ChemicalBook > CAS DataBase List > BX-912

BX-912

Product Name
BX-912
CAS No.
702674-56-4
Chemical Name
BX-912
Synonyms
BX 912;CS-339;BX912/BX-912;BX-912, >=98%;Apoptosis,PDK-1,inhibit,BX912,BX-912,Inhibitor,BX 912;N-(3-((4-((2-(1H-Imidazol-4-yl)ethyl)amino)-5-bromopyrimidin-2-yl)amino)phenyl)pyrrolidine-1-c;N-(3-(4-(2-(1H-imidazol-5-yl)ethylamino)-5-bromopyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide;N-[3-[[4-[[2-(4-Imidazolyl)ethyl]amino]-5-bromo-2-pyrimidinyl]amino]phenyl]pyrrolidine-1-carboxamide;N-[3-[[5-Bromo-4-[[2-(1H-imidazol-5-yl)ethyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide;N-(3-((4-((2-(1H-imidazol-4-yl)ethyl)amino)-5-bromopyrimidin-2-yl)amino)phenyl)pyrrolidine-1-carboxamide
CBNumber
CB92454082
Molecular Formula
C20H23BrN8O
Formula Weight
471.35
MOL File
702674-56-4.mol
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BX-912 Property

Density 
1.596
storage temp. 
-20°C
solubility 
≥23.55 mg/mL in DMSO; insoluble in H2O; ≥10.25 mg/mL in EtOH
form 
powder
color 
white to beige
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1086
Product name
BX-912
Purity
≥95% (HPLC)
Packaging
5mg
Price
$106
Updated
2024/03/01
Sigma-Aldrich
Product number
SML1086
Product name
BX-912
Purity
≥95% (HPLC)
Packaging
25mg
Price
$417
Updated
2024/03/01
Cayman Chemical
Product number
14708
Product name
BX-912
Purity
≥98%
Packaging
1mg
Price
$45
Updated
2024/03/01
Cayman Chemical
Product number
14708
Product name
BX-912
Purity
≥98%
Packaging
5mg
Price
$100
Updated
2024/03/01
Cayman Chemical
Product number
14708
Product name
BX-912
Purity
≥98%
Packaging
10mg
Price
$177
Updated
2024/03/01
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BX-912 Chemical Properties,Usage,Production

Description

3-Phosphoinositide-dependent protein kinase 1 (PDK1) is a serine-threonine kinase that phosphorylates and activates a range of other kinases, including protein kinase (PK)B, PKA, and certain isoforms of PKC. BX-912 is a potent, ATP-competitive inhibitor of PDK1 (IC50 = 26 nM). It less effectively inhibits a panel of related serine-threonine kinases. BX-912 has been used to evaluate the role of PDK1 in kinase activation and cell survival.

Uses

A selective potent PDK-1 inhibitor with an IC50 of 12 nM.

Uses

BX-912 is a selective potent 3-Phosphoinositide-dependent Kinase-1 (PDK1) inhibitor. BX-192 shows potential anticancer properties as it inibits PDK1 activity towards the signaling pathway in cancer cell growth, survival and tumor angiogenesis.

Definition

ChEBI: N-[3-[[5-bromo-4-[2-(1H-imidazol-5-yl)ethylamino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide is a member of ureas.

target

PDK-1

References

[1] feldman ri1, wu jm, polokoff ma, kochanny mj, dinter h, zhu d, biroc sl, alicke b, bryant j, yuan s, buckman bo, lentz d, ferrer m, whitlow m, adler m, finster s, chang z, arnaiz do. novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1. j biol chem. 2005 may 20;280(20):19867-74. epub 2005 mar 16.

BX-912 Preparation Products And Raw materials

Raw materials

Preparation Products

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BX-912 Suppliers

Austria 1 China 103 Germany 1 India 1 The Netherlands 1 Ukraine 1 United Kingdom 1 United States 19 Global 128
Axon Medchem BV
Tel
--
Fax
--
Email
info@axonmedchem.com
Country
The Netherlands
ProdList
477
Advantage
30
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View Lastest Price from BX-912 manufacturers

Career Henan Chemical Co
Product
BX-912 702674-56-4
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-24

702674-56-4, BX-912Related Search:

MK-1775 Selumetinib ABT 737 Trametinib Rapamycin Olaparib BX-912 (5-BROMO-PYRIMIDIN-2-YL)-PHENYL-AMINE

  • 1-PYRROLIDINECARBOXAMIDE, N-[3-[[5-BROMO-4-[[2-(1H-IMIDAZOL-4-YL)ETHYL]AMINO]-2-PYRIMIDINYL]AMINO]PHENYL]-
  • BX 912
  • PYRROLIDINE-1-CARBOXYLIC ACID (3-(5-BROMO-4-[2-(1H-IMIDAZOL-4-YL)-ETHYLAMINO]-PYRIMIDIN-2-YLAMINO)-PHENYL)-AMIDE
  • N-[3-[[5-Bromo-4-[[2-(1H-imidazol-5-yl)ethyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide
  • BX912/BX-912
  • N-[3-[[5-Bromo-4-[[2-(1H-imidazol-5-yl)ethyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide BX912/BX-912 N-(3-(4-(2-(1H-imidazol-5-yl)ethylamino)-5-bromopyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide BX-912 N-[3-[[5-Bromo-4-[[2-(1H-imid
  • N-(3-((4-((2-(1H-Imidazol-4-yl)ethyl)amino)-5-bromopyrimidin-2-yl)amino)phenyl)pyrrolidine-1-c
  • N-(3-(4-(2-(1H-imidazol-5-yl)ethylamino)-5-bromopyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide
  • BX-912 N-[3-[[5-Bromo-4-[[2-(1H-imidazol-5-yl)ethyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide
  • N-[3-[[5-Bromo-4-[[2-(1H-imidazol-5-yl)ethyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide BX-912
  • BX9121-PYRROLIDINECARBOXAMIDE,N-[3-[[5-BROMO-4-[[2-(1H-IMIDAZOL-4-YL)ETHYL]AMINO]-2-PYRIMIDINYL]AMINO]PHENYL]-
  • BX-912, >=98%
  • CS-339
  • 1-Pyrrolidinecarboxamide, N-[3-[[5-bromo-4-[[2-(1H-imidazol-5-yl)ethyl]amino]-2-pyrimidinyl]amino]phenyl]-
  • N-(3-((4-((2-(1H-imidazol-4-yl)ethyl)amino)-5-bromopyrimidin-2-yl)amino)phenyl)pyrrolidine-1-carboxamide
  • N-[3-[[4-[[2-(4-Imidazolyl)ethyl]amino]-5-bromo-2-pyrimidinyl]amino]phenyl]pyrrolidine-1-carboxamide
  • Apoptosis,PDK-1,inhibit,BX912,BX-912,Inhibitor,BX 912
  • 702674-56-4
  • C20H23BrN8O
  • Inhibitors
  • Inhibitor of 3-Phosphoinositide-dependent Kinase-1 (PDK1).
  • Akt
  • mTOR
  • PI3K