4-(4-CHLOROTHIAZOL-2-YL)MORPHOLINE
- Product Name
- 4-(4-CHLOROTHIAZOL-2-YL)MORPHOLINE
- CAS No.
- 848841-68-9
- Chemical Name
- 4-(4-CHLOROTHIAZOL-2-YL)MORPHOLINE
- Synonyms
- 4-(4-Chlorothiazol-2-yl);4-(4-CHLOROTHIAZOL-2-YL)MORPHOLINE;Morpholine, 4-(4-chloro-2-thiazolyl)-
- CBNumber
- CB92452770
- Molecular Formula
- C7H9ClN2OS
- Formula Weight
- 204.68
- MOL File
- 848841-68-9.mol
4-(4-CHLOROTHIAZOL-2-YL)MORPHOLINE Property
- Boiling point:
- 327.3±52.0 °C(Predicted)
- Density
- 1.388±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 2.31±0.50(Predicted)
- Appearance
- Off-white to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C351370
- Product name
- 4-(4-Chlorothiazol-2-yl)morpholine
- Packaging
- 100mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- FC153662
- Product name
- 4-(4-Chlorothiazol-2-yl)morpholine
- Packaging
- 25mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FC153662
- Product name
- 4-(4-Chlorothiazol-2-yl)morpholine
- Packaging
- 50mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- FC153662
- Product name
- 4-(4-Chlorothiazol-2-yl)morpholine
- Packaging
- 100mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- FC153662
- Product name
- 4-(4-Chlorothiazol-2-yl)morpholine
- Packaging
- 250mg
- Price
- $250
- Updated
- 2021/12/16
4-(4-CHLOROTHIAZOL-2-YL)MORPHOLINE Chemical Properties,Usage,Production
Synthesis
110-91-8
4175-76-2
848841-68-9
A reaction was carried out in acetonitrile (425 mL) with 2,4-dichlorothiazole (34 g, 0.22 mol) and morpholine (21.2 mL, 0.225 mol). Potassium carbonate (60.9 g, 0.44 mol) was first added to the reaction system, followed by slow dropwise addition of morpholine over 30 min. The reaction mixture was refluxed at 40 °C and cooled to 22 °C upon completion. The reaction solution was filtered and the filtrate was evaporated to remove the solvent. The residue was ground with isopropanol (60 mL) at 22 °C for 1 h to promote crystallization. The solid product was collected by filtration and dried under vacuum to constant weight to give the final 4-(4-chlorothiazol-2-yl)morpholine (34.5 g, 76% yield). The product was confirmed by electrospray mass spectrometry (ES/MS), m/z (35Cl) 205 (M + 1)+.
References
[1] Patent: WO2008/36579, 2008, A1. Location in patent: Page/Page column 37
[2] Patent: WO2008/83070, 2008, A1. Location in patent: Page/Page column 63
[3] Patent: WO2005/28444, 2005, A1. Location in patent: Page/Page column 73
4-(4-CHLOROTHIAZOL-2-YL)MORPHOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
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