2-AMINO-5-(TRIFLUOROMETHYL)PYRAZINE

Product Name: 2-AMINO-5-(TRIFLUOROMETHYL)PYRAZINE
CAS No.: 69816-38-2
Chemical Name: 2-AMINO-5-(TRIFLUOROMETHYL)PYRAZINE
Synonyms: 3-Oxetanol,4-ethynyl-;5-(trifluoromethyl)-2-Pyrazinamine;5-(TRIFLUOROMETHYL)PYRAZIN-2-AMINE;2-AMINO-5-(TRIFLUOROMETHYL)PYRAZINE;5-(Trifluoromethyl)pyrazine-2-amine;5-TrifluoroMethyl-pyrazin-2-ylaMine;2-Pyrazinamine, 5-(trifluoromethyl)-
CBNumber: CB92454587
Molecular Formula: C5H4F3N3
Formula Weight: 163.1
MOL File: 69816-38-2.mol

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2-AMINO-5-(TRIFLUOROMETHYL)PYRAZINE Property

Boiling point:: 226.2±40.0 °C(Predicted)
Density: 1.460±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 1.50±0.10(Predicted)
Appearance: White to light yellow Solid
InChI: InChI=1S/C5H4F3N3/c6-5(7,8)3-1-11-4(9)2-10-3/h1-2H,(H2,9,11)
InChIKey: ILDRNIDSVAZBMZ-UHFFFAOYSA-N
SMILES: C1(N)=NC=C(C(F)(F)F)N=C1

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC

Product number: T898875
Product name: 5-(trifluoromethyl)pyrazin-2-amine
Packaging: 10mg
Price: $45
Updated: 2021/12/16

TRC

Product number: T898875
Product name: 5-(trifluoromethyl)pyrazin-2-amine
Packaging: 100mg
Price: $130
Updated: 2021/12/16

AK Scientific

Product number: Y9859
Product name: 5-(Trifluoromethyl)pyrazin-2-amine
Packaging: 1g
Price: $318
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H30-3-6S
Product name: 5-(Trifluoromethyl)pyrazin-2-amine
Purity: 95.0%
Packaging: 1g
Price: $484
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0367557
Product name: 5-(TRIFLUOROMETHYL)PYRAZIN-2-AMINE
Purity: 95.00%
Packaging: 5MG
Price: $501.77
Updated: 2021/12/16

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2-AMINO-5-(TRIFLUOROMETHYL)PYRAZINE Chemical Properties,Usage,Production

Synthesis

799557-87-2

69816-38-2

General procedure for the synthesis of 2-amino-5-trifluoromethylpyrazine from 2-chloro-5-trifluoromethylpyrazine: 2-chloro-5-(trifluoromethyl)pyrazine (5.0 g, 27 mmol) was mixed with ammonium hydroxide (190 mL, 2.7 mol) and the reaction was stirred for 3.5 h at 80 °C in a sealed pressure vessel. After completion of the reaction, it was cooled to room temperature and the reaction mixture was extracted with dichloromethane (4×). The organic phases were combined, dried over anhydrous sodium sulfate, filtered and concentrated to give 2-amino-5-trifluoromethylpyrazine (4.0 g, 90% yield) as a white solid. The product was confirmed by 1H NMR (400 MHz, CDCl3): δ 8.34 (s, 1H), 8.01 (s, 1H), 5.01 (br s, 2H).The LCMS analysis showed that the calculated value of [M+H]+ m/z was 164.0, and the measured value was 164.1, which was in agreement with the target compound.

References

[1] Patent: US2018/9816, 2018, A1. Location in patent: Paragraph 1377; 1378

2-AMINO-5-(TRIFLUOROMETHYL)PYRAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-AMINO-5-(TRIFLUOROMETHYL)PYRAZINE Suppliers

China 76 India 1 United States 13 Global 90

Shanghai Chenghe Medical Technology Co. Ltd.

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View Lastest Price from 2-AMINO-5-(TRIFLUOROMETHYL)PYRAZINE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 5-(trifluoromethyl)pyrazin-2-amine 69816-38-2
Price: US $1.60-9.60/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-20

Henan Aochuang Chemical Co.,Ltd.

Product: 2-AMINO-5-(TRIFLUOROMETHYL)PYRAZINE 69816-38-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-29

Career Henan Chemical Co

Product: 2-AMINO-5-(TRIFLUOROMETHYL)PYRAZINE 69816-38-2
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-07-12

69816-38-2, 2-AMINO-5-(TRIFLUOROMETHYL)PYRAZINERelated Search:

2-AMINO-5-(TRIFLUOROMETHYL)PYRAZINE

5-TrifluoroMethyl-pyrazin-2-ylaMine

5-(Trifluoromethyl)pyrazine-2-amine

5-(trifluoromethyl)-2-Pyrazinamine

2-AMINO-5-(TRIFLUOROMETHYL)PYRAZINE

5-(TRIFLUOROMETHYL)PYRAZIN-2-AMINE

2-Pyrazinamine, 5-(trifluoromethyl)-

3-Oxetanol,4-ethynyl-

69816-38-2