ChemicalBook > CAS DataBase List > TETRABENAZINE

TETRABENAZINE

Product Name: TETRABENAZINE
CAS No.: 718635-93-9
Chemical Name: TETRABENAZINE
Synonyms: Dolalgial;TETRABENAZINE（b）;rac-Tetrabenazine;Ro 1-9569 Racemate;Cis Trans Tetrabenazine;Tetrabenazine (Racemate);Tetrabenazine Impurity 10;Tetrabenazine Impurity 46;Tetrabenazine Racemate, >98%;TETRABENAZINE RACEMATE;RO 1-9569 RACEMATE
CBNumber: CB92457043
Molecular Formula: C19H27NO3
Formula Weight: 317.42
MOL File: 718635-93-9.mol

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TETRABENAZINE Property

Melting point:: 125 °C
Boiling point:: 448.9±45.0 °C(Predicted)
Density: 1.12±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: ≥ 3.2 mg/mL (10.08 mM)
form: Solid
pka: 6.46±0.40(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: T889552
Product name: Tetrabenazine
Packaging: 5mg
Price: $75
Updated: 2021/12/16

ChemScene

Product number: CS-5700
Product name: Tetrabenazine(Racemate)
Purity: >98.0%
Packaging: 25mg
Price: $100
Updated: 2021/12/16

ChemScene

Product number: CS-5700
Product name: Tetrabenazine(Racemate)
Purity: >98.0%
Packaging: 50mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-5700
Product name: Tetrabenazine(Racemate)
Purity: >98.0%
Packaging: 100mg
Price: $200
Updated: 2021/12/16

Crysdot

Product number: CD11067653
Product name: TetrabenazineRacemate
Purity: 95+%
Packaging: 100mg
Price: $247
Updated: 2021/12/16

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TETRABENAZINE Chemical Properties,Usage,Production

Uses

Tetrabenazine is a dopamine depleting medication for the treatment of chorea in Huntington’s disease.

Definition

ChEBI: 9,10-dimethoxy-3-isobutyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one is a benzoquinolizine that is 1,2,3,4,4a,9,10,10a-octahydrophenanthrene in which the carbon at position 10a is replaced by a nitrogen and which is substituted by an isobutyl group at position 2, an oxo group at position 3, and methoxy groups at positions 6 and 7. It is a benzoquinolizine, a cyclic ketone and a tertiary amino compound.

Synthesis

91342-74-4

20232-39-7

718635-93-9

6,7-Dimethoxy-3,4-dihydroisoquinoline hydrochloride (118.2 kg) was dissolved in water (3 volumes). A solution of 3-((dimethylamino)methyl)-5-methylhexan-2-one (99.1 kg) in n-heptane (1.5 vol) was added, and the reaction mixture was stirred vigorously at 35 °C for at least 48 hours until the amount of 6,7-dimethoxy-3,4-dihydroisoquinoline was reduced to less than 10% of the initial amount (as detected by a standard solution). After completion of the reaction, the solid product was collected by filtration, washed sequentially with water and n-heptane, and then dried under vacuum to afford 3-isobutyl-9,10-dimethoxy-3,4,6,7-tetrahydro-1H-pyrido[2,1-a]isoquinolin-2(11bH)-one (141.1 kg, 85.6% yield).

References

[1] Patent: US2017/183346, 2017, A1. Location in patent: Paragraph 0165
[2] Patent: US2017/183346, 2017, A1. Location in patent: Paragraph 0162; 0164
[3] Patent: CN107698582, 2018, A. Location in patent: Paragraph 0019
[4] Journal of Labelled Compounds and Radiopharmaceuticals, 2011, vol. 54, # 7, p. 367 - 370

TETRABENAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

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718635-93-9, TETRABENAZINERelated Search:

Tetrabenazine Racemate, >98%

Ro 1-9569 Racemate

TETRABENAZINE RACEMATE;RO 1-9569 RACEMATE

2H-Benzo[a]quinolizin-2-one, 1,3,4,6,7,11b-hexahydro-9,10-diMethoxy-3-(2-Methylpropyl)-

3-Isobutyl-9,10-dimethoxy-3,4,6,7-tetrahydro-1H-pyrido[2,1-a]isoquinolin-2(11bH)-one

Tetrabenazine (Racemate)

Tetrabenazine Impurity 10

3-isobutyl-9,10-dimethoxy-3,4,6,7-tetrahydro-1H-pyrido[2,

Cis Trans Tetrabenazine

Tetrabenazine Racemates (Mixture of Cis - Trance Tetrabenazine)

Dolalgial

TETRABENAZINE（b）

3-(dimethylamino)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one

rac-Tetrabenazine

Tetrabenazine Impurity 46

718635-93-9