ORITAVANCIN

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Product Name: ORITAVANCIN
CAS No.: 171099-57-3
Chemical Name: ORITAVANCIN
Synonyms: CS-2274;Orbactiv;LY 333328;ORITAVANCIN;Ollivan Star;brand name: Orbactiv;Oritavancin (LY333328);Oritavancin, trifluoacetate salt;Oritavancin (Lyophilized Powder For IV Infusion);rideoxy-3-methyl-α-L-arabino-hexopyranosyl)-β-D-g
CBNumber: CB92451283
Molecular Formula: C86H97Cl3N10O26
Formula Weight: 1793.1
MOL File: 171099-57-3.mol

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ORITAVANCIN Property

Density: 1.59±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
pka: 2.93±0.70(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0008111
Product name: ORITAVANCIN
Purity: 95.00%
Packaging: 5MG
Price: $496.02
Updated: 2021/12/16

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ORITAVANCIN Chemical Properties,Usage,Production

Definition

ChEBI: A semisynthetic glycopeptide used (as its bisphosphate salt) for the treatment of acute bacterial skin and skin structure infections caused or suspected to be caused by susceptible isolates of designated Gram-positive microorganisms including MRSA.

Clinical Use

Antibacterial agent

Enzyme inhibitor

This novel, semi-synthetic glycopeptide antibiotic (FW = 1793.10 g/mol; CAS 171099-57-3), also known as LY333328, Orbactiv?, and (4R)-22-O- (3-amino-2,3,6-trideoxy-3-C-methyl-a-L-arabinohexopyranosyl)-N3-(p-(pchlorophenyl) benzyl)vancomycin, disrupts the cell membrane of Grampositive bacteria and inhibits both transglycosylation and transpeptidation. Oritavancin differs from vancomycin by the presence of a hydrophobic N-4-(4-chlorophenyl)benzyl substituent on the disaccharide, the addition of a 4-epi-vancosamine monosaccharide to the amino acid residue in Ring-6, and replacement of the vancosamine moiety by 4-epi-vancosamine. When compared vancomycin, teicoplanin, and quinupristin-dalfopristin (Synercid) against 219 strains of enterococci and staphylococci, including vancomycin-resistant enterococci and methicillinresistant methicillinresistant Staphylococcus aureus, LY333328 demonstrated superior activity against vancomycin-resistant enterococci and was the only antibiotic which was bactericidal. Indeed, a single infusion of this antibiotic (1200 mg) can clear serious bacterial skin infections, including methicillin-resistant Staphylococcus aureus, or MRSA, as effectively as the usual 7-10 day, twice-daily regimen of vancomycin now needed to treat patients.

Drug interactions

Potentially hazardous interactions with other drugs
Anticoagulants: possibly increases warfarin concentration.

Metabolism

In vitro human liver microsome studies indicated that oritavancin is not metabolised. It is excreted unchanged; less than 1% and 5% of a dose is recovered in the urine and the faeces.

ORITAVANCIN Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from ORITAVANCIN manufacturers

Shaanxi Haibo Biotechnology Co., Ltd

Product: ORITAVANCIN 171099-57-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000ton
Release date: 2023-09-07

Qiuxian Baitai New Material Co., LTD

Product: ORITAVANCIN 171099-57-3
Price: US $12.00/g
Min. Order: 1KG
Purity: 99%
Supply Ability: 5ton/Month
Release date: 2021-11-22

Longyan Tianhua Biological Technology Co., Ltd

Product: ORITAVANCIN 171099-57-3
Price: US $20.00/KG
Min. Order: 1KG
Purity: 99
Supply Ability: 999
Release date: 2020-10-26

171099-57-3, ORITAVANCINRelated Search:

Levonorgestrel TMC-207 Iron-dextran DEXTRAN, 14C-METHYLATED Betamethasone METHYL-A-L-ACOSAMINE chloroorienticin B eremomycin H-D-LEU-NH2 HCL L-Acosaminehydrochloride [4-(4-CHLOROPHENYL)PHENYL]METHYLAMINE HYDROCHLORIDE Ritodrine hydrochloride ORITAVANCIN

ORITAVANCIN

Oritavancin (LY333328)

(4R)-22-O-(3-Amino-2,3,6-trideoxy-3-C-methyl-a-L-arabinohexopyranosyl)-N3-(p-(p-chlorophenyl)benzyl)vancomycin

(4''R)-22-O-(3-Amino-2,3,6-trideoxy-3-C-methyl-alpha-L-arabino-hexopyranosyl)-N3''-[(4'-chloro[1,1'-biphenyl]-4-yl)methyl]vancomycin

LY 333328

Orbactiv

Oritavancin (Lyophilized Powder For IV Infusion)

rideoxy-3-methyl-α-L-arabino-hexopyranosyl)-β-D-g

CS-2274

brand name: Orbactiv

LY333328; LY-333328; LY 333328; ORITAVANCIN; BRAND NAME: ORBACTIV

Vancomycin, 22-O-(3-amino-2,3,6-trideoxy-3-C-methyl-α-L-arabino-hexopyranosyl)-N3''-[(4'-chloro[1,1'-biphenyl]-4-yl)methyl]-, (4''R)-

Oritavancin, trifluoacetate salt

Vancomycin,22-O-(3-amino-2,3,6-trideoxy-3-C-methyl-a-L-arabino-hexopyranosyl)-N3''-[(4'-chloro[1,1'-biphenyl]-4-yl)methyl]-,(4''R)-

Ollivan Star

Vancomycin, 22-O-(3-amino-2,3,6-trideoxy-3-C-methyl-α-L-arabino-hexopyranosyl)-N3′′-[(4′-chloro[1,1′-biphenyl]-4-yl)methyl]-, (4′′R)-

171099-57-3

C86H97Cl3N10O26