ChemicalBook > CAS DataBase List > 1-BENZYL-1H-PYRAZOLE-4-CARBONITRILE

1-BENZYL-1H-PYRAZOLE-4-CARBONITRILE

Product Name
1-BENZYL-1H-PYRAZOLE-4-CARBONITRILE
CAS No.
121358-86-9
Chemical Name
1-BENZYL-1H-PYRAZOLE-4-CARBONITRILE
Synonyms
4-cyano-1-benylpyrazole;1-Benzyl-4-cyanopyrazole;4-cyano-1-benylpyrazole 1-benzylpyrazole-4-carbonitrile;1-Benzyl-1H-pyrazol-4-carbonitrile;1-BENZYL-1H-PYRAZOLE-4-CARBONITRILE;1-(Phenylmethyl)-1H-pyrazole-4-carbonitrile;1H-Pyrazole-4-carbonitrile, 1-(phenylmethyl)-
CBNumber
CB92453742
Molecular Formula
C11H9N3
Formula Weight
183.21
MOL File
121358-86-9.mol
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1-BENZYL-1H-PYRAZOLE-4-CARBONITRILE Property

Melting point:
63-64 °C(Solv: ligroine (8032-32-4))
Boiling point:
369.3±25.0 °C(Predicted)
Density 
1.11±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
-1.65±0.10(Predicted)
Appearance
Off-white to light yellow Solid
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Safety

HS Code 
2933199090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B288920
Product name
1-Benzyl-1H-pyrazole-4-carbonitrile
Packaging
100mg
Price
$60
Updated
2021/12/16
TRC
Product number
B288920
Product name
1-Benzyl-1H-pyrazole-4-carbonitrile
Packaging
500mg
Price
$155
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB140489
Product name
1-Benzyl-1H-pyrazole-4-carbonitrile
Packaging
1g
Price
$168
Updated
2021/12/16
SynQuest Laboratories
Product number
3H37-1-8H
Product name
1-Benzyl-1H-pyrazole-4-carbonitrile
Purity
95%
Packaging
250mg
Price
$240
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB140489
Product name
1-Benzyl-1H-pyrazole-4-carbonitrile
Packaging
2g
Price
$293
Updated
2021/12/16
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1-BENZYL-1H-PYRAZOLE-4-CARBONITRILE Chemical Properties,Usage,Production

Synthesis

63874-95-3

121358-86-9

General procedure for the synthesis of 1-benzyl-4-cyanopyrazole from 1-phenyl-1H-pyrazole-4-carboxaldehyde: 1-benzyl-1H-pyrazole-4-carboxaldehyde (18.6 g, 0.1 mol), sodium bromate (7.5 g, 0.05 mol), and 200 g of acetic acid were mixed at room temperature, followed by the slow addition of 50 g of 25% aqueous ammonia solution. To the reaction mixture was added 300 mL of water, heated to 90 °C, exothermic during the reaction, the reaction temperature was maintained at 100 °C, and the reaction was refluxed for 1 h until 1-benzyl-1H-pyrazole-4-carbaldehyde was fully reacted. After completion of the reaction, it was cooled to room temperature and the reaction solution was poured into ice water for quenching and dilution. Subsequently, the reaction solution was neutralized with a suitable base, the organic phase was extracted with dichloromethane, dried over anhydrous sodium sulfate and concentrated under reduced pressure. Finally, the target product 1-benzyl-4-cyanopyrazole 16.6 g was obtained in 91% yield and ≥98% purity by decompression distillation and recrystallization purification.

References

[1] Patent: CN108707113, 2018, A. Location in patent: Paragraph 0032
[2] Heterocycles, 1988, vol. 27, # 10, p. 2443 - 2458
[3] Heterocycles, 1988, vol. 27, # 10, p. 2443 - 2458

1-BENZYL-1H-PYRAZOLE-4-CARBONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-BENZYL-1H-PYRAZOLE-4-CARBONITRILE Suppliers

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View Lastest Price from 1-BENZYL-1H-PYRAZOLE-4-CARBONITRILE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
1-BENZYL-1H-PYRAZOLE-4-CARBONITRILE 121358-86-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
1-BENZYL-1H-PYRAZOLE-4-CARBONITRILE 121358-86-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

121358-86-9, 1-BENZYL-1H-PYRAZOLE-4-CARBONITRILERelated Search:

Zaleplon 7-(2,4-DICHLOROPHENYL)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBONITRILE 7-(4-PHENOXYPHENYL)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBONITRILE 5-AMINO-1- BENZYL-1H-PYRAZOLE-4-CARBONITRILE 7-PHENYLPYRAZOLO[1,5-A]PYRIMIDINE-3-CARBONITRILE 1-BENZYL-1H-PYRAZOLE 7-(2-[(4-CHLOROBENZYL)OXY]PHENYL)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBONITRILE 7-(4-METHOXYPHENYL)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBONITRILE 7-[4-(1H-1,2,4-TRIAZOL-1-YL)PHENYL]PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBONITRILE 2-(CYANOMETHYL)-7-PHENYLPYRAZOLO[1,5-A]PYRIMIDINE-3-CARBONITRILE 6,7-BIS(4-METHOXYPHENYL)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBONITRILE 7-[4-(1H-1,3-BENZIMIDAZOL-1-YL)PHENYL]PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBONITRILE 7-(1,3-BENZODIOXOL-5-YL)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBONITRILE 7-(3,4-DICHLOROPHENYL)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBONITRILE 7-[4-(2,5-DIMETHYL-1H-PYRROL-1-YL)PHENYL]PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBONITRILE 7-(4-BROMOPHENYL)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBONITRILE 7-(3-[(2,4-DICHLOROBENZYL)OXY]PHENYL)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBONITRILE 7-(4-FLUOROPHENYL)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBONITRILE

  • 1-BENZYL-1H-PYRAZOLE-4-CARBONITRILE
  • 1-Benzyl-4-cyanopyrazole
  • 4-cyano-1-benylpyrazole
  • 1-benzylpyrazole-4-carbonitrile
  • 4-cyano-1-benylpyrazole&nbsp
  • 1-Benzyl-1H-pyrazol-4-carbonitrile
  • 1H-Pyrazole-4-carbonitrile, 1-(phenylmethyl)-
  • 1-(Phenylmethyl)-1H-pyrazole-4-carbonitrile
  • 121358-86-9