ChemicalBook > CAS DataBase List > 5-Bromo-2,4-difluorobenzaldehyde

5-Bromo-2,4-difluorobenzaldehyde

Product Name
5-Bromo-2,4-difluorobenzaldehyde
CAS No.
473416-91-0
Chemical Name
5-Bromo-2,4-difluorobenzaldehyde
Synonyms
5-BroMo-2,4-difluorobenzaldehyde;BENZALDEHYDE, 5-BROMO-2,4-DIFLUORO
CBNumber
CB92451672
Molecular Formula
C7H3BrF2O
Formula Weight
221
MOL File
473416-91-0.mol
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5-Bromo-2,4-difluorobenzaldehyde Property

Boiling point:
229.4±35.0 °C(Predicted)
Density 
1.758±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
fused solid
color 
Faint lemon
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Safety

HS Code 
2913000090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B677795
Product name
5-Bromo-2,4-difluorobenzaldehyde
Packaging
500mg
Price
$75
Updated
2021/12/16
AK Scientific
Product number
V6085
Product name
5-Bromo-2,4-difluorobenzaldehyde
Packaging
5g
Price
$115
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0359240
Product name
5-BROMO-2,4-DIFLUOROBENZALDEHYDE
Purity
95.00%
Packaging
5MG
Price
$502.26
Updated
2021/12/16
AK Scientific
Product number
V6085
Product name
5-Bromo-2,4-difluorobenzaldehyde
Packaging
100g
Price
$691
Updated
2021/12/16
Apolloscientific
Product number
PC52118
Product name
5-Bromo-2,4-difluorobenzaldehyde
Packaging
1g
Price
$19
Updated
2021/12/16
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5-Bromo-2,4-difluorobenzaldehyde Chemical Properties,Usage,Production

Uses

5-Bromo-2,4-difluorobenzaldehyde is a fluorobenzaldehyde analogue, commonly used as a pharmaceutical intermediate.

Synthesis

28342-75-8

68-12-2

473416-91-0

General procedure for the synthesis of 5-bromo-2,4-difluorobenzaldehyde from 1,5-dibromo-2,4-difluorobenzene and N,N-dimethylformamide: 1,5-dibromo-2,4-difluorobenzene (17.5 g, 64.2 mmol) was dissolved in ether (100 mL) at -78 °C, and n-butyllithium (2.5 M, 30.8 mL, 77 mmol) was added slowly (2.5 M, 30.8 mL, 77 mmol), over a period of 5 minutes. The reaction mixture was continued to be stirred at -78 °C for 30 min. Subsequently, N,N-dimethylformamide (9.94 mL, 148 mmol) was added all at once and the mixture was stirred at the same temperature for another 30 minutes. After completion of the reaction, the reaction mixture was treated with ethyl acetate and saturated sodium bicarbonate solution. The crude product was purified by silica gel column chromatography using 0-10% ethyl acetate/hexane as eluent to afford the target compound 5-bromo-2,4-difluorobenzaldehyde as a light yellow oil (8.5 g, 60% yield). The product was characterized by 1H NMR (400 MHz, chloroform-d): δ10.26 (s, 1H), 8.14 (t, J=7.5 Hz, 1H), 7.05 (dd, J=9.8,8.0 Hz, 1H).

References

[1] Patent: US2011/9395, 2011, A1. Location in patent: Page/Page column 22
[2] Patent: WO2012/162334, 2012, A1. Location in patent: Page/Page column 38-39
[3] Patent: WO2014/98831, 2014, A1. Location in patent: Page/Page column 27

5-Bromo-2,4-difluorobenzaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-Bromo-2,4-difluorobenzaldehyde manufacturers

Career Henan Chemical Co
Product
BENZALDEHYDE, 5-BROMO-2,4-DIFLUORO 473416-91-0
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2020-02-17

473416-91-0, 5-Bromo-2,4-difluorobenzaldehydeRelated Search:

Benzaldehyde, 4-fluoro-2,3-dimethoxy- 4-CHLORO-2,6-DIFLUOROBENZALDEHYDE 5-Bromo-3-fluoro-2-methoxybenzaldehyde 5-BROMO-2 3-DIMETHOXYBENZALDEHYDE 97 4-bromo-2-formylbenzonitrile 5-(difluoromethoxy)-2,4-difluorobenzaldehyde 4-Hydroxy-2-methoxybenzaldehyde 4-Chloro-2-iodo-benzaldehyde 5-bromo-4-fluoro-2-methylbenzaldehyde 4-bromo-3-fluoro-5-methylbenzaldehyde 5-Bromo-2-ethylbenzaldehyde 3-BROMO-2,4,5,6-TETRAFLUOROBENZOYL CHLORIDE BENZALDEHYDE, 5-BROMO-2,4-DIFLUORO 3-BROMO-2,4,5-TRIFLUOROBENZOIC ACID

  • 5-BroMo-2,4-difluorobenzaldehyde
  • BENZALDEHYDE, 5-BROMO-2,4-DIFLUORO
  • 473416-91-0