ChemicalBook > CAS DataBase List > OTAVA-BB 7070707015

OTAVA-BB 7070707015

Product Name
OTAVA-BB 7070707015
CAS No.
934593-90-5
Chemical Name
OTAVA-BB 7070707015
Synonyms
W6;LW8;LW6;CAY10585;CAY10585，LW6;LW6(CAY10585);HIF-1α inhibitor;LW6, 10 mM in DMSO;OTAVA-BB 7070707015;CAY10585, HIF-1alpha inhibitor
CBNumber
CB92452396
Molecular Formula
C26H29NO5
Formula Weight
435.51
MOL File
934593-90-5.mol
More
Less

OTAVA-BB 7070707015 Property

Boiling point:
647.4±55.0 °C(Predicted)
Density 
1.295±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:17.5(Max Conc. mg/mL);40.18(Max Conc. mM)
DMF:25.6(Max Conc. mg/mL);58.8(Max Conc. mM)
pka
7.59±0.48(Predicted)
form 
powder to crystal
color 
White to Light yellow to Light orange
More
Less

Safety

HS Code 
2924.29.7790
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
10012682
Product name
CAY10585
Purity
≥97%
Packaging
1mg
Price
$16
Updated
2024/03/01
Cayman Chemical
Product number
10012682
Product name
CAY10585
Purity
≥97%
Packaging
5mg
Price
$63
Updated
2024/03/01
Cayman Chemical
Product number
10012682
Product name
CAY10585
Purity
≥97%
Packaging
10mg
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
10012682
Product name
CAY10585
Purity
≥97%
Packaging
25mg
Price
$235
Updated
2024/03/01
Tocris
Product number
6322
Product name
LW6
Purity
≥98%(HPLC)
Packaging
10
Price
$139
Updated
2021/12/16
More
Less

OTAVA-BB 7070707015 Chemical Properties,Usage,Production

Description

Hypoxia-inducible factor-1 (HIF-1) is a heterodimeric transcription factor composed of a HIF-1α subunit and HIF-1β subunit. Whereas the HIF-1β subunit is constitutively expressed, the HIF-1α subunit is regulated by cellular oxygen levels and therefore plays an important role in maintaining cellular oxygen homeostasis. Under normoxic conditions, HIF-1α is selectively hydroxylated on proline residues 402 and 577 and targeted for destruction by the ubiquitin-proteasome system. Under hypoxic conditions, HIF-1α accumulates and dimerizes with HIF-1β to promote the transcription of a number of genes involved in angiogenesis, glycolysis, growth factor signaling, tumor invasion, and metastasis. CAY10585 is a novel small molecule inhibitor of HIF-1α accumulation and gene transcriptional activity. In a gene reporter assay using human Hep3B and AGS cell lines, CAY10585 prevented HIF-1 transcriptional activity with IC50 values of 2.6 and 0.7 μM, respectively. It blocks HIF-1α accumulation in Hep3B cells in a concentration and time-dependent manner, with complete inhibition at a concentration of 30 μM within 12 hours. CAY10585 also significantly suppresses transcription of the HIF-1 target genes VEGF and erythropoietin at 10 μM.

Uses

CAY10585 is a class of hypoxia-inducible factor (HIF-1) responsible for radiation resistance and poor prognosis in cancer therapy.

storage

Store at -20°C

OTAVA-BB 7070707015 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

OTAVA-BB 7070707015 Suppliers

Canada 1 China 75 Europe 1 India 2 Japan 1 United States 8 Global 88
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4674
Advantage
55
Shanghai TaoSu Biochemical Technology Co., Ltd.
Tel
021-33632979
Fax
021-34692979
Email
info@tsbiochem.com
Country
China
ProdList
8065
Advantage
58
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3466
Advantage
58
SPIRO PHARMA
Tel
Fax
-
Email
eric_feng1954@126.com
Country
China
ProdList
9248
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9805
Advantage
58
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
5960
Advantage
55
ShangHai Biochempartner Co.,Ltd
Tel
17754423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8011
Advantage
62
Shanghai Rechem science Co., Ltd.
Tel
21-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2951
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Country
China
ProdList
29764
Advantage
68
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
Twochem Co.Ltd.
Tel
021-58111628 15800915896
Fax
QQ 3285589261
Email
sales@twochem.com
Country
China
ProdList
1788
Advantage
58
SuZhou Medinoah Co.,LTD.
Tel
0512-69561983 13914027025
Fax
0512-69561982
Email
zhang_q@medinoah.com
Country
China
ProdList
4098
Advantage
58
Angel Pharmatech, Ltd.
Tel
17317130613
Fax
QQ3358272972
Email
3358272972@qq.com
Country
China
ProdList
3254
Advantage
58
Zhengzhou Acme Chemical Co., Ltd.
Tel
0371-63315541 13323832564
Fax
QQ:3001332135
Email
3001332135@qq.com
Country
China
ProdList
10034
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57423
Advantage
58
Guangzhou Tomums Life Science Co., Ltd.
Tel
020-31155029 18902330969
Fax
020-31155029
Email
sales@tomums.cn
Country
China
ProdList
4696
Advantage
58
TCI Chemicals
Tel
021-67121386, 800-988-0390
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
5391
Advantage
58
Tianjin Kaifu Pharmaceutical Technology Co., Ltd.
Tel
18081075745
Email
chemflowtech@sina.com
Country
China
ProdList
1886
Advantage
58
DC Chemicals
Tel
021-58447131 13564518121
Email
sales@dcchemicals.com
Country
China
ProdList
9409
Advantage
58
Changzhou Chenhong Biotechnology Co., Ltd.
Tel
0519-85788828 13775037613
Email
sales@chemrenpharm.com
Country
China
ProdList
3600
Advantage
58
career henan chemical co
Tel
+86-0371-86658258 +8613203830695
Fax
0086-371-86658258
Email
factory@coreychem.com
Country
China
ProdList
29809
Advantage
58
Shanghai Zeye Biotechnology Co., Ltd.
Tel
021-61998551 13122364865
Email
sale1@shzysw.net
Country
China
ProdList
9772
Advantage
58
Guangzhou Younan Technology Co., Ltd
Tel
020-82000279 18988968278
Fax
QQ：3283937693
Email
sales@ubiochem.com
Country
China
ProdList
4297
Advantage
58
Absin Bioscience Inc.
Tel
021-38015121 15000105423
Email
wulan@absin.cn
Country
China
ProdList
24731
Advantage
58
Shanghai hongqu biomedical technology co. LTD
Tel
88888888888
Email
hongquchem@qq.com
Country
China
ProdList
5132
Advantage
58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
Tel
+86-021-61551413 +8618813727289
Email
contact@trustwe.com
Country
China
ProdList
5738
Advantage
58
Cangzhou Pintuo Biotechnology Co., Ltd.
Tel
15231732623
Email
1979763395@qq.com
Country
China
ProdList
187
Advantage
58
CHG Opto-Electronic Corporation Limited
Tel
2537653158 16621191650
Fax
QQ 2537653158
Email
2537653158@qq.com
Country
China
ProdList
7140
Advantage
58
Advanced chemblocks inc
Tel
650-6922368
Email
sales@achemblock.com
Country
China
ProdList
2992
Advantage
58
ShangHai ChuanQian Chemcial Technique Centre
Tel
15869524721
Email
3525679403@qq.com
Country
China
ProdList
4342
Advantage
58
Abmole Bioscience Inc.
Tel
021-50967598 02150967598
Email
sales@abmole.cn
Country
China
ProdList
4494
Advantage
58
Jinan Jiuli Biotechnology Co. , Ltd.
Tel
15865264761
Email
486064515@qq.com
Country
China
ProdList
4996
Advantage
58
Zhengzhou convergence chemical co., LTD
Tel
0371-0371-55153829 18003835034
Fax
18003835034（微信）
Email
2853979819@qq.com
Country
China
ProdList
9813
Advantage
58
Shanghai tingchong biology science and technology co., ltd
Tel
18964309092 18964309092
Email
2769493375@qq.com
Country
China
ProdList
2634
Advantage
58
ChemeGen 中国
Tel
18818260767
Fax
QQ 3610331285
Email
2625930290@qq.com
Country
China
ProdList
6973
Advantage
58
Hefei Ruiluo New Material Technology Co., Ltd.
Tel
19567218739
Email
1759672789@qq.com
Country
China
ProdList
972
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
Country
China
ProdList
62075
Advantage
58
Kaifeng Mingren Pharmaceutical Co.,LTD
Tel
0371-65741762
Fax
QQ：2860768577
Email
sales@hasunny.com
Country
China
ProdList
2380
Advantage
58
InvivoChem
Tel
13549236410
Email
sales@invivochem.cn
Country
China
ProdList
6753
Advantage
58
Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.
Tel
+86-027-59232304 15387063101
Email
2881924050@qq.com
Country
China
ProdList
9997
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24644
Advantage
58
Shanghai Maclean Biochemical Technology Co., LTD
Tel
021-50706066 15221275939
Email
shenlinxing@macklin.cn
Country
China
ProdList
30016
Advantage
58
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
18621169109
Email
market03@meryer.com
Country
China
ProdList
27987
Advantage
58
Shanghai Tachizaki Biomedical Research Center
Tel
18014399201
Email
sales@chemlab-tachizaki.com
Country
China
ProdList
2619
Advantage
58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd
Tel
18049165724 13186333400
Email
cuichengbio@163.com
Country
China
ProdList
4023
Advantage
58
Nanjing Tengyi Biotechnology Co., Ltd
Tel
025-58851786 17714337195
Email
sales@tybiochem.com
Country
China
ProdList
6827
Advantage
58
Abosyn
Tel
0512-69561983 13914027025
Email
he_qf@medinoah.com
Country
China
ProdList
3001
Advantage
58
Shanghai Jieshikai Biotechnology Co. , Ltd.
Tel
021-57520305 15801958784
Email
lihua@jskchem.com
Country
China
ProdList
49234
Advantage
58
More
Less

View Lastest Price from OTAVA-BB 7070707015 manufacturers

Career Henan Chemical Co
Product
OTAVA-BB 7070707015 934593-90-5
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
20kg
Release date
2019-12-23

934593-90-5, OTAVA-BB 7070707015Related Search:

METHYL 3-FORMYL-4-HYDROXYBENZOATE methyl 3-ethyl-2-oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxylate 3-Cyano-2-methylBenzoic acid methyl ester 2-Pyridinecarboxylic acid, 3-(bromomethyl)-4-(difluoromethyl)-, methyl ester METHYL 3-NITRO-1H-INDOLE-2-CARBOXYLATE methyl 3-ethynyl-2-(1H-indol-6-yl)benzoate METHYL 3,5-DIBROMO-4-HYDROXYBENZOATE methyl 3-bromo-4-(hexyloxy)benzoate Propanoic acid, 3-(3-bromophenoxy)-, methyl ester methyl 3-(((tert-butoxycarbonyl)(methyl)amino)methyl)-1-methyl-1H-pyrazole-5-carboxylate Methyl 3-fluoro-6-oxo-1,6-dihydropyridine-2-carboxylate Methyl 2-hydroxy-4-phenylbenzoate Methyl3-(4-(dibromomethyl)phenyl)acrylate

  • OTAVA-BB 7070707015
  • CAY10585
  • HIF-1α inhibitor
  • LW6
  • LW8
  • CAY 10585;CAY-10585;CAY10585;LW6
  • 4-Hydroxy-3-[[2-(4-tricyclo[3.3.1.13,7]dec-1-ylphenoxy)acetyl]aMino]-benzoic Acid Methyl Ester
  • Hypoxia inducible factor-1α inhibitor
  • LW 6 (This product is unavailable in the U.S.)
  • methyl 3-(2-(4-((1r,3r,5r,7r)-adamantan-2-yl)phenoxy)acetamido)-4-hydroxybenzoate
  • W6
  • Benzoic acid, 4-hydroxy-3-[[2-(4-tricyclo[3.3.1.13,7]dec-1-ylphenoxy)acetyl]amino]-, methyl ester
  • 3-[[[4-(Adamantan-1-yl)phenoxy]acetyl]amino]-4-hydroxybenzoic Acid Methyl Ester
  • Methyl 3-[[[4-(adamantan-1-yl)phenoxy]acetyl]amino]-4-hydroxybenzoate
  • methyl 3-(2-(4-(adamantan-1-yl)phenoxy)acetamido)-4-hydroxybenzoate
  • CAY10585，LW6
  • LW 6,Apoptosis,LW-8,Hypoxia-inducible factors,inhibit,HIF-PH,HIF/HIF Prolyl-Hydroxylase,LW6,LW-6,HIFs,Inhibitor,LW 8
  • LW6(CAY10585)
  • CAY10585, HIF-1alpha inhibitor
  • LW6, 10 mM in DMSO
  • 934593-90-5
  • Aromatics, Inhibitors