicinal Chemistry, 2004, vol. 47, # 15, p. 3823 - 3842
[2] Patent: WO2017/85484, 2017, A1. Location in patent: Page/Page column 76; 77
[3] Angewandte Chemie - International Edition, 2017, vol. 56, # 5, p. 1402 - 1406
[4] Angew. Chem., 2016, vol. 129, p. 1423 - 1427,5
[5] Organic Letters, 2006, vol. 8, # 20, p. 4397 - 4400

2-(5-FLUORO-1H-INDOL-3-YL)ETHANOL Preparation Products And Raw materials

Raw materials

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View Lastest Price from 2-(5-FLUORO-1H-INDOL-3-YL)ETHANOL manufacturers

Career Henan Chemical Co

Product: 2-(5-FLUORO-1H-INDOL-3-YL)ETHANOL 101349-12-6
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Judy@coreychem.com
Release date: 2019-12-18

101349-12-6, 2-(5-FLUORO-1H-INDOL-3-YL)ETHANOLRelated Search:

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101349-12-6