ChemicalBook > CAS DataBase List > 4-(4-CHLOROTHIAZOL-2-YL)MORPHOLINE

4-(4-CHLOROTHIAZOL-2-YL)MORPHOLINE

Product Name
4-(4-CHLOROTHIAZOL-2-YL)MORPHOLINE
CAS No.
848841-68-9
Chemical Name
4-(4-CHLOROTHIAZOL-2-YL)MORPHOLINE
Synonyms
4-(4-Chlorothiazol-2-yl);4-(4-CHLOROTHIAZOL-2-YL)MORPHOLINE;Morpholine, 4-(4-chloro-2-thiazolyl)-
CBNumber
CB92452770
Molecular Formula
C7H9ClN2OS
Formula Weight
204.68
MOL File
848841-68-9.mol
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4-(4-CHLOROTHIAZOL-2-YL)MORPHOLINE Property

Boiling point:
327.3±52.0 °C(Predicted)
Density 
1.388±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
2.31±0.50(Predicted)
Appearance
Off-white to light yellow Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C351370
Product name
4-(4-Chlorothiazol-2-yl)morpholine
Packaging
100mg
Price
$220
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC153662
Product name
4-(4-Chlorothiazol-2-yl)morpholine
Packaging
25mg
Price
$65
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC153662
Product name
4-(4-Chlorothiazol-2-yl)morpholine
Packaging
50mg
Price
$100
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC153662
Product name
4-(4-Chlorothiazol-2-yl)morpholine
Packaging
100mg
Price
$150
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC153662
Product name
4-(4-Chlorothiazol-2-yl)morpholine
Packaging
250mg
Price
$250
Updated
2021/12/16
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4-(4-CHLOROTHIAZOL-2-YL)MORPHOLINE Chemical Properties,Usage,Production

Synthesis

110-91-8

4175-76-2

848841-68-9

A reaction was carried out in acetonitrile (425 mL) with 2,4-dichlorothiazole (34 g, 0.22 mol) and morpholine (21.2 mL, 0.225 mol). Potassium carbonate (60.9 g, 0.44 mol) was first added to the reaction system, followed by slow dropwise addition of morpholine over 30 min. The reaction mixture was refluxed at 40 °C and cooled to 22 °C upon completion. The reaction solution was filtered and the filtrate was evaporated to remove the solvent. The residue was ground with isopropanol (60 mL) at 22 °C for 1 h to promote crystallization. The solid product was collected by filtration and dried under vacuum to constant weight to give the final 4-(4-chlorothiazol-2-yl)morpholine (34.5 g, 76% yield). The product was confirmed by electrospray mass spectrometry (ES/MS), m/z (35Cl) 205 (M + 1)+.

References

[1] Patent: WO2008/36579, 2008, A1. Location in patent: Page/Page column 37
[2] Patent: WO2008/83070, 2008, A1. Location in patent: Page/Page column 63
[3] Patent: WO2005/28444, 2005, A1. Location in patent: Page/Page column 73

4-(4-CHLOROTHIAZOL-2-YL)MORPHOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(4-CHLOROTHIAZOL-2-YL)MORPHOLINE Suppliers

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848841-68-9, 4-(4-CHLOROTHIAZOL-2-YL)MORPHOLINERelated Search:


  • 4-(4-CHLOROTHIAZOL-2-YL)MORPHOLINE
  • 4-(4-Chlorothiazol-2-yl)
  • Morpholine, 4-(4-chloro-2-thiazolyl)-
  • 848841-68-9