4,7-DICHLORO-THIENO[2,3-D]PYRIDAZINE
Uses- Product Name
- 4,7-DICHLORO-THIENO[2,3-D]PYRIDAZINE
- CAS No.
- 699-89-8
- Chemical Name
- 4,7-DICHLORO-THIENO[2,3-D]PYRIDAZINE
- Synonyms
- 4,7-DICHLORO-THIENO[2,3-D]PYRIDAZINE;Thieno[2,3-d]pyridazine, 4,7-dichloro-;4,7-Dichlorothieno[2,3-d]pyridazine 25 g/50
- CBNumber
- CB92460148
- Molecular Formula
- C6H2Cl2N2S
- Formula Weight
- 205.06
- MOL File
- 699-89-8.mol
4,7-DICHLORO-THIENO[2,3-D]PYRIDAZINE Property
- Melting point:
- 157-158 °C
- Boiling point:
- 409.6±40.0 °C(Predicted)
- Density
- 1.662±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- -2?+-.0.40(Predicted)
- Appearance
- Light brown to yellow Solid
Safety
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P363Wash contaminated clothing before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
N-Bromosuccinimide Price
- Product number
- D437575
- Product name
- 4,7-Dichlorothieno[2,3-D]pyridazine
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FD135167
- Product name
- 4,7-Dichlorothieno[2,3-d]pyridazine
- Packaging
- 100mg
- Price
- $72
- Updated
- 2021/12/16
- Product number
- FD135167
- Product name
- 4,7-Dichlorothieno[2,3-d]pyridazine
- Packaging
- 250mg
- Price
- $145
- Updated
- 2021/12/16
- Product number
- FD135167
- Product name
- 4,7-Dichlorothieno[2,3-d]pyridazine
- Packaging
- 500mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- W7967
- Product name
- 4,7-Dichlorothieno[2,3-d]pyridazine
- Packaging
- 1g
- Price
- $284
- Updated
- 2021/12/16
4,7-DICHLORO-THIENO[2,3-D]PYRIDAZINE Chemical Properties,Usage,Production
Uses
4,7-Dichlorothiopheno[2,3-D]pyridazine can be used as a pharmaceutical synthesis intermediate. It can be prepared by using 3-thiophenecarboxylic acid as a reaction raw material to prepare the intermediate thiophene-2,3-dicarboxylic acid, which is then further esterified with methanol, and then reacted with hydrazine hydrate and phosphorus oxychloride to obtain the final product.
Synthesis
91533-21-0
699-89-8
The general procedure for the synthesis of 4,7-dichlorothieno[2,3-d]pyrazine from 5,6-dihydrothieno[2,3-D]pyridazine-4,7-dione was carried out as follows: a 250 mL round-bottomed flask was equipped with a stirrer and reflux condenser tube. To the flask was added 5,6-dihydrothieno[2,3-D]pyridazine-4,7-dione (2.5 g, 14.8 mmol), phosphorus trichloride (45 mL, 481 mmol), and pyridine (4.57 mL, 55 mmol), and heated and refluxed for 2.5 hours. After the reaction was completed, it was cooled to room temperature and the reaction solution was slowly poured into ice water. The mixture was separated and the aqueous phase was extracted with chloroform (4 x 75 mL). The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford the dark yellow solid product 4,7-dichlorothieno[2,3-d]pyrazine (Intermediate B; 1.5 g, 7.3 mmol; 49% yield). The product was characterized by the following data: melting point 260-263 °C; 1H NMR (DMSO-d6) δ 8.55 (d, J = 5.7 Hz, 1H), 7.80 (d, J = 5.7 Hz, 1H); ESI-MS (M + H)+ m/z = 206; TLC (hexane-ethyl acetate, 70:30) Rf = 0.56. For related literature see: Robba, M.; Bull. Soc. Chim. Fr.; 1967, 4220-4235.
References
[1] Patent: WO2007/118602, 2007, A1. Location in patent: Page/Page column 57
[2] Patent: US6689883, 2004, B1. Location in patent: Page column 50
[3] Bulletin de la Societe Chimique de France, 1967, p. 4220 - 4235
[4] Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1964, vol. 259, p. 4726 - 4728
4,7-DICHLORO-THIENO[2,3-D]PYRIDAZINE Preparation Products And Raw materials
Raw materials
Preparation Products
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