5-BROMO INDOLE-7-CARBOXYLIC ACID

Product Name: 5-BROMO INDOLE-7-CARBOXYLIC ACID
CAS No.: 860624-90-4
Chemical Name: 5-BROMO INDOLE-7-CARBOXYLIC ACID
Synonyms: 5-BROMO INDOLE-7-CARBOXYLIC ACID;5-broMo-1H-indole-7-carboxylic acid;1H-Indole-7-carboxylic acid, 5-bromo-
CBNumber: CB92465002
Molecular Formula: C9H6BrNO2
Formula Weight: 240.05
MOL File: 860624-90-4.mol

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5-BROMO INDOLE-7-CARBOXYLIC ACID Property

Boiling point:: 464.9±30.0 °C(Predicted)
Density: 1.838±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 4.15±0.10(Predicted)
Appearance: White to off-white Solid

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FB143668
Product name: 5-Bromo-1H-indole-7-carboxylic acid
Packaging: 500mg
Price: $155
Updated: 2021/12/16

Apolloscientific

Product number: OR930421
Product name: 5-Bromo-1H-indole-7-carboxylicacid
Purity: 97%
Packaging: 1g
Price: $159
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB143668
Product name: 5-Bromo-1H-indole-7-carboxylic acid
Packaging: 1g
Price: $270
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB143668
Product name: 5-Bromo-1H-indole-7-carboxylic acid
Packaging: 2g
Price: $469
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0105064
Product name: 5-BROMO INDOLE-7-CARBOXYLIC ACID
Purity: 95.00%
Packaging: 5MG
Price: $502.98
Updated: 2021/12/16

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5-BROMO INDOLE-7-CARBOXYLIC ACID Chemical Properties,Usage,Production

Synthesis

860624-89-1

860624-90-4

The general procedure for the synthesis of 5-bromo-1H-indole-7-carboxylic acid from methyl 5-bromoindole-7-carboxylate was as follows: methyl 5-bromo-1H-indole-7-carboxylate (5 g, 19.7 mmol) was dissolved in methanol (200 mL), followed by the addition of an aqueous solution (10 mL) of lithium hydroxide (0.99 g, 41 mmol). The reaction mixture was heated to reflux and kept for 50 hours. Upon completion of the reaction, methanol was removed by distillation under reduced pressure. The residue was acidified by adding 2M aqueous hydrochloric acid solution to the residue, followed by filtration to collect the precipitate precipitated. The resulting solid was dried in a heated vacuum drying oven to give 4.7 g (99% yield) of the target product 5-bromo-1H-indole-7-carboxylic acid as a beige solid. The product was characterized by 1H NMR (400 MHz, DMSO-D6): δ 6.54 (dd, J = 2.0, 3.2 Hz, 1H), 7.42 (t, J = 2.8 Hz, 1H), 7.77 (d, J = 2.0 Hz, 1H), 8.03 (d, J = 1.8 Hz, 1H), 11.27 (s, 1H), 13.1-13.7 (bs, 1H). Mass spectrometry analysis showed m/z of 238/240 (ratio 1:1, [M-1]-) and retention time (Rt) of 3.41 min.

References

[1] Patent: WO2007/62318, 2007, A2. Location in patent: Page/Page column 39
[2] Patent: WO2008/118724, 2008, A1. Location in patent: Page/Page column 70
[3] Patent: US2006/30613, 2006, A1. Location in patent: Page/Page column 22
[4] Patent: WO2006/34317, 2006, A2. Location in patent: Page/Page column 73-74
[5] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 8, p. 2255 - 2258

5-BROMO INDOLE-7-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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5-BROMO INDOLE-7-CARBOXYLIC ACID Suppliers

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860624-90-4, 5-BROMO INDOLE-7-CARBOXYLIC ACIDRelated Search:

5-BROMO INDOLE-7-CARBOXYLIC ACID

5-broMo-1H-indole-7-carboxylic acid

1H-Indole-7-carboxylic acid, 5-bromo-

860624-90-4