ChemicalBook > CAS DataBase List > OTAVA-BB 7070707015

OTAVA-BB 7070707015

Product Name
OTAVA-BB 7070707015
CAS No.
934593-90-5
Chemical Name
OTAVA-BB 7070707015
Synonyms
W6;LW8;LW6;CAY10585;CAY10585，LW6;LW6(CAY10585);HIF-1α inhibitor;HIF-1α inhibitor;OTAVA-BB 7070707015;CAY 10585;CAY-10585;CAY10585;LW6
CBNumber
CB92452396
Molecular Formula
C26H29NO5
Formula Weight
435.51
MOL File
934593-90-5.mol
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OTAVA-BB 7070707015 Property

Boiling point:
647.4±55.0 °C(Predicted)
Density 
1.295±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:17.5(Max Conc. mg/mL);40.18(Max Conc. mM)
DMF:25.6(Max Conc. mg/mL);58.8(Max Conc. mM)
pka
7.59±0.48(Predicted)
form 
powder to crystal
color 
White to Light yellow to Light orange
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Safety

HS Code 
2924.29.7790
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10012682
Product name
CAY10585
Purity
≥97%
Packaging
1mg
Price
$16
Updated
2024/03/01
Cayman Chemical
Product number
10012682
Product name
CAY10585
Purity
≥97%
Packaging
5mg
Price
$63
Updated
2024/03/01
Cayman Chemical
Product number
10012682
Product name
CAY10585
Purity
≥97%
Packaging
10mg
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
10012682
Product name
CAY10585
Purity
≥97%
Packaging
25mg
Price
$235
Updated
2024/03/01
Tocris
Product number
6322
Product name
LW6
Purity
≥98%(HPLC)
Packaging
10
Price
$139
Updated
2021/12/16
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OTAVA-BB 7070707015 Chemical Properties,Usage,Production

Description

Hypoxia-inducible factor-1 (HIF-1) is a heterodimeric transcription factor composed of a HIF-1α subunit and HIF-1β subunit. Whereas the HIF-1β subunit is constitutively expressed, the HIF-1α subunit is regulated by cellular oxygen levels and therefore plays an important role in maintaining cellular oxygen homeostasis. Under normoxic conditions, HIF-1α is selectively hydroxylated on proline residues 402 and 577 and targeted for destruction by the ubiquitin-proteasome system. Under hypoxic conditions, HIF-1α accumulates and dimerizes with HIF-1β to promote the transcription of a number of genes involved in angiogenesis, glycolysis, growth factor signaling, tumor invasion, and metastasis. CAY10585 is a novel small molecule inhibitor of HIF-1α accumulation and gene transcriptional activity. In a gene reporter assay using human Hep3B and AGS cell lines, CAY10585 prevented HIF-1 transcriptional activity with IC50 values of 2.6 and 0.7 μM, respectively. It blocks HIF-1α accumulation in Hep3B cells in a concentration and time-dependent manner, with complete inhibition at a concentration of 30 μM within 12 hours. CAY10585 also significantly suppresses transcription of the HIF-1 target genes VEGF and erythropoietin at 10 μM.

Uses

CAY10585 is a class of hypoxia-inducible factor (HIF-1) responsible for radiation resistance and poor prognosis in cancer therapy.

storage

Store at -20°C

OTAVA-BB 7070707015 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from OTAVA-BB 7070707015 manufacturers

Career Henan Chemical Co
Product
OTAVA-BB 7070707015 934593-90-5
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
20kg
Release date
2019-12-23

934593-90-5, OTAVA-BB 7070707015Related Search:

METHYL 3-FORMYL-4-HYDROXYBENZOATE methyl 3-ethyl-2-oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxylate 3-Cyano-2-methylBenzoic acid methyl ester 2-Pyridinecarboxylic acid, 3-(bromomethyl)-4-(difluoromethyl)-, methyl ester METHYL 3-NITRO-1H-INDOLE-2-CARBOXYLATE methyl 3-ethynyl-2-(1H-indol-6-yl)benzoate METHYL 3,5-DIBROMO-4-HYDROXYBENZOATE methyl 3-bromo-4-(hexyloxy)benzoate Propanoic acid, 3-(3-bromophenoxy)-, methyl ester methyl 3-(((tert-butoxycarbonyl)(methyl)amino)methyl)-1-methyl-1H-pyrazole-5-carboxylate Methyl 3-fluoro-6-oxo-1,6-dihydropyridine-2-carboxylate Methyl 2-hydroxy-4-phenylbenzoate Methyl3-(4-(dibromomethyl)phenyl)acrylate

  • OTAVA-BB 7070707015
  • CAY10585
  • HIF-1α inhibitor
  • LW6
  • LW8
  • CAY 10585;CAY-10585;CAY10585;LW6
  • 4-Hydroxy-3-[[2-(4-tricyclo[3.3.1.13,7]dec-1-ylphenoxy)acetyl]aMino]-benzoic Acid Methyl Ester
  • Hypoxia inducible factor-1α inhibitor
  • LW 6 (This product is unavailable in the U.S.)
  • methyl 3-(2-(4-((1r,3r,5r,7r)-adamantan-2-yl)phenoxy)acetamido)-4-hydroxybenzoate
  • W6
  • Benzoic acid, 4-hydroxy-3-[[2-(4-tricyclo[3.3.1.13,7]dec-1-ylphenoxy)acetyl]amino]-, methyl ester
  • 3-[[[4-(Adamantan-1-yl)phenoxy]acetyl]amino]-4-hydroxybenzoic Acid Methyl Ester
  • Methyl 3-[[[4-(adamantan-1-yl)phenoxy]acetyl]amino]-4-hydroxybenzoate
  • methyl 3-(2-(4-(adamantan-1-yl)phenoxy)acetamido)-4-hydroxybenzoate
  • CAY10585，LW6
  • HIF-1α inhibitor
  • LW 6,Apoptosis,LW-8,Hypoxia-inducible factors,inhibit,HIF-PH,HIF/HIF Prolyl-Hydroxylase,LW6,LW-6,HIFs,Inhibitor,LW 8
  • LW6(CAY10585)
  • 934593-90-5
  • Aromatics, Inhibitors