7-Methoxy-1-naphthaleneacetic acid ethyl ester
- Product Name
- 7-Methoxy-1-naphthaleneacetic acid ethyl ester
- CAS No.
- 6836-21-1
- Chemical Name
- 7-Methoxy-1-naphthaleneacetic acid ethyl ester
- Synonyms
- Ethyl 2-(7-methoxynaphthalen-1-yl);Ethyl (7-methoxy-1-naphthyl)acetate;Ethyl 7-Methoxynaphthalene-1-acetate;Ethyl (7-Methoxynaphthalen-1-yl)acetate;Ethyl 2-(7-Methoxynaphthalen-1-yl)acetate;7-Methoxy-1-phthaleneacetic acid ethyl ester;7-Methoxy-1-naphthaleneacetic acid ethyl ester;1-Naphthaleneacetic acid, 7-methoxy-, ethyl ester
- CBNumber
- CB92462142
- Molecular Formula
- C15H16O3
- Formula Weight
- 244.29
- MOL File
- 6836-21-1.mol
7-Methoxy-1-naphthaleneacetic acid ethyl ester Property
- Boiling point:
- 136-139 °C(Press: 0.4 Torr)
- Density
- 1.126
- storage temp.
- Sealed in dry,Room Temperature
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P391Collect spillage. Hazardous to the aquatic environment
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- J52193
- Product name
- Ethyl(7-methoxy-1-naphthyl)acetate
- Packaging
- 1g
- Price
- $23
- Updated
- 2021/12/16
- Product number
- B668
- Product name
- Ethyl(7-methoxy-1-naphthyl)acetate
- Packaging
- 1g
- Price
- $31
- Updated
- 2021/12/16
- Product number
- CHM0392296
- Product name
- ETHYL-2-(7-METHOXYNAPHTHALEN-1-YL)ACETATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.02
- Updated
- 2021/12/16
- Product number
- CM140853
- Product name
- ethyl2-(7-methoxynaphthalen-1-yl)acetate
- Purity
- 97%
- Packaging
- 25g
- Price
- $234
- Updated
- 2021/12/16
- Product number
- CD12043099
- Product name
- Ethyl2-(7-methoxynaphthalen-1-yl)acetate
- Purity
- 97%
- Packaging
- 25g
- Price
- $248
- Updated
- 2021/12/16
7-Methoxy-1-naphthaleneacetic acid ethyl ester Chemical Properties,Usage,Production
Synthesis
27533-70-6
6836-21-1
General procedure for the synthesis of ethyl 7-methoxy-1-naphthylacetate from agomelatine impurity 21: To a solution of anhydrous dichloromethane (45 mL, 15 v/v) containing ethyl acetate-2-(2-methoxynaphthalen-8-yl)acetate (3 g, 12.1 mmol) was slowly added 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ. 4.15 g, 18.2 mmol). After the addition was completed, the reaction mixture was stirred continuously at 25-30 °C for 12 hours. Upon completion of the reaction, the mixture was separated by filtration and the precipitated solid was washed with dichloromethane (30 mL, 10 v/v). The organic phases were combined and washed sequentially with saturated sodium bicarbonate solution (15 mL, 3 x 5 volume), water (15 mL, 3 x 5 volume) and brine (15 mL, 3 x 5 volume). The organic layer was dried over anhydrous sodium sulfate and subsequently concentrated under reduced pressure to remove the solvent to give a brown crude product. The crude product was purified by chromatography on a 100-200 mesh silica gel column with hexane solution of 20% ethyl acetate as eluent to give a final colorless oily product (2.59 g, 87.3% yield). The product was purified by IR (KBr, νmax, cm-1): 2981,2937,2834,1733,1627,1601,1511,1469,1450,1260,1213,1159,133,832; 1H NMR (400 MHz, CDCl3): δ 7.75 (d, J=8.4 Hz, 1H). 7.71 (d, J=8.0 Hz, 1H), 7.38 (d, J=7.2 Hz, 1H), 7.30 (t, J=8.0 Hz, 2H), 7.16 (dd, J1=2.4 Hz, J2=8.8 Hz, 1H), 4.15 (q, J=7.2 Hz, 2H), 4.0 (s, 2H), 3.93 (s, 3H), 1.2 (t, J=7.2 Hz, 3H); 13C NMR (100 Hz, DMSO-d6): δ171.1,157.46,132.99,130.01,129.79,128.74,128.37,127.25,123.02,117.88,117.88,102.76,60.23, 54.94,14.0; EI-MS, m/z (%): 245 (M+1,100), 171 (17) for characterization confirmation.
References
[1] Organic Preparations and Procedures International, 2009, vol. 41, # 2, p. 164 - 168
[2] Asian Journal of Chemistry, 2016, vol. 28, # 6, p. 1367 - 1370
[3] Patent: CN104276979, 2018, B. Location in patent: Paragraph 0028; 0030; 0031
7-Methoxy-1-naphthaleneacetic acid ethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 7-Methoxy-1-naphthaleneacetic acid ethyl ester manufacturers
- Product
- 7-Methoxy-1-naphthaleneacetic acid ethyl ester 6836-21-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500kg
- Release date
- 2019-12-31