5-BENZOXAZOLOL, 2-METHYL-
- Product Name
- 5-BENZOXAZOLOL, 2-METHYL-
- CAS No.
- 23997-94-6
- Chemical Name
- 5-BENZOXAZOLOL, 2-METHYL-
- Synonyms
- 5-BENZOXAZOLOL, 2-METHYL-;2-methylbenzo[d]oxazol-5-ol;2-methyl-1,3-benzoxazol-5-ol;5-Hydroxy-2-methylbenzoxazole;5-hydroxy-2-methylbenzo[d]oxazole;5-BENZOXAZOLOL, 2-METHYL- ISO 9001：2015 REACH
- CBNumber
- CB92456248
- Molecular Formula
- C8H7NO2
- Formula Weight
- 149.15
- MOL File
- 23997-94-6.mol
5-BENZOXAZOLOL, 2-METHYL- Property
- Melting point:
- 164-165 °C
- Boiling point:
- 278.7±13.0 °C(Predicted)
- Density
- 1.305±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- form
- solid
- pka
- 8.70±0.10(Predicted)
- Appearance
- Light yellow to yellow Solid
- InChI
- 1S/C8H7NO2/c1-5-9-7-4-6(10)2-3-8(7)11-5/h2-4,10H,1H3
- InChIKey
- VWFUDKCJVNWDPI-UHFFFAOYSA-N
- SMILES
- Cc1nc2cc(O)ccc2o1
N-Bromosuccinimide Price
- Product number
- M282995
- Product name
- 2-Methylbenzo[d]oxazol-5-ol
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- CS-W021726
- Product name
- 2-Methylbenzo[d]oxazol-5-ol
- Purity
- >98.0%
- Packaging
- 1g
- Price
- $114
- Updated
- 2021/12/16
- Product number
- X5142
- Product name
- 2-Methylbenzo[d]oxazol-5-ol
- Packaging
- 250mg
- Price
- $117
- Updated
- 2021/12/16
- Product number
- OR948086
- Product name
- 2-Methylbenzo[d]oxazol-5-ol
- Purity
- 95%
- Packaging
- 250mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- OR948086
- Product name
- 2-Methylbenzo[d]oxazol-5-ol
- Purity
- 95%
- Packaging
- 1g
- Price
- $275
- Updated
- 2021/12/16
5-BENZOXAZOLOL, 2-METHYL- Chemical Properties,Usage,Production
Application
2-Methylbenzo[d]oxazol-5-ol is a useful research chemical.
Synthesis
24558-42-7
23997-94-6
The general procedure for the synthesis of 5-hydroxy-2-methylbenzoxazole from the compound (CAS: 24558-42-7) was as follows: compound 2 (20.0 g, 119.7 mmol) was dissolved in N,N-dimethylformamide (DMF, 300 mL) and the solution was cooled to 0 °C. Phosphorus oxychloride (POCl3, 20 g, 131.6 mmol) was slowly added dropwise while keeping the internal temperature below 10 °C. After the dropwise addition, the reaction mixture was continued to be stirred at 0°C for 1 hour. After completion of the reaction, water (1 L) was added to the reaction mixture and extracted with ethyl acetate (EA, 300 mL x 3). The organic phases were combined and concentrated. The concentrated residue was dissolved in methyl tert-butyl ether (MTBE, 800 mL) and washed with deionized water (200 mL × 3). The organic layer was dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated. Finally, the residue was washed with a solvent mixture of dichloromethane (DCM) and petroleum ether (PE) (4:1, 250 mL, v/v) to afford compound 3 (13.5 g, 75.6% yield).
References
[1] Patent: JP2015/214548, 2015, A. Location in patent: Paragraph 1369; 1371; 1372
[2] Patent: EP2090575, 2009, A1. Location in patent: Page/Page column 50
5-BENZOXAZOLOL, 2-METHYL- Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-BENZOXAZOLOL, 2-METHYL- manufacturers
- Product
- 5-BENZOXAZOLOL, 2-METHYL- 23997-94-6
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-14